Editorial: Autoinflammatory Keratinization Disease (AiKD)

Akiyama, Masashi; Vita, Valerio De; Sugiura, Kazumitsu

doi:10.3389/fimmu.2020.01753

Cited by 8 publications

(19 citation statements)

References 11 publications

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“…Thirty-two HS patients from the main study had 18 F-FDG PET-CT scan done. Demographic characteristics of the study population and matched control are shown in Table 1.…”

Section: Demographic and Clinical Characteristicsmentioning

confidence: 99%

“…[1][2][3][4] Although positron emission tomography-computed tomography (PET-CT) imaging is most commonly used in the oncology setting, it is also useful in nononcological setting such as the cardiac and brain imaging. The high sensitivity of 18 F-FDG PET/CT in detecting cellular inflammation in tissues and early atherosclerosis is well demonstrated. [5,6] Mehta et al demonstrated that patients with psoriasis have increased vascular inflammation in multiple aortic segments as well as increased hepatic inflammation based on 18 F-FDG PET/CT though it is not significant after being adjusted for alcohol intake.…”

Section: Introductionmentioning

confidence: 98%

“…[5,6] Mehta et al demonstrated that patients with psoriasis have increased vascular inflammation in multiple aortic segments as well as increased hepatic inflammation based on 18 F-FDG PET/CT though it is not significant after being adjusted for alcohol intake. [6] As HS is associated with systemic diseases with chronic inflammation such as psoriasis, we postulate that the use of 18 F-FDG…”

Section: Introductionmentioning

confidence: 99%

“…The findings of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography scan in patients with hidradenitis suppurativa in Malaysia: A multicenter study Point 4 and Point 5 are scored when the 'lesional' uptake is slightly moderately higher than liver and markedly increased uptake or any new lesion (subjectively set to at least 3x higher than the liver), respectively. Any non-physiological unexplained (not due to known trauma or infection) skin uptake of 18 F-FDG was considered new "active" lesion based on scan findings. Subsequently, age-and sex-matched controls comprising nuclear medicine patients of unrelated diseases without cutaneous involvement were selected (1:1 ratio).…”

Section: Introductionmentioning

confidence: 99%

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The findings of 18F-fluorodeoxyglucose positron emission tomography–computed tomography scan in patients with hidradenitis suppurativa in Malaysia: A multicenter study

et al. 2021

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Hidradenitis suppurativa (HS) is known to have association with systemic diseases with chronic inflammation such as psoriasis. We aim to describe the concomitant systemic inflammation in patients with HS using 18F-fluorodeoxyglucose positron emission tomography–computed tomography ( 18 F-FDG PET/CT) scan. This was a case–control study conducted in three tertiary hospitals in Northern Malaysia from January to December 2017, involving HS patients aged 18 years and above. Thirty-two HS patients with age- and sex-matched controls were recruited with a mean age of 31.4 years (range: 18–56). Numerous cutaneous inflammatory foci were detected on FDG-PET/CT scan in clinically unapparent sites (27/32, 84.4%). Approximately 90.6%, 93.8%, and 50.0% of the patients had significantly higher cutaneous uptake over nasal, mandibular, and scalp regions, respectively ( P < 0.0001). PET/CT scan did not detect any systemic inflammation unlike those found in psoriasis. Three (9.4%) patients had thyroid nodules with high uptake (maximum standard uptake values ranging from 2.9 to 11.3). Two of them were confirmed to have papillary thyroid carcinoma, while the third patient has inconclusive finding. 18 F-FDG PET/CT scan may be useful to map disease burden of HS. Nonlesional inflammatory foci on the skin of the nose, mandibular, and scalp are probably significant. The association of thyroid carcinoma in HS warrants further evaluation.

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“…Thirty-two HS patients from the main study had 18 F-FDG PET-CT scan done. Demographic characteristics of the study population and matched control are shown in Table 1.…”

Section: Demographic and Clinical Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The findings of 18F-fluorodeoxyglucose positron emission tomography–computed tomography scan in patients with hidradenitis suppurativa in Malaysia: A multicenter study

et al. 2021

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“…Indeed, currently, HS is included in the autoinflammatory keratinization disorders (AiKDs) [ 42 ], a subgroup of AIDs characterized by a significant interplay between various genetic factors causing autoinflammation mainly in the epidermis and in the most superficial layers of the dermis. The induced autoinflammatory responses ultimately result in an aberrantly upregulated keratinization, thus, leading to the additional inflammatory symptoms of AiKDs [ 43 ].…”

Section: Autoinflammatory Diseases With Notch Pathway Involvementmentioning

confidence: 99%

Notch Signaling Regulation in Autoinflammatory Diseases

Gratton

Tricarico

D’Adamo

et al. 2020

IJMS

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Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders.

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