Editorial: Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction

Pulmonary Congestion Due to Right and Left Heart Output Mismatching: A Case Report and Literature Review

“…Some of the pulmonary capillary vessels will be collapsed and some completely closed during CPB because of hypothermia, nonpulsatile blood flow, thromboxane A2 release, endothelin-1 secretion, complement and neutrophil activation, nuclear factorkappa B pathway, etc. (Huang et al, 1993;Komai et al, 1993;Ross and DiMarco, 2010;Yang et al, 2015;Karmouty-Quintana et al, 2018). Some of these impacts will last for a couple of days after the surgery but some may recover shortly after CPB [e.g., pulmonary vascular resistance will be increased by hypothermia and/or non-pulsatile blood flow and will quickly recover by rewarming and/or resuming pulsatile blood flow (Halsøy et al, 2016;Taylor et al, 1979].…”