Editorial: Mechanical Loading and Bone

Tobias, Jonathan H.

doi:10.3389/fendo.2015.00184

Cited by 2 publications

(1 citation statement)

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“…Mechanical loading, also often termed as PS, is an important trigger inducing structural adaptation in bone. Multitudes of studies have investigated the effects of PS on bone, including the identification of loading regimes supporting healthy tissue homeostasis (or reversely degeneration-associated matrix loss), analysis of underlying mechanotransduction mechanisms, as well as elucidation of load-induced molecular responses ( 1 – 5 ). Nowadays, it is widely accepted that osteocytes are the main sensors of mechanical forces and orchestrate the activity of osteoblasts (responsible for bone formation) and osteoclasts (responsible for bone resorption) by several signaling pathways ( 6 ).…”

Section: Physical Stress (Ps): a Brief Summarymentioning

confidence: 99%

Stress and Alterations in Bones: An Interdisciplinary Perspective

et al. 2017

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Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.

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Section: Physical Stress (Ps): a Brief Summarymentioning

confidence: 99%

Stress and Alterations in Bones: An Interdisciplinary Perspective

et al. 2017

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Injectable BMP-2 delivery system based on collagen-derived microspheres and alginate induced bone formation in a time- and dose-dependent manner

Mumcuoglu

Fahmy-Garcia

Ridwan

et al. 2018

eCM

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The aim of the current study was to reduce the clinically used supra-physiological dose of bone morphogenetic protein-2 (BMP-2) (usually 1.5 mg/mL), which carries the risk of adverse events, by using a more effective release system. A slow release system, based on an injectable hydrogel composed of BMP-2-loaded recombinant collagen-based microspheres and alginate, was previously developed. Time- and dose-dependent subcutaneous ectopic bone formation within this system and bone regeneration capacity in a calvarial defect model were investigated. BMP-2 doses of 10 µg, 3 µg and 1 µg per implant (50 µg/mL, 15 µg/mL and 5 µg/mL, respectively) successfully induced ectopic bone formation subcutaneously in rats in a time- and dose-dependent manner, as shown by micro-computed tomography (µCT) and histology. In addition, the spatio-temporal control of BMP-2 retention was shown for 4 weeks in vivo by imaging of fluorescently-labelled BMP-2. In the subcritical calvarial defect model, µCT revealed a higher bone volume for the 2 µg of BMP-2 per implant condition (50 µg/mL) as compared to the lower dose used (0.2 µg per implant, 5 µg/mL). Complete defect bridging was obtained with 50 µg/mL BMP-2 after 8 weeks. The BMP-2 concentration of 5 µg/mL was not sufficient to heal a calvarial defect faster than the empty defect or biomaterial control without BMP-2. Overall, this injectable BMP-2 delivery system showed promising results with 50 µg/mL BMP-2 in both the ectopic and calvarial rat defect models, underling the potential of this composite hydrogel for bone regeneration therapies.

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Editorial: Mechanical Loading and Bone

Cited by 2 publications

References 0 publications

Stress and Alterations in Bones: An Interdisciplinary Perspective

Stress and Alterations in Bones: An Interdisciplinary Perspective

Injectable BMP-2 delivery system based on collagen-derived microspheres and alginate induced bone formation in a time- and dose-dependent manner

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