Editorial: Lanthanide compounds for therapeutic and diagnostic applications

Thompson, Katherine H.; Orvig, Chris

doi:10.1039/b606622b

Cited by 46 publications

(20 citation statements)

References 2 publications

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“…Nanoparticles or nanorods have been widely used for useful research tools, advanced drug delivery systems (DDS), and new ways to detect and treat disease or repair damaged tissues and cells (Alivisatos et al , 1996; Bruchez et al , 1998; Parak et al , 2003; Alivisatos, 2004; Gao et al , 2004; Thrall, 2004; Gao et al , 2005; Jain, 2005a; Jain, 2005b; Medintz et al , 2005; Michalet et al , 2005; Prescher and Bertozzi, 2005; Patra et al , 2008a; Patra et al , 2008b; Patra et al , 2008c). In this context, several groups including our group have demonstrated that lanthanide (Eu, Tb, Gd) elements/nanoparticles play important roles in biology and medicine due to their unique physical, chemical, and electronic properties (Misra et al , 2004; Sigel and Sigel, 2004; Authors, 2006; Patra et al , 2006; Thompson and Orvig, 2006; Yu et al , 2006; Patra et al , 2007; Patra et al , 2008b; Patra et al , 2009). Recently, we have demonstrated that europium hydroxide [Eu III (OH) 3 ] nanorods (inorganic nanorods) exhibit significant pro-angiogenic activities (Patra et al , 2008b).…”

Section: Introductionmentioning

confidence: 99%

In vivo toxicity studies of europium hydroxide nanorods in mice

Patra

Moneim

Wang

et al. 2009

Toxicology and Applied Pharmacology

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Lanthanide nanoparticles and nanorods have been widely used for diagnostic and therapeutic applications in biomedical nanotechnology due to their fluorescence properties and pro-angiogenic to endothelial cells, respectively. Recently, we have demonstrated that europium (III) hydroxide [Eu III (OH) 3 ] nanorods, synthesized by the microwave technique and characterized by several physico-chemical techniques, can be used as pro-angiogenic agents which introduce future therapeutic treatment strategies for severe ischemic heart/limb disease, and peripheral ischemic disease. The toxicity of these inorganic nanorods to endothelial cells was supported by several in vitro assays. To determine the in vivo toxicity, these nanorods were administered to mice through intraperitoneal injection (IP) everyday over a period of seven days in a dose dependent (1.25 to 125 mgKg −1 day −1 ) and time dependent manner (8-60 days). Bio-distribution of europium elements in different organs was analyzed by inductively coupled plasma mass spectrometry (ICPMS). Shortterm (S-T) and long-term (L-T) toxicity studies (mice sacrificed on day 8 and 60 for S-T and L-T, respectively) show normal blood hematology and serum clinical chemistry with the exception of a slight elevation of liver enzymes. Histological examination of nanorod treated vital organs (liver, kidney, spleen and lungs) showed no or only mild histological changes that indicate mild toxicity at the higher dose of nanorods.

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Section: Introductionmentioning

confidence: 99%

In vivo toxicity studies of europium hydroxide nanorods in mice

Patra

Moneim

Wang

et al. 2009

Toxicology and Applied Pharmacology

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“…Cationic lanthanum (La 3+ ) also binds to the G protein‐coupled CaR and may affect the osteoblast‐like differentiation in VSMCs. In recent years, lanthanide compounds have attracted intensive research interest in medical applications [Fricker, 2006; Thompson and Orvig, 2006]. Lanthanum carbonate is currently used in the treatment of hyperphosphatemia of chronic renal failure [Berns and Korbin, 2006].…”

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confidence: 99%

Lanthanum suppresses osteoblastic differentiation via pertussis toxin‐sensitive G protein signaling in rat vascular smooth muscle cells

Shi

Wang

Huang

et al. 2009

J of Cellular Biochemistry

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A major cellular event in vascular calcification is the phenotypic transformation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells. After demonstrating that lanthanum chloride (LaCl(3)) suppresses hydrogen peroxide-enhanced calcification in rat calcifying vascular cells (CVCs), here we report its effect on the osteoblastic differentiation of rat VSMCs, a process leading to the formation of CVCs. Cells were isolated from aortic media of male SD rats, and passages between three and eight were cultured in Dulbeccol's Modified Eagle's Medium (DMEM) containing 10% fetal bovine serum (FBS) and 10 mM beta-glycerophosphate (beta-GP) in the presence or absence of LaCl(3). Exposure of cells to LaCl(3) suppressed the beta-GP-induced elevations in calcium deposition, alkaline phosphatase (ALP) activity, and Cbfa1/Runx2 expression, as well as the concomitant loss of SM alpha-actin. Furthermore, LaCl(3) activated the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), and the blockage of either pathway with a specific inhibitor abolished the effects of LaCl(3). In addition, pretreatment of the cells with pertussis toxin (PTx), an inhibitor of G protein-mediated signaling pathway, repealed all the changes induced by LaCl(3). These findings demonstrate that LaCl(3) suppresses the beta-GP-induced osteoblastic differentiation and calcification in rat VSMCs, and its effect is mediated by the activation of both ERK and JNK MAPK pathways via PTx-sensitive G proteins.

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“…Such is the diversity of this field that their application reaches from magnetic resonance imaging and cell labelling 1,2 , to potential building blocks of quantum computers 3 . The pursuit of such applications relies on detailed knowledge of the magnetic anisotropy, which, while being completely defined in cases of high symmetry, is difficult to elucidate in low-symmetry complexes.…”

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confidence: 99%

An electrostatic model for the determination of magnetic anisotropy in dysprosium complexes

et al. 2013

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Understanding the anisotropic electronic structure of lanthanide complexes is important in areas as diverse as magnetic resonance imaging, luminescent cell labelling and quantum computing. Here we present an intuitive strategy based on a simple electrostatic method, capable of predicting the magnetic anisotropy of dysprosium(III) complexes, even in low symmetry. The strategy relies only on knowing the X-ray structure of the complex and the well-established observation that, in the absence of high symmetry, the ground state of dysprosium(III) is a doublet quantized along the anisotropy axis with an angular momentum quantum number m J ¼ ± 15 / 2 . The magnetic anisotropy axis of 14 low-symmetry monometallic dysprosium(III) complexes computed via high-level ab initio calculations are very well reproduced by our electrostatic model. Furthermore, we show that the magnetic anisotropy is equally well predicted in a selection of low-symmetry polymetallic complexes.

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Editorial: Lanthanide compounds for therapeutic and diagnostic applications

Abstract: The medical applications of lanthanides are diverse: MRI contrast agents, hypophosphatemic agents for kidney dialysis patients, luminescent probes in cell studies, and for palliation of bone pain in osteosarcoma.

Cited by 46 publications

References 2 publications

In vivo toxicity studies of europium hydroxide nanorods in mice

In vivo toxicity studies of europium hydroxide nanorods in mice

Lanthanum suppresses osteoblastic differentiation via pertussis toxin‐sensitive G protein signaling in rat vascular smooth muscle cells

An electrostatic model for the determination of magnetic anisotropy in dysprosium complexes

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