Editorial: Clinical phytopharmacology

Willcox, Merlin L.; Tai, Chi-Jung; Chattopadhyay, Kaushik; Hu, Xiao-Yang; Heinrich, Michael

doi:10.3389/fphar.2023.1353483

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…Extracted from the fruit, ISO presents an ideal medicinal profile. However, a more in-depth and comprehensive studies on clinical utility is imperative to ascertain the safety and availability of ISO ( Willcox et al, 2024 ). Due to the complexity of the existing small components in natural products and the unclear mechanism of action, there are challenges such as difficulty in extraction and processing, as well as poor bioavailability, pose hurdles for their clinical use in treatment.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Isorhamnetin: what is the in vitro evidence for its antitumor potential and beyond?

Lei,

Yang,

Bao

et al. 2024

Front. Pharmacol.

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Isorhamnetin (ISO) is a phenolic compound belonging to flavonoid family, showcasing important in vitro pharmacological activities such as antitumor, anti-inflammation, and organ protection. ISO is predominantly extracted from Hippophae rhamnoides L. This plant is well-known in China and abroad because of its “medicinal and food homologous” characteristics. As a noteworthy natural drug candidate, ISO has received considerable attention in recent years owing to its low cost, wide availability, high efficacy, low toxicity, and minimal side effects. To comprehensively elucidate the multiple biological functions of ISO, particularly its antitumor activities and other pharmacological potentials, a literature search was conducted using electronic databases including Web of Science, PubMed, Google Scholar, and Scopus. This review primarily focuses on ISO’s ethnopharmacology. By synthesizing the advancements made in existing research, it is found that the general effects of ISO involve a series of in vitro potentials, such as antitumor, protection of cardiovascular and cerebrovascular, anti-inflammation, antioxidant, and more. This review illustrates ISO’s antitumor and other pharmacological potentials, providing a theoretical basis for further research and new drug development of ISO.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%