Editorial/Mini-Review: Vitamin D and Prostate Cancer

Feldman, David

doi:10.1210/en.141.1.5

Cited by 49 publications

(22 citation statements)

References 16 publications

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“…VD3 could induce differentiation and cell cycle arrest in a number of malignant cells, including those in myeloid leukemia, and breast, prostate, colon, skin and brain cancer [4,5,36,37]. It has been reported that VD3 (the active form of vitamin D) significantly promoted apoptosis in the undifferentiated gastric cancer cell line HGC-27 [8].…”

Section: Discussionmentioning

confidence: 99%

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

et al. 2012

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BackgroundResults from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but the prognostic effects of its levels are unknown.Methods197 gastric carcinoma patients who received treatment in the cancer centre of Sun Yat-sen University from January 2002 to January 2006 were involved in the study. The stored blood drawn before any treatment was assayed for 25-hydroxyvitamin D levels. The clinicopathologic data were collected to examine the prognostic effects of vitamin D.ResultsThe mean vitamin D levels of the 197 gastric patients was 49.85 ± 23.68 nmol/L, among whom 114(57.9%) were deficient in Vitamin D(< 50 nmol/L), 67(34%) were insufficient (50-75 nmol/L) and 16(8.1%) were sufficient (> 75 nmol/L). Clinical stage (P = 0.004) and lymph node metastasis classification (P = 0.009) were inversely associated with vitamin D levels. The patients with high vitamin D levels group (≥ 50 nmol/L) had a higher overall survival compared with the low vitamin D levels group (< 50 nmol/L)(P = 0.018). Multivariate analysis indicated that vitamin D levels were an independent prognostic factor of gastric cancer (P = 0.019).ConclusionsVitamin D deficiency may be associated with poor prognosis in gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

et al. 2012

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“…Untreated cells have a doubling time of 18-20 h (data not shown). 4 We cannot exclude the possibility that some cell proliferation and cell death are occurring concomitantly after both radiation alone and the combination of EB 1089 with radiation. 5 Manuscript in progress: ionizing radiation-induced senescence is associated with telomere dysfunction in p53 wild-type breast tumor cells.…”

Section: Induction Of Senescence By Fractionated Irradiationmentioning

confidence: 98%

Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089

DeMasters

Gupta

Jones

et al. 2004

The Journal of Steroid Biochemistry and Molecular Biology

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“…A study in Greece concluded that the prostate cancer incidence rate could be reduced by 41% (95% con dence interval 23-59%) if individuals reduced their intake of dairy products, increased their consumption of tomatoes, and substituted olive oil for other added lipids [9]. Vitamin D and solar ultraviolet-B radiation also appear to play a protective role [10][11][12]. Comprehensive reviews of the nutritional risk factors for prostate cancer are given in [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A Multi-country Ecological Study of Dietary Risk and Risk-reduction Factors for Prostate Cancer

Grant¹

2002

Journal of Nutritional & Environmental Medicine

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Purpose: To investigate dietary factors for prostate cancer mortality (PrCM). Design: An ecological analysis was performed using age-strati ed multi-country PrCM rates and dietary supply data. Materials and Methods: The PrCM rate data were obtained from the World Health Organization. The dietary supply data were obtained from the Food and Agriculture Organization of the United Nations. Multivariate regression analyses were performed with groupings of countries based on geopolitical associations. A time lag between diet and mortality of up to 19 years was used.Results: The consumption of vegetable protein was found to be an important risk-reduction factor for PrCM as one factor in a multivariate regression analysis. In addition, a high consumption of vegetable products as a fraction of total energy was inversely correlated with PrCM. In contrast, a high consumption of animal products as a fraction of total energy, animal fat, the non-fat portion of milk, and added sugar, was found to be a risk factor for PrCM. Conclusions: This study supports previous ndings for milk and calcium, animal fat, animal products, vegetables and vegetable products, and extends the literature with the nding that added sugar is an important risk factor. The high inverse correlation between PrCM and the consumption of vegetable protein is probably due to the high iso avonoids and lignan content in foods such as pulses (beans) and whole grains. Animal products, which induce the expression of insulin-like growth factor-1, and dietary sweeteners, which also increase insulin production, may enhance prostate cancer development and subsequent mortality. It is hoped that these results will be tested in case-control and cohort studies.

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Editorial/Mini-Review: Vitamin D and Prostate Cancer

Cited by 49 publications

References 16 publications

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089

A Multi-country Ecological Study of Dietary Risk and Risk-reduction Factors for Prostate Cancer

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