Editorial: Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Ibáñez, Agustín; Sedeño, Lucas; García, Adolfo M.; Deacon, Robert M. J.; Cogram, Patricia

doi:10.3389/fnagi.2018.00095

Cited by 11 publications

(10 citation statements)

References 36 publications

(45 reference statements)

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“…Lifelong exposure to interacting genetic and environmental factors associated with increased risk of dementia 29–32 could drive the phenotypic heterogeneity of dementia in LACs 1,7–10,33 . At the genetic level, LACs host population isolates of rare gene mutations 2,4–6,33 that cause neurodegenerative diseases (eg, familial AD, Huntington disease, ataxia, Parkinson disease, and frontotemporal dementia, and so on 7,34–55 ). Such highly informative groups may be more common than currently known due to ancestry and admixed genetic backgrounds 1,8,35 .…”

Section: Knowledge Creationmentioning

confidence: 99%

“…For many decades, regional research has been limited by lower levels of production, restricted financial and human resources, lack of government support, and almost absent policies, interventions, or national plans 87,88 . With some exceptions, most active groups develop short‐term research agendas and work in isolation without support from international initiatives 89 . Among some selected regional initiatives identified in this work (see Annex 3 for representative research projects in the region, and Figure 2.C), we found isolated efforts, replication of studies from HICs without adequate harmonization and adaptation to local contexts, and a lack of regional research targeting dementia policies.…”

Section: Knowledge Creationmentioning

confidence: 99%

“…The implementation of a network for translational research (LAC‐NTR) will require the harmonization of resources and logistics, formulation of regional standardized data‐sharing guidelines, 110 training of human resources, and promotion of a culture of collaboration. Some research groups are already working on relevant clinical issues in dementia 8,33 (Figure 2.C, Annex 3). The actions promoted by LAC‐NTR are:…”

Section: Plan Formulationmentioning

confidence: 99%

See 2 more Smart Citations

Dementia in Latin America: Paving the way toward a regional action plan

Parra¹,

Báez²,

Sedeño³

et al. 2020

Alzheimer's & Dementia

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121

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Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

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Section: Knowledge Creationmentioning

confidence: 99%

Section: Knowledge Creationmentioning

confidence: 99%

Section: Plan Formulationmentioning

confidence: 99%

See 1 more Smart Citation

Dementia in Latin America: Paving the way toward a regional action plan

Parra¹,

Báez²,

Sedeño³

et al. 2020

Alzheimer's & Dementia

Self Cite

121

View full text Add to dashboard Cite

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“…Other possible explanations may be genetic polymorphism in the degus that causes variation in enzymes which may in turn have implications on metabolic and neurological functions (Carter et al, 1972;Gurney et al, 1986;Quan et al, 2009). Inbreeding of laboratory-bred degus may also display different co-morbidities and exposure to stress compared to wild-captured bred degus (Palacios and Lee, 2013;Ibanez et al, 2018). Therefore, we conducted this investigation using tissues from a colony of degus that had occurrence of Aβ peptides and phosphorylated tau in adult animals, and animals that had behavioral testing to infer their neurological status.…”

Section: Introductionmentioning

confidence: 99%

Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus

et al. 2020

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Accumulation of amyloid-beta (Aβ) peptides is regarded as the hallmark of neurodegenerative alterations in the brain of Alzheimer's disease (AD) patients. In the eye, accumulation of Aβ peptides has also been suggested to be a trigger of retinal neurodegenerative mechanisms. Some pathological aspects associated with Aβ levels in the brain are synaptic dysfunction, neurochemical remodeling and glial activation, but these changes have not been established in the retina of animals with Aβ accumulation. We have employed the Octodon degus in which Aβ peptides accumulated in the brain and retina as a function of age. This current study investigated microglial morphology, expression of PSD95, synaptophysin, Iba-1 and choline acetyltransferase (ChAT) in the retina of juvenile, young and adult degus using immunolabeling methods. Neurotransmitters glutamate and gamma-aminobutyric acid (GABA) were detected using immunogold labeling and glutamate receptor subunits were quantified using Western blotting. There was an age-related increase in presynaptic and a decrease in post-synaptic retinal proteins in the retinal plexiform layers. Immunolabeling showed changes in microglial morphology characteristic of intermediate stages of activation around the optic nerve head (ONH) and decreasing activation toward the peripheral retina. Neurotransmitter expression pattern changed at juvenile ages but was similar in adults. Collectively, the results suggest that microglial activation, synaptic remodeling and neurotransmitter changes may be consequent to, or parallel to Aβ peptide and phosphorylated tau accumulation in the retina.

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“…Environmental factors seem to be critical for dementia presentation in the region. SDH may selectively impact dementia in LAC ( 11 , 12 ) by modulating cognitive progression and brain health burden. However, available reports on SDH have not used sophisticated cognitive and imaging measures, and scant evidence comes from LAC ( 2 , 11 ).…”

Section: Dementia Research In Latin America: Toward Unraveling the Unmentioning

confidence: 99%

The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

et al. 2021

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Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.

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Editorial: Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Cited by 11 publications

References 36 publications

Dementia in Latin America: Paving the way toward a regional action plan

Dementia in Latin America: Paving the way toward a regional action plan

Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus

The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

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