Editorial: Insights in genome editing tools and mechanisms: 2022

Jiang, Chanjuan; She, Qunxin; Wang, Hailong

doi:10.3389/fgeed.2023.1240576

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Genome editing is an indispensable tool for modulating specific functions of individual genes or changing the expression of important genes in the cells and whole organisms. CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) is a pivotal prokaryotic adaptive immune machinery that protects the microbiome from invading viruses and plasmids [ 123 , 124 ]. The CRISPR/Cas system represents a major driving force and a game-changer in the life science revolution in the 21st century due to its advantages in genome editing and regulation.…”

Section: The New Gems Can Change the Long-term Natural Evolution Of T...mentioning

confidence: 99%

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Lerner,

Benzvi,

Vojdani

2024

Microorganisms

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Gut luminal dysbiosis and pathobiosis result in compositional and biodiversified alterations in the microbial and host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), and the acquisition of new traits can be achieved through the exchange of mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break the harmonized balance in the intestinal compartment. The present objectives are: 1. To reveal the role played by the GEMs’ horizontal gene transfers in changing the landscape of the enteric microbiome eubiosis 2. To expand on the potential detrimental effects of those changes on the human genome and health. A search of articles published in PubMed/MEDLINE, EMBASE, and Scielo from 2000 to August 2023 using appropriate MeSH entry terms was performed. The GEMs’ horizontal gene exchanges might induce multiple human diseases. The new GEMs can change the long-term natural evolution of the enteric pro- or eukaryotic cell inhabitants. The worldwide regulatory authority’s safety control of GEMs is not enough to protect public health. Viability, biocontainment, and many other aspects are only partially controlled and harmful consequences for public health should be avoided. It is important to remember that prevention is the most cost-effective strategy and primum non nocere should be the focus.

show abstract

Section: The New Gems Can Change the Long-term Natural Evolution Of T...mentioning

confidence: 99%

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Lerner,

Benzvi,

Vojdani

2024

Microorganisms

View full text Add to dashboard Cite

show abstract

“…Genome editing is an indispensable tool for modulating specific functions of individual genes or changing the expression of important genes in the cells and whole organ-isms. CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPRassociated) is a pivotal prokaryotic adaptive immune machinery that protects the microbiome from invading viruses and plasmids [123,124]. The CRISPR/Cas system represents a major driving force and a game-changer in the life science revolution in the 21st century due to its advantages in genome editing and regulation.…”

Section: The New Gems Can Change the Long-term Natural Evolution Of T...mentioning

confidence: 99%

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Lerner,

Benzvi,

Vojdani

2024

Preprint

View full text Add to dashboard Cite

Gut luminal dysbiosis and pathobiosis result in compositional and biodiversify alterations in the microbial and host co-metabolites. The main mechanism of bacterial evolution is horizontal gene transfer (HGT) and acquisition of new traits can be achieved through mobile genetic element (MGEs) exchange. Introducing genetically engineered microbes (GEMs) might break the harmonized balance in the intestinal compartment. The present objectives are: 1. To reveal the role played by GEMs' horizontal gene transfers in changing the landscape of the enteric microbiome eubiosis 2. To expand on the potential detrimental effects of those changes on human genome and health. A search of articles published in PubMed/MEDLINE, EMBASE, and Scielo from 2000 to august 2023, using appropriate MeSH entry terms were performed. GEMs' horizontal gene exchanges might induce multiple human diseases. The new GEMs can change the long-term natural evolution of the enteric pro- or eukaryotic cells inhabitants. The worldwide regulatory authority's safety control of GEMs is not enough to protect public health. Viability and biocontainment and many other aspects are only partially controlled and harmful consequences for public health should be avoided. Always remember that prevention is the most cost- effective strategy and "primum non nocere" is the name of the game.

show abstract

Editorial: Insights in genome editing tools and mechanisms: 2022

Cited by 2 publications

References 5 publications

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

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