Editorial for “A Multi‐sequence <scp>MRI</scp> Study in Parkinson's Disease: Association Between Rigidity and Myelin”

Jeong, Jeong‐Won; Juhász, Csaba

doi:10.1002/jmri.27863

Magnetic Resonance Imaging

2021

DOI: 10.1002/jmri.27863

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Editorial for “A Multi‐sequence MRI Study in Parkinson's Disease: Association Between Rigidity and Myelin”

Jeong‐Won Jeong

Csaba Juhász

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2023

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“…p < 0.05 is marked as bold.FIGURE 1Visualization of the WM ROIs used in this study. The ROI names are listed in Table 2(Tobias et al, 2019;Jiayue et al, 2022).…”

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confidence: 99%

Sex, myelin, and clinical characteristics of Parkinson’s disease

Cai,

Kim,

Wang

et al. 2023

Front. Neurosci.

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ObjectiveTo determine if there are sex differences in myelin in Parkinson’s disease, and whether these explain some of the previously-described sex differences in clinical presentation.MethodsThirty-three subjects (23 males, 10 females) with Parkinson’s disease underwent myelin water fraction (MWF) imaging, an MRI scanning technique of in vivo myelin content. MWF of 20 white matter regions of interest (ROIs) were assessed. Motor symptoms were assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS). Principal component analysis, logistic and multiple linear regressions, and t-tests were used to determine which white matter ROIs differed between sexes, the clinical features associated with these myelin changes, and if overall MWF and MWF laterality differed between males and females.ResultsConsistent with prior reports, tremor and bradykinesia were more likely seen in females, whereas rigidity and axial symptoms were more likely seen in males in our cohort. MWF of the thalamic radiation, cingulum, cingulum hippocampus, inferior fronto-occipital fasciculi, inferior longitudinal fasciculi, and uncinate were significant in predicting sex. Overall MWF and asymmetry of MWF was greater in males. MWF differences between sexes were associated with tremor symptomatology and asymmetry of motor performance.ConclusionSex differences in myelin are associated with tremor and asymmetry of motor presentation. While preliminary, our results suggest that further investigation of the role of biological sex in myelin pathology and clinical presentation in Parkinson’s disease is warranted.

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“…p < 0.05 is marked as bold.FIGURE 1Visualization of the WM ROIs used in this study. The ROI names are listed in Table 2(Tobias et al, 2019;Jiayue et al, 2022).…”

mentioning

confidence: 99%

Sex, myelin, and clinical characteristics of Parkinson’s disease

Cai,

Kim,

Wang

et al. 2023

Front. Neurosci.

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show abstract

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Editorial for “A Multi‐sequence MRI Study in Parkinson's Disease: Association Between Rigidity and Myelin”

Cited by 1 publication

References 11 publications

Sex, myelin, and clinical characteristics of Parkinson’s disease

Sex, myelin, and clinical characteristics of Parkinson’s disease

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