Editorial: Comorbidity and Autism Spectrum Disorder

Frye, Richard E.; Gillberg, Christopher; Casanova, Manuel

doi:10.3389/fpsyt.2020.617395

Cited by 59 publications

(55 citation statements)

References 33 publications

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“…Considering that such abnormal inflammatory regulation is thought to be closely linked to the gut microbiota, dysbiosis has been suggested as a main factor responsible for ASD etiology, and this is also consistent with the comorbid gastrointestinal disturbances of ASD patients and their vulnerability to infections [ 60 , 70 , 71 , 72 ]. In support of this idea, GF animals have been reported to exhibit ASD-like traits (e.g., social avoidance and repetitive behaviors) which were rescued by association of the conventional microbiota [ 73 ], and both human patients and several ASD mouse models have been shown to have gut dysbiosis [ 65 , 74 , 75 , 76 ].…”

Section: Mgba-associated Neurological Disordersmentioning

confidence: 76%

“…ASD represents a group of neurodevelopmental disorders often diagnosed in childhood and characterized by impaired social interactions and repetitive/restrictive behaviors that are frequently accompanied by intellectual disabilities and epilepsy [ 60 ]. The etiology of ASD is both complex and heterogeneous, as ASD encompasses a range of symptoms with genetic and environmental factors contributing to its pathogenesis.…”

Section: Mgba-associated Neurological Disordersmentioning

confidence: 99%

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Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

Lee

Cho

Jeong

et al. 2021

Cells

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The microbiota–gut–brain axis (MGBA) is a bidirectional signaling pathway mediating the interaction of the microbiota, the intestine, and the central nervous system. While the MGBA plays a pivotal role in normal development and physiology of the nervous and gastrointestinal system of the host, its dysfunction has been strongly implicated in neurological disorders, where intestinal dysbiosis and derived metabolites cause barrier permeability defects and elicit local inflammation of the gastrointestinal tract, concomitant with increased pro-inflammatory cytokines, mobilization and infiltration of immune cells into the brain, and the dysregulated activation of the vagus nerve, culminating in neuroinflammation and neuronal dysfunction of the brain and behavioral abnormalities. In this topical review, we summarize recent findings in human and animal models regarding the roles of the MGBA in physiological and neuropathological conditions, and discuss the molecular, genetic, and neurobehavioral characteristics of zebrafish as an animal model to study the MGBA. The exploitation of zebrafish as an amenable genetic model combined with in vivo imaging capabilities and gnotobiotic approaches at the whole organism level may reveal novel mechanistic insights into microbiota–gut–brain interactions, especially in the context of neurological disorders such as autism spectrum disorder and Alzheimer’s disease.

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Section: Mgba-associated Neurological Disordersmentioning

confidence: 76%

Section: Mgba-associated Neurological Disordersmentioning

confidence: 99%

Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

Lee

Cho

Jeong

et al. 2021

Cells

View full text Add to dashboard Cite

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“…Early assessment of development can also serve as an important basis for follow-up assessment and treatment. Individual profile characteristics and observation of early childhood behaviors can be indicative for potential comorbidity and/or developmental abnormalities ( 27 , 28 ) that can be detected later in life. ASD is often accompanied by cognitive deficits and speech delay ( 29 ), as well as by emotional and behavioral difficulties ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

The Importance of Early Psychological Assessment for Differential Diagnosis and Detection of Comorbidity in Children With Autism Spectrum Disorder

2021

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“…As for the differences between toddlers with DS and toddlers with ASD, data confirmed our expectations. Although percentages given for the prevalence of comorbidity of psychopathology in ASD vary significantly between studies (from 11% to 84% according to Davis et al, [56]), most authors report high rates of behavioral problems and psychiatric conditions in individuals with ASD, e.g., [57,58]. The most common problems include aggression and self-injurious behavior, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, tics, depression, and anxiety, as well as eating and sleep disorders.…”

Section: Discussionmentioning

confidence: 99%

Symptoms of Autism, Comorbid Mental Health Conditions and Challenging Behaviors among Toddlers with Down Syndrome at Low Risk for ASD—Characterization Using the BISCUIT—Parts 1–3

Pisula

Niedźwiecka

2021

IJERPH

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Background: Autism spectrum disorder (ASD) may coexist with Down syndrome (DS). Most studies on this topic involve school-age children, adolescents, or adults with DS. This study looked at ASD symptoms, other mental health problems, and challenging behaviors in toddlers with DS at low risk of ASD. Methods: We used screening tools for autism in toddlers; BISCUIT–Parts 1–3 and Q-CHAT. We compared four groups of children aged 17–37 months: DS, ASD, Atypical Development (AD), and Typically Developing (TD). Results: Children with DS showed lower symptoms of ASD than children with ASD (without DS) and higher than TD children, except for repetitive behaviors/restricted interests. For comorbid mental health problems and difficult behaviors, children with DS scored lower than children with ASD. There were no differences between children with DS and TD children in this regard. Conclusions: The study results indicate that BISCUIT–Parts 1–3 are valid instruments to differentiate toddlers with DS from toddlers with ASD. However, they also show that toddlers with DS at low ASD risk are a very heterogeneous group when the ASD symptoms are considered. Autistic characteristics should be taken into account in supporting young children with this genetic condition.

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Editorial: Comorbidity and Autism Spectrum Disorder

Cited by 59 publications

References 33 publications

Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

The Importance of Early Psychological Assessment for Differential Diagnosis and Detection of Comorbidity in Children With Autism Spectrum Disorder

Symptoms of Autism, Comorbid Mental Health Conditions and Challenging Behaviors among Toddlers with Down Syndrome at Low Risk for ASD—Characterization Using the BISCUIT—Parts 1–3

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