Currently, there are concerns about the fragmented teaching of science. Thus, interdisciplinary teaching is assumed as a trend, capable of presenting students with a vision of the whole, closer to reality. In this sense, this article seeks to describe the planning of an interdisciplinary artifact designed to promote the articulation of knowledge from the Natural Sciences. It is an excerpt from a master's research, completed last year. It is a descriptive research, guided by the theoretical-methodological assumptions of Design-based Research. Here, the description of the process is specifically presented with regard to the following steps: formation of the design group; identification and analysis of the problem in the school context; analysis and search for solutions; construction and organization of the educational artifact. As a result, the organization and planning of an interdisciplinary work on the Radiation and Radioactivity theme is presented, highlighting the potential, weaknesses and challenges of the process. It is believed that this work can help researchers and professors who aim to carry out interdisciplinary projects and promote the articulation of knowledge in their practices. Furthermore, as much as this work deals with the disciplines of Natural Sciences, the way it was carried out can be replicated for articulation of concepts referring to other areas of knowledge, or even for the articulation between different areas of knowledge.