Editorial: Insights in neuropathic pain: 2022

Shan, Liang; Selvarajah, Dinesh; Wang, Zilong

doi:10.3389/fpain.2023.1232025

Cited by 1 publication

(1 citation statement)

References 10 publications

(10 reference statements)

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“…Simultaneously, a high-speed camera positioned underneath the platform captured images of each step, which were then transmitted to the analysis software (version 10.6, CatWalk XT, Noldus) for further processing. In this study, eight parameters were identified to assess dynamic behaviors relevant to neuropathic pain: (1) Stand: this parameter represents the duration (in seconds) of a paw touching the glass plate; (2) Stand index: it describes the speed at which the paw moves away from the glass plate; F (1, 66) = 67.97, P < 0.0001, n SNI = 7, n SNI+HFTS = 7; Two-way ANOVA followed by post hoc comparison using the Šídák's multiple comparisons test (Supplement Table 1). (h) The application of HFTS does not change the activation curves of the Kv currents.…”

Section: Catwalk Gait Analysismentioning

confidence: 99%

High Frequency Terahertz Stimulation Alleviates Neuropathic Pain by Inhibiting the Pyramidal Neuron Activity in the Anterior Cingulate Cortex of mice

Peng,

Wang,

Tan

et al. 2024

Preprint

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Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory system and is characterized by abnormal hypersensitivity to stimuli and nociceptive responses to non-noxious stimuli, affecting approximately 7–10% of the general population. However, current first-line drugs like non-steroidal anti-inflammatory agents and opioids have limitations, including dose-limiting side effects, dependence, and tolerability issues. Therefore, developing new interventions for the management of NP is urgent. In this study, we discovered that the high-frequency terahertz stimulation (HFTS) at approximate 36 THz effectively alleviates NP symptoms in mice with spared nerve injury.In vivoandin vitroresults demonstrate that HFTS reduces the excitability of pyramidal neurons in the anterior cingulate cortex through enhancing the voltage-gated K+(Kv) conductance. Computational simulation suggests that the frequency resonates with the carbonyl group in the filter region of Kv1.2 channels, facilitating the translocation of potassium ions. This research presents a novel optical intervention strategy with terahertz waves for the treatment of NP and holds promising application in other nervous system diseases.

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Section: Catwalk Gait Analysismentioning

confidence: 99%