Editorial: Multiple Herbicide-Resistant Weeds and Non-target Site Resistance Mechanisms: A Global Challenge for Food Production

Torra, Joel; Osuna, María Dolores; Merotto, Aldo; Vila‐Aiub, Martin M.

doi:10.3389/fpls.2021.763212

Cited by 28 publications

(28 citation statements)

References 52 publications

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“…The non-target site resistance mechanism based on enhanced metabolism is a dramatic scenario in terms of weed control. There is a possibility that this metabolism may be involved in resistance to different MoAs, even if the weed has never been exposed to those herbicides (Gaines et al, 2020;Torra et al, 2021a). In our studies, several herbicides with different MOAs, 2,4-D and MCPA (auxin mimics), glyphosate (EPSPS inhibitor), metribuzin (PS II inhibitor Serine 264 binder)) and mesotrione (HPPD inhibitors) could control these Rs populations.…”

Section: Alternative Chemical Controlmentioning

confidence: 74%

“…On the other hand, NTSR mechanisms can reduce (decreased foliar uptake, translocation, vacuolar sequestration or enhanced metabolism) the toxic form of the herbicide before reaching the target site. (Yu and Powles, 2014b;Hatami et al, 2016;Rigon et al, 2020;Torra et al, 2021a;Torra et al, 2021b). Of these, enhanced metabolism is one of the most important mechanisms; this may involve the enhanced activity of cytochrome P450 monooxygenases (P450s), glutathione-Stransferases (GSTs), glucosyltransferases, and ATP-binding cassette transporters (De Prado et al, 2005;Yasuor et al, 2010;Gaines et al, 2020;Palma-Bautista et al, 2020;Dimaano and Iwakami, 2021).…”

Section: Introductionmentioning

confidence: 99%

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An Asp376Glu substitution in ALS gene and enhanced metabolism confers high tribenuron-methyl resistance in Sinapis alba

Palma-Bautista

Vázquez-García²,

Osuna³

et al. 2022

Front. Plant Sci.

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Acetolactate synthase (ALS) inhibiting herbicides (group 2) have been widely applied for the last 20 years to control Sinapis alba in cereal crops from southern Spain. In 2008, a tribenuron-methyl (TM) resistant (R) S. alba population was first reported in a cereal field in Malaga (southern Spain). In 2018, three suspected R S. alba populations (R1, R2 and R3) to TM were collected from three different fields in Granada (southern Spain, 100 km away from Malaga). The present work aims to confirm the putative resistance of these populations to TM and explore their resistance mechanisms. Dose–response assays showed that the R1, R2 and R3 populations ranging between 57.4, 44.4 and 57.1 times more resistance to TM than the susceptible population (S). A mutation in the ALS gene (Asp376Glu) was detected in the Rs S. alba populations. 14C-metabolism studies show that metabolites and TM were changing significantly faster in the R than in the S plants. Alternative chemical control trials showed that 2,4-D and MCPA (auxin mimics), glyphosate (enolpyruvyl shikimate phosphate synthase,EPSPS, inhibitor-group 9), metribuzin (PSII inhibitors/Serine 264 Binders, -group 5) and mesotrione (hydroxyphenyl pyruvate dioxygenase, HPPD, inhibitor-group 27) presented a high control of the four populations of S. alba tested, both S and R. Based on these results, it is the first case described where the Asp376Glu mutation and P450-mediated metabolism participates in resistance to TM in S. alba. Comparing these results with those found in the S. alba population in Malaga in 2008, where the resistance was TSR type (Pro197Ser), we can suggest that despite the geographical proximity (over 100 km), the resistance in these cases was due to different evolutionary events.

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Section: Alternative Chemical Controlmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

An Asp376Glu substitution in ALS gene and enhanced metabolism confers high tribenuron-methyl resistance in Sinapis alba

Palma-Bautista

Vázquez-García²,

Osuna³

et al. 2022

Front. Plant Sci.

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“…Herbicide resistance is governed by target-site resistance (TSR) and non-target-site resistance (NTSR) mechanisms [ 4 ]. TSR-based resistance is caused by any gene alteration able to change the interaction with the encoded target protein/enzyme so that the herbicide is not able to sufficiently interfere with it to cause plant death.…”

mentioning

confidence: 99%

“…On the other hand, NTSR mechanisms are those not involving the target protein and can decrease the herbicide arriving at the site of action (SoA) into an insufficient amount, so plants can survive; more rarely, any mechanism protecting plants from herbicide damage is also referred as NTSR [ 5 ]. NTSR mechanisms are rarely fully understood since they can be quantitative in nature and controlled by several genes (with each gene providing some level of resistance); in other words, NTSR-based resistance can be polygenic [ 4 ].…”

mentioning

confidence: 99%

“…Sadly, this process usually occurs because resistance to one SoA provokes switching to another SoA rather than reducing herbicide-selection pressure [ 7 ]. Among NTSR mechanisms, enhanced metabolism is the most threatening because, as a generalist mechanism, it can confer cross-resistance to dissimilar herbicide chemistries, even to those never used before [ 4 ]. Conversely, TSR is governed by specialist mechanisms, always specific to a single SoA [ 5 ].…”

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confidence: 99%

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Molecular Mechanisms of Herbicide Resistance in Weeds

Torra

Cruz

2022

Genes

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Cytochrome P450CYP81A104 in Eleusine indica confers resistance to multiherbicide with different modes of action

Yao,

Yin,

et al. 2024

Pest Management Science

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BACKGROUNDDeveloping herbicide‐resistant (HR) crop cultivars is an efficient way to control weeds and minimize crop yield losses. However, widespread and long‐term herbicide application has led to the evolution of resistant weeds. Here, we established a resistant (R) E. indica population, collected from imidazolinone‐resistant rice cultivar fields.RESULTSThe R population evolved 4.5‐fold resistance to imazamox. Acetolactate synthase (ALS) gene sequencing and ALS activity assays excluded the effect of target‐site resistance in this population. P450 inhibitor malathion pretreatment significantly reversed resistance to imazamox. RNA sequencing showed that a P450 gene CYP81A104 was expressed higher in R versus susceptible (S) plants. Arabidopsis overexpressing CYP81A104 showed resistance to ALS inhibitors (imazamox, tribenuron‐methyl, penoxsulam and flucarbazone‐sodium), PSII inhibitor (bentazone), hydroxyphenyl pyruvate dioxygenase inhibitor (mesotrione) and auxin mimics (MCPA), which was generally consistent with the results presented in the R population.CONCLUSIONThis study confirmed that the CYP81A104 gene endowed resistance to multiherbicides with different modes‐of‐action. Our findings provide an insight into the molecular characteristics of resistance and contribute to formulating an appropriate strategy for weed management in HR crops. © 2024 Society of Chemical Industry.

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Editorial: Multiple Herbicide-Resistant Weeds and Non-target Site Resistance Mechanisms: A Global Challenge for Food Production

Cited by 28 publications

References 52 publications

An Asp376Glu substitution in ALS gene and enhanced metabolism confers high tribenuron-methyl resistance in Sinapis alba

An Asp376Glu substitution in ALS gene and enhanced metabolism confers high tribenuron-methyl resistance in Sinapis alba

Molecular Mechanisms of Herbicide Resistance in Weeds

Cytochrome P450CYP81A104 in Eleusine indica confers resistance to multiherbicide with different modes of action

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