Editorial: Immunoglobulin Therapy in the 21st Century – the Dark Side of the Moon

Farrugia, Albert; Visentini, Marcella; Quinti, Isabella

doi:10.3389/fimmu.2015.00436

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Common variable immune deficiencies (CVID) are a group of diseases whose complexity in clinical presentation and treatment poses difficulties in management [ 1 ]. Significant progress has been made over the past few decades in awareness, early diagnosis, and therapeutic options, including immunoglobulin replacement therapy (IgRT), which have led to a profound change in the approach to affected patients [ 2 , 3 ]. The advent of intravenously administered polyvalent immunoglobulin preparations (IVIG) in the 1980s dramatically decreased morbidity and mortality and replacement therapy is universally considered to be life-saving.…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life in Patients with CVID Under Different Schedules of Immunoglobulin Administration: Prospective Multicenter Study

et al. 2019

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Objective We assessed the health-related quality of life (HRQoL) in CVID adults receiving different schedules of immunoglobulin replacement therapy (IgRT) by intravenous (IVIG), subcutaneous (SCIG), and facilitated (fSCIG) preparations. For these patients, IgRT schedule was chosen after a period focused on identifying the most suitable individual option. Methods Three hundred twenty-seven participants were enrolled in a prospective, observational, 18-month study. Participants received IgRT for at least 2 years. The first 6 months were devoted to the educational process during which the choices related to IgRT were regularly re-assessed, and the shift to alternative regimen was permitted. During the following 12 months, clinical data were prospectively collected, and only patients who did not further modify their IgRT schedule were included in the analysis of HRQoL measured by CVID_QoL, a specific instrument, and by GHQ-12, a tool to assess minor psychiatric nonpsychotic disorders. Results Three hundred four patients were included in the analysis. CVID_QoL global score and its dimensions (emotional functioning, relational functioning, gastrointestinal symptoms) were similar in IVIG, SCIG, and fSCIG recipients. Patients receiving IgRT by different routes of administration reported similar capacity to make long-term plans, discomfort due to therapy, and concern to run out of medications. Multivariate analysis revealed the GHQ-12 status, but not the IgRT mode of administration, as the major factor impacting on treatment-related QoL items, and a significant impact of age on discomfort related to IgRT. Conclusions IgRT schedules do not impact the HRQoL in CVID if the treatment is established after an extensive educational period focused on individualizing the best therapeutic regimen. Electronic supplementary material The online version of this article (10.1007/s10875-019-0592-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%