Editorial: Autoantibodies

Holmdahl, Rikard; Nimmerjahn, Falk; Ludwig, Ralf J.

doi:10.3389/fimmu.2019.00484

Cited by 4 publications

(5 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These regimens include classical approaches such as plasmapheresis, rituximab, and intravenous immune globulin, and new methods such as proteasome inhibitors, complement inhibitors. 42 They have been used to treat autoimmune diseases, 43 anti-HLA antibodies in transplantation, 42,44 and AT1R-AA in transplantation. 16 Immunosuppression appears to be more effective in a preventative rather than a therapeutic role.…”

Section: Discussionsmentioning

confidence: 99%

Autoantibodies to LG3 are associated with poor long‐term survival after liver retransplantation

McAlister

House

et al. 2021

Clinical Transplantation

View full text Add to dashboard Cite

Both alloimmune and autoimmunity contribute to graft loss in organ transplantation. The detrimental roles of donor-specific antibodies (DSA) to human leukocyte antigen (HLA) are well-established in transplantation of kidney, pancreas, heart, lung, and intestine, 1-3 but less so in liver transplantation (LT). [4][5][6][7][8][9][10][11] Antibodies to non-HLA antigens, such as autoantibodies or natural polyclonal antibodies, were also described in recipients of solid organs 12 and allogeneic hematopoietic stem cells. 13 Autoantibodies, which may be generated through the exposure of cryptic antigens, are detrimental for the survival of the kidney, [14][15][16] lung, 17 heart, 18,19 liver, [20][21][22] and intestinal 23 allografts. The prevalence of antibodies to HLA and autoantigens are often higher before retransplantation than before the first transplantation, especially in recipients of kidney grafts. 24 Recipients of redo liver transplant usually have worse outcomes in comparison with recipients of first-time liver

show abstract

Section: Discussionsmentioning

confidence: 99%

Autoantibodies to LG3 are associated with poor long‐term survival after liver retransplantation

McAlister

House

et al. 2021

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…1 E ). Since the pathogenic antibodies that have been shown to be associated with various autoimmune and inflammatory disorders are of the class-switched IgG isotype ( Holmdahl et al, 2019 ; Werwitzke et al, 2005 ), we further sought to characterize the circulating IgG antibodies from the sera of Regnase-1–deficient mice. We tested binding of the circulating IgG antibodies to a panel of antigens by ELISA, which showed polyreactivity to diverse antigens, such as insulin, cardiolipin, LPS, KLH, and DNA, compared with control mice ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…During progression of autoimmune disorders, pathogenic antibodies present as switched isotypes, mostly IgG subtypes, while IgM has been associated with a protective role ( Holmdahl et al, 2019 ; Werwitzke et al, 2005 ). Given that the top up-regulated genes in the transcriptome analysis promote B cell differentiation, we sought to determine if Regnase-1–deficient B cells have an increased propensity for activation and class switching.…”

Section: Resultsmentioning

confidence: 99%

Regnase-1 is essential for B cell homeostasis to prevent immunopathology

Bhat

Virgen-Slane

Ramezani-Rad

et al. 2021

Journal of Experimental Medicine

View full text Add to dashboard Cite

Regnase-1 is an emerging regulator of immune responses with essential roles in the posttranscriptional control of immune cell activation. Regnase-1 is expressed in B cells; however, its B cell–specific functions remain unknown. Here, we demonstrate that Regnase-1 prevents severe autoimmune pathology and show its essential role in maintaining B cell homeostasis. Using Cre driver mice for ablation of Regnase-1 at various stages of B cell development, we demonstrate that loss of Regnase-1 leads to aberrant B cell activation and differentiation, resulting in systemic autoimmunity and early morbidity. The basis of these findings was informed by gene expression data revealing a regulatory role for Regnase-1 in the suppression of a transcriptional program that promotes B cell activation, survival, and differentiation. Overall, our study shows that Regnase-1 exerts critical control of B cell activation, which is required for prevention of immunopathology.

show abstract

“…Many of these autoimmune diseases are diagnosed on the basis of serological detection of autoantibodies present in the patients. The best-known antibodies among those detected are antinuclear antibodies, which are present mainly in autoimmune diseases such as systemic lupus erythematosus and systemic sclerosis [ 173 ]. When autoantibodies cannot be detected via the usual methods, novel techniques are used, such as determining specific autoantibody isotypes in suspected cases of rheumatoid arthritis [ 174 ] or using a keratinocyte-binding assay in suspected cases of pemphigus [ 175 ].…”

Section: Diagnostic Methods In Parkinson’s Disease and Alzheimer’s Di...mentioning

confidence: 99%

Review of Technological Challenges in Personalised Medicine and Early Diagnosis of Neurodegenerative Disorders

Domínguez-Fernández

Egiguren-Ortiz

Razquin

et al. 2023

IJMS

View full text Add to dashboard Cite

Neurodegenerative disorders are characterised by progressive neuron loss in specific brain areas. The most common are Alzheimer’s disease and Parkinson’s disease; in both cases, diagnosis is based on clinical tests with limited capability to discriminate between similar neurodegenerative disorders and detect the early stages of the disease. It is common that by the time a patient is diagnosed with the disease, the level of neurodegeneration is already severe. Thus, it is critical to find new diagnostic methods that allow earlier and more accurate disease detection. This study reviews the methods available for the clinical diagnosis of neurodegenerative diseases and potentially interesting new technologies. Neuroimaging techniques are the most widely used in clinical practice, and new techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have significantly improved the diagnosis quality. Identifying biomarkers in peripheral samples such as blood or cerebrospinal fluid is a major focus of the current research on neurodegenerative diseases. The discovery of good markers could allow preventive screening to identify early or asymptomatic stages of the neurodegenerative process. These methods, in combination with artificial intelligence, could contribute to the generation of predictive models that will help clinicians in the early diagnosis, stratification, and prognostic assessment of patients, leading to improvements in patient treatment and quality of life.

show abstract

Editorial: Autoantibodies

Cited by 4 publications

References 62 publications

Autoantibodies to LG3 are associated with poor long‐term survival after liver retransplantation

Autoantibodies to LG3 are associated with poor long‐term survival after liver retransplantation

Regnase-1 is essential for B cell homeostasis to prevent immunopathology

Review of Technological Challenges in Personalised Medicine and Early Diagnosis of Neurodegenerative Disorders

Contact Info

Product

Resources

About