Editorial: Frontier Views in Designing Therapeutic Candidates for Management of Diverse Diseases

Kamal, Mohammad Amjad; Greig, Nigel H.

doi:10.2174/1381612823999170201155228

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…The process of DNA methylation, in turn, is connected with glucose metabolism, and insulin resistance. Moreover, it is also involved in β cell dysfunction—that is why altered or abnormal DNA methylation ultimately leads to the pathogenesis of diabetes [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study

Burzyńska-Pędziwiatr

Jankowski

Kowalski³

et al. 2020

IJMS

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In the reported study we applied the targeted metabolomic profiling employing high pressure liquid chromatography coupled with triple quadrupole tandem mass spectrometry (HPLC–MS/MS) to understand the pathophysiology of gestational diabetes mellitus (GDM), early identification of women who are at risk of developing GDM, and the differences in recovery postpartum between these women and normoglycemic women. We profiled the peripheral blood from patients during the second trimester of pregnancy and three months, and one year postpartum. In the GDM group Arg, Gln, His, Met, Phe and Ser were downregulated with statistical significance in comparison to normoglycemic (NGT) women. From the analysis of the association of all amino acid profiles of GDM and NGT women, several statistical models predicting diabetic status were formulated and compared with the literature, with the arginine-based model as the most promising of the screened ones (area under the curve (AUC) = 0.749). Our research results have shed light on the critical role of arginine in the development of GDM and may help in precisely distinguishing between GDM and NGT and earlier detection of GDM but also in predicting women with the increased type 2 diabetes mellitus (T2DM) risk.

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Section: Discussionmentioning

confidence: 99%

Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study

Burzyńska-Pędziwiatr

Jankowski

Kowalski³

et al. 2020

IJMS

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Polyphenols: Potential Future Arsenals in the Treatment of Diabetes

Solayman¹,

Ali²,

Alam³

et al. 2016

CPD

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Diabetes mellitus (DM) is one of the most common endocrine metabolic disorders. In addition to exercise and diet, oral anti-diabetic drugs have been used as a part of the management strategy worldwide. Unfortunately, none of the conventional anti-diabetic drugs are without side effects, and these drugs pose an economic burden. Therefore, the investigation of novel anti-diabetic regimens is a major challenge for researchers, in which nature has been the primary resource for the discovery of potential therapeutics. Many plants have been shown to act as anti-diabetic agents, in which the main active constituents are believed to be polyphenols. Natural products containing high polyphenol levels can control carbohydrate metabolism by various mechanisms, such as protecting and restoring beta-cell integrity, enhancing insulin releasing activity, and increasing cellular glucose uptake. Blackberries, red grapes, apricots, eggplant and popular drinks such as coffee, cocoa and green tea are all rich in polyphenols, which may dampen insulin resistance and be natural alternatives in the treatment of diabetes. Therefore, the aim of this review is to report on the available anti-diabetic polyphenols (medicinal plants, fruits and vegetables), their mechanisms in the various pathways of DM and their correlations with DM. Additionally, this review emphasizes the types of polyphenols that could be potential future resources in the treatment of DM via either novel regimens or as supplementary agents.

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Gymnema sylvestre for Diabetes: From Traditional Herb to Future’s Therapeutic

Tiwari

Ahmad

Baig

2017

CPD

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Diabetes has increased at an unprecedented rate and is fast emerging as a global threat worldwide. The focus on pharmacological studies pertaining to diabetes has seen a remarkable shift from conventional medicines to therapeutics employing bioactive phytomolecules from natural sources. The prospective effectiveness of natural products together with their low cost and minimal side effects has revolutionized the entire concept of drug discovery and management programs. One such beneficial herb is Gymnema sylvestre, possessing remarkable hypoglycemic properties and forms the platform of diabetes therapeutics in the traditional system of medication. The present article discusses the significance of G. sylvestre in diabetes management, the herbal-formulations from the herb together with its standardization and clinical trials on animal models, and why Peroxisome Proliferator Activated Receptor gamma (PPARγ) may serve as a prospective molecular target for Gymnemic acid analogs. Such studies would define the molecular basis of bioactive molecules which would aid in the development of natural product based therapeutics in the treatment of diabetes.

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Editorial: Frontier Views in Designing Therapeutic Candidates for Management of Diverse Diseases

Cited by 3 publications

References 43 publications

Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study

Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study

Polyphenols: Potential Future Arsenals in the Treatment of Diabetes

Gymnema sylvestre for Diabetes: From Traditional Herb to Future’s Therapeutic

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