Editorial: Identifying Colonic Motor Dysfunction in Chronic Constipation with High-Resolution Manometry: Pan-Colonic Pressurizations

Bharucha, Adil E.

doi:10.1038/ajg.2016.601

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…[ 43 , 52 ] Furthermore, high-resolution manometry (HRM) has been applied to assess colonic motor dysfunction in chronic constipation by its closely spaced pressure sensors. [ 53 , 54 ] Four patterns of anorectal manometry are summarized in Fig. 1 for the dyssynergic defecation.…”

Section: Diagnosismentioning

confidence: 99%

Chronic constipation

Forootan¹,

2018

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Background:Chronic constipation is described as a common complication determined by difficult and/or rare passage of stool or both. The difference in definition of constipation has led to a wide range of reported prevalence (i.e., between 1% and 80%). Various factors are involved in the pathogenesis of the disease, including type of diet, genetic predisposition, colonic motility, absorption, social economic status, daily behaviors, and biological and pharmaceutical factors. Diagnostic and therapeutic options play a key role in the treatment of chronic constipation. There are still debates about the timing of these diagnostic and therapeutic algorithms.Methods:A systematic and comprehensive search will be performed using MEDLINE, PubMed, EMBASE, AMED, the Cochrane Library and Google Scholar. Better understanding of the pathophysiology of chronic constipation and efficacy of pharmacological agent can help physicians for treating and managing symptoms.In this study, some of the old and new therapies in the treatment of chronic constipation have been studied based on the controlled studies and strong evidence. We are trying to address some of the controversial issues to manage the disease and to provide appropriate diagnostic options in an efficient and cost-effective way.Results:The results of this systematic review will be published in a peer-reviewed journal.Conclusion:To our knowledge, our study will provide an overall estimate of chronic constipation to assess controversial issues, available diagnostic and therapeutic strategies of chronic constipation.Ethics and dissemination:Ethical approval and informed consent are not required, as the study will be a literature review and will not involve direct contact with patients or alterations to patient care.

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Section: Diagnosismentioning

confidence: 99%

Chronic constipation

Forootan¹,

2018

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“…Information on the in vivo colonic environment is obtained from several sources. Manometry is used to measure the pressure patterns within the colon associated with motility and also to diagnose dysfunctions of the human colon [14][15][16][17][18]. However, translation of the pressure events within the colon to wall motion and the consequent fluid flow is not straightforward, as the viscosity of the lumen will affect the recording pressure amplitude making interpretation of data complicated [12,19].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

et al. 2020

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This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particle motion within the DCM were characterized using Positron Emission Tomography (PET) and Positron Emission Particle Tracking (PEPT), respectively. In vitro PET images showed that fluid of higher viscosity follows the wall motion with poor mixing, whereas good mixing was observed for a low viscosity fluid. PEPT data showed particle displacements comparable to the in vivo data. Increasing fluid viscosity favors the net forward propulsion of the tracked particles. The use of a floating particle demonstrated shorter residence times and greater velocities on the liquid surface, suggesting a surface wave that was moving faster than the bulk liquid. The DCM can provide an understanding of flow motion and behavior of particles with different buoyancy, which in turn may improve the design of drug formulations, whereby fragments of the dosage form and/or drug particles are suspended in the proximal colon.

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“…Толстокишечная манометрия основана на регистрации давления в толстой кишке, некоторые исследователи не выделяют ee как отдельный метод, а считают вариантом аноректальной манометрии. Толстокишечная манометрия выявляет двигательные расстройства толстой кишки, такие как снижение двигательной активности и фазовых сократительных реакций на прием пищи и/или на прием некоторых слабительных препаратов [24,27]. В аноректальной манометрии могут использоваться катетеры или водно-перфузионные, или с твердотельными датчиками.…”

Section: методы диагностики аноректальных нарушенийunclassified

“…Дефекография с барием и магнитно-резонансная дефекография -методы диагностики для оценки особенностей опорожнения прямой кишки, которые представляют дополнительную ценность для оценки функциональных нарушений, сопровождающихся запорами, а также ректоцеле с задержкой стула, диссинергии мышц тазового дна и определении степени опорожнения прямой кишки [3,26]. Рентгенографическая дефекография помогает получить изображения и оценить функцию прямой кишки и мышц области таза во время попытки дефекации, магнитно-резонансная дефекография позволяет дополнительно оценить окружающие прямую кишку органы и ткани [27]. Следует отметить, что отсутствие стандартизации методик ограничивает их применение, особенно для магнитно-резонансной дефекографии.…”

Section: методы диагностики аноректальных нарушенийunclassified

Diagnosis of Functional Gastrointestinal Disorders and Choice of Treatment Regimen in Constipation Patients

Маев

Казюлин

Кучерявый

et al. 2021

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. A practical review of functional gastrointestinal disorder diagnosis in constipation patients and the rationale for opting treatment.Key points. Functional constipation commonly afflicts different ages and negatively impacts the quality of life. The current diagnostic algorithm in chronic constipation includes the disease identification according to Rome Criteria IV, red-flag symptom detection and instrumental laboratory examination. Functional constipation is notably often associated with anorectal abnormalities that bear a diagnostic value to elaborate an apt treatment strategy. Anorectal manometry, rectal sensation and balloon expulsion tests are the well-studied and significant probing techniques for objective anorectal zone sensorimotor function assessment in patients with functional constipation. The article reviews modern diagnostic methods in functional defecation disorders.Conclusion. The examination and treatment algorithms presented will help improve diagnosis and apply the most suitable management in a constipation-associated functional digestive pathology.

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Editorial: Identifying Colonic Motor Dysfunction in Chronic Constipation with High-Resolution Manometry: Pan-Colonic Pressurizations

Cited by 6 publications

References 23 publications

Chronic constipation

Chronic constipation

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

Diagnosis of Functional Gastrointestinal Disorders and Choice of Treatment Regimen in Constipation Patients

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