Editor's Correspondence

Wysowski, Diane K.; Chang, Jennie

doi:10.1001/archinte.165.3.346-b

Cited by 46 publications

(13 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some patients treated with an orally or intravenously administered bisphosphonate experience bone, joint, or muscle complaints that may be severe (115 [EL 3]) but that usually resolve when use of the drug is discontinued. Osteonecrosis of the jaw (ONJ) has been associated rarely with bisphosphonate therapy for osteoporosis (116–118 [EL 4]); risk factors include dental pathologic conditions, invasive dental procedures, or poor dental hygiene.…”

Section: Evidence-based Discussion Of Recommendationsmentioning

confidence: 99%

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Postmenopausal Osteoporosis: Executive Summary of Recommendations

Watts¹,

Bilezikian²,

Camacho³

et al. 2010

Endocrine Practice

View full text Add to dashboard Cite

Section: Evidence-based Discussion Of Recommendationsmentioning

confidence: 99%

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Postmenopausal Osteoporosis: Executive Summary of Recommendations

Watts¹,

Bilezikian²,

Camacho³

et al. 2010

Endocrine Practice

View full text Add to dashboard Cite

“…The Food and Drug Administration reported severe bone, joint, and/or muscle pain, that developed in 112 women, 4 men, 1 adult of unknown sex, and 1 child after starting therapy with alendronate in 2005. [4] The age range as 7 to 84 years (N=109; median=67 years). Bones, joints, and muscles throughout the body were affected.…”

Section: Discussionmentioning

confidence: 99%

Diffuse skeletal pain after administration of alendronate

Ozaras

Rezvanı

2010

Indian J Pharmacol

View full text Add to dashboard Cite

Background:Osteoporosis is caused by bone resorption in excess of bone formation, and bisphosphonates, are used to inhibit bone resorption. Alendronate, a biphosphonate, is effective for both the treatment and prevention of osteoporosis in postmenopausal women. Side effects are relatively few and prominently gastrointestinal. Musculoskeletal pain may be an important side effect in these patients. We presented a patient admitted to our out-patient clinic with diffuse skeletal pain after three consecutive administration of alendronate.Conclusion:We conclude that patients with osteoporosis can report pain, and bisphosphonate-related pain should also be considered before ascribing this complaint to osteoporosis.

show abstract

“…The authors concluded that the user reports contained clear evidence of an association that a SRS in place at that time had not detected. In 2005, two researchers wrote a letter to the FDA about numerous reports in FAERS for bisphosphonates associated with severe bone, joint, and muscle pain[71]. Several years later, a public FDA alert lead to the further investigation by hospital staff of one case from Massachusetts General Hospital[72].…”

Section: Social Mediamentioning

confidence: 99%

Text Mining for Adverse Drug Events: the Promise, Challenges, and State of the Art

et al. 2014

View full text Add to dashboard Cite

Text mining is the computational process of extracting meaningful information from large amounts of unstructured text. Text mining is emerging as a tool to leverage underutilized data sources that can improve pharmacovigilance, including the objective of adverse drug event detection and assessment. This article provides an overview of recent advances in pharmacovigilance driven by the application of text mining, and discusses several data sources—such as biomedical literature, clinical narratives, product labeling, social media, and Web search logs—that are amenable to text-mining for pharmacovigilance. Given the state of the art, it appears text mining can be applied to extract useful ADE-related information from multiple textual sources. Nonetheless, further research is required to address remaining technical challenges associated with the text mining methodologies, and to conclusively determine the relative contribution of each textual source to improving pharmacovigilance.

show abstract

Editor's Correspondence

Cited by 46 publications

References 1 publication

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Postmenopausal Osteoporosis: Executive Summary of Recommendations

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Postmenopausal Osteoporosis: Executive Summary of Recommendations

Diffuse skeletal pain after administration of alendronate

Text Mining for Adverse Drug Events: the Promise, Challenges, and State of the Art

Contact Info

Product

Resources

About