Editorial: Bioresponsive nanomaterials for drug delivery or controlled release

Pan, Yan; Qi, Kezhen; Fu, Jijun; Gao, Wei; Zhao, Li; Lin, Zhiqiang

doi:10.3389/fbioe.2023.1165782

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…The primary principle of these scaffolds is to provide highly targeted and localized control in therapeutic drug release, thus enhancing the efficacy and safety of treatments. Bioreactivity largely depends on the properties of the polymers used to construct the scaffolds, including their pH responsiveness, temperature responsiveness, light responsiveness, electric-field responsiveness, and magnetic-field responsiveness [ 247 , 248 ].…”

Section: Multiresponse Intelligent Drug Delivery Systems Based On Nan...mentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

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Section: Multiresponse Intelligent Drug Delivery Systems Based On Nan...mentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Advancements in wound management: integrating nanotechnology and smart materials for enhanced therapeutic interventions

Nasra,

Pramanik,

Oza

et al. 2024

Discover Nano

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Wound management spans various techniques and materials tailored to address acute and chronic non-healing wounds, with the primary objective of achieving successful wound closure. Chronic wounds pose additional challenges, often necessitating dressings to prepare the wound bed for subsequent surgical procedures like skin grafting. Ideal dressing materials should not only expedite wound healing but also mitigate protein, electrolyte, and fluid loss while minimizing pain and infection risk. Nanotechnology has emerged as a transformative tool in wound care, revolutionizing the landscape of biomedical dressings. Its application offers remarkable efficacy in accelerating wound healing and combating bacterial infections, representing a significant advancement in wound care practices. Integration of nanotechnology into dressings has resulted in enhanced properties, including improved mechanical strength and controlled drug release, facilitating tailored therapeutic interventions. This review article comprehensively explores recent breakthroughs in wound healing therapies, with a focus on innovative medical dressings such as nano-enzymes. Additionally, the utilization of smart materials, like hydrogels and electroactive polymers, in wound dressings offers dynamic functionalities to promote tissue regeneration. Emerging concepts such as bio-fabrication, microfluidic systems, bio-responsive scaffolds, and personalized therapeutics show promise in expediting wound healing and minimizing scarring. Through an in-depth exploration of these advancements, this review aims to catalyze a paradigm shift in wound care strategies, promoting a patient-centric approach to therapeutic interventions.

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Editorial: Bioresponsive nanomaterials for drug delivery or controlled release

Cited by 2 publications

References 2 publications

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Advancements in wound management: integrating nanotechnology and smart materials for enhanced therapeutic interventions

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