Editorial: Mesothelial Physiology and Pathophysiology

Zarogiannis, Sotirios G.

doi:10.3389/fphys.2018.00263

Cited by 1 publication

(2 citation statements)

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“…On the other hand, loss of mesothelium, found in 20 out of 22 cases, was commonly observed in IPs, which could lead to a leak in the function of the mesothelial barrier potentially allowing both pericardial and interstitial fluid movement across the pericardial serosa [ 1 , 4 ], worsening the inflammatory response and resulting in recurrent effusions. Literature on canine cardiac MPH is scarce and the pathogenesis remains unknown.…”

Section: Discussionmentioning

confidence: 99%

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Pathological Findings of Canine Idiopathic Pericarditis and Pericardial Mesotheliomas: Correlation with Clinical and Survival Data

Levi

Parenti

Muscatello

et al. 2021

Veterinary Sciences

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Idiopathic pericarditis (IP) and pericardial mesothelioma (PM) are causes of pericardial effusion in dogs. Pericardiectomy can be a definitive treatment in the case of idiopathic pericardial effusion or a short-term intervention for mesothelioma. The aim of the present study was to investigate which histopathologic parameters are correlated with clinical outcomes in a cohort of dogs that underwent pericardiectomy. The histopathological findings of 22 IPs and 5 PMs were compared with clinical and survival data and the immunohistochemical characterization of immune cells (CD3, CD79α, Iba1). In IP, the mesothelium was lost in 20 cases, reactive in 9, atypical in 3, and mesothelial papillary hyperplasia (MPH) was observed in 4 cases. Numerous macrophages were found in both IPs and PMs especially at the superficial layer of the pericardium. T lymphocytes were observed in mild to moderate numbers and were more numerous than B lymphocytes in both IPs and PMs. MPH was correlated with the quantity of lymphoplasmacytic infiltrate in the superficial layer, inversely related to the thickness of the pericardium, and associated with a longer overall survival. Pericardial fibrosis was present in 19 out of 22 IPs and in all mesotheliomas and was correlated with increased time from initial presentation and pericardiectomy and lymphoplasmacytic infiltrate in the deep zone. Pericardial thickness was correlated with the amount of lymphoplasmacytic and macrophagic infiltrate in the deep zone. Mesothelioma was associated with an increased number of pericardiocentesis procedures before pericardiectomy and with the presence of macrophages in the superficial pericardial layer, edema, fibrin, and hemorrhage. Disease-free interval and overall survival were significantly shorter in patients with mesothelioma compared with IP.

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Section: Discussionmentioning

confidence: 99%

“…Pericardial diseases comprise a wide spectrum of conditions of both infectious and non-infectious etiology. Despite this, the pericardium is considered the most neglected research topic in mesothelial membrane research [ 1 ].…”

Section: Introductionmentioning

confidence: 99%