Editorial: Biotribology and Biotribocorrosion Properties of Implantable Biomaterials

Ruggiero, Alessandro; Zhang, Hongyu

doi:10.3389/fmech.2020.00017

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…There is limited data on the long-term effects of spinal loading on CTDR prostheses and the immune response that is initiated secondary to wear particles [33]. This presents significant challenges for developers of CTDR prostheses [34].…”

Section: Discussionmentioning

confidence: 99%

Midterm osteolysis-induced aseptic failure of the M6-C™ cervical total disc replacement secondary to polyethylene wear debris

2022

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Background According to published meta-analyses, cervical total disc replacement (CTDR) seems to be superior to anterior cervical decompression and fusion (ACDF) in most clinical parameters. Despite short-term clinical success of CTDR, there are concerns regarding long-term durability of these prostheses. Methods This prospective study involved 382 patients who received standalone CTDR or a hybrid procedure (ACDF/CTDR). A retrospective comparison between different CTDR devices was conducted regarding patient-reported outcome measures (PROMs), failure scenarios, and revision surgeries. The M6-C™ Artificial Cervical Disc (Orthofix, Lewisville, Texas) cohort was compared to the other CTDR devices clinically. Etiological reasons for revision, and the surgical technique of the revision was investigated. Results Fifty-three patients received M6-C CTDR. Eighteen patients (34%) were revised at an average of 67 months postoperatively for wear-induced osteolysis. There were three additional cases of pending revision. The PROMs of the two groups were similar, indicating that the failure mode (wear-induced osteolysis) is often asymptomatic. The demographics of the two groups were also similar, with more women undergoing revision surgery than men. There were three one-level CTDR, four two-level hybrids, seven three-level hybrids, and three four-level hybrids revised anteriorly. Sixteen patients underwent removal of the prosthesis and were treated according to the extent of osteolysis. There were four vertebrectomies, six revisions to ACDF, and six revisions to another CTDR. One patient underwent supplemental fixation using a posterior approach. The other CTDR cohort had an incidence of 3.3% at the equivalent time, and none of these were due to osteolysis or wear-related events. Conclusions There is a concerning midterm failure rate related to ultra-high-molecular-weight-polyethylene wear-induced osteolysis in the M6-C. Patients implanted with the M6-C prosthesis should be contacted, informed, and clinically and radiologically assessed.

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Section: Discussionmentioning

confidence: 99%

Midterm osteolysis-induced aseptic failure of the M6-C™ cervical total disc replacement secondary to polyethylene wear debris

2022

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“…These are lined by a fibrous capsule, which also provides stabilization to the joint and is covered by a synovial membrane devoted to synovial fluid secretion. Setting aside the complexity of the biological phenomena acting in the synovial joints, the possibility of a complete understanding of their tribological performances, accounting for the possibility of a detailed mathematical description of the contact and lubrication phenomena, could be useful to the scientists involved in both the medical or pharmacological treatment of joint diseases and also in the optimal biomechanical and tribological design of artificial joints (Popov, 2019;Ruggiero and Zhang, 2020).…”

Section: Introductionmentioning

confidence: 99%

Milestones in Natural Lubrication of Synovial Joints

Ruggiero

2020

Front. Mech. Eng.

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For years, the physical and mathematical modeling of tribological phenomena in natural human synovial joints has been a great challenge for researchers and scientists. This short review aims to summarize the main findings on lubrication modeling of human synovial joints over the years, starting from first insights and then underlining the evolution of the proposed theories. The complexity of natural human synovial joints, in which biological, fluid dynamic, and tribological phenomena takes place, makes this research area fascinating for scientists from several investigation fields. This manuscript underlines the necessity of deep scientific cooperation between researchers from different branches of the involved disciplines to achieve complete knowledge of these tribo-systems by taking in to account different points of view.

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“…However, several experimental investigations focus on improving the tribological effectiveness of joint replacements [21][22][23] and lubrication conditions in prostheses [24][25][26], some experimental investigations are complemented with computer-aided or computational methods to improve the prediction and findings [27][28][29]. Nevertheless, the exact interactions of coating process parameters and resulting properties are mostly qualitative and only valid for certain coating plants and in certain parameter ranges.…”

Section: Amorphous Carbon Coating Designmentioning

confidence: 99%

Design of Amorphous Carbon Coatings Using Gaussian Processes and Advanced Data Visualization

et al. 2022

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In recent years, an increasing number of machine learning applications in tribology and coating design have been reported. Motivated by this, this contribution highlights the use of Gaussian processes for the prediction of the resulting coating characteristics to enhance the design of amorphous carbon coatings. In this regard, by using Gaussian process regression (GPR) models, a visualization of the process map of available coating design is created. The training of the GPR models is based on the experimental results of a centrally composed full factorial 23 experimental design for the deposition of a‑C:H coatings on medical UHMWPE. In addition, different supervised machine learning (ML) models, such as Polynomial Regression (PR), Support Vector Machines (SVM) and Neural Networks (NN) are trained. All models are then used to predict the resulting indentation hardness of a complete statistical experimental design using the Box–Behnken design. The results are finally compared, with the GPR being of superior performance. The performance of the overall approach, in terms of quality and quantity of predictions as well as in terms of usage in visualization, is demonstrated using an initial dataset of 10 characterized amorphous carbon coatings on UHMWPE.

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Editorial: Biotribology and Biotribocorrosion Properties of Implantable Biomaterials

Cited by 11 publications

References 25 publications

Midterm osteolysis-induced aseptic failure of the M6-C™ cervical total disc replacement secondary to polyethylene wear debris

Midterm osteolysis-induced aseptic failure of the M6-C™ cervical total disc replacement secondary to polyethylene wear debris

Milestones in Natural Lubrication of Synovial Joints

Design of Amorphous Carbon Coatings Using Gaussian Processes and Advanced Data Visualization

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