Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms

Wanhainen, Anders; Van Herzeele, Isabelle; Bastos Goncalves, Frederico; Bellmunt Montoya, Sergi; Berard, Xavier; Boyle, Jonathan R.; D’Oria, Mario; Prendes, Carlota F.; Karkos, Christos D.; Kazimierczak, Arkadiusz; Koelemay, Mark J.W.; Kölbel, Tilo; Mani, Kevin; Melissano, Germano; Powell, Janet T.; Trimarchi, Santi; Tsilimparis, Nikolaos; Antoniou, George A.; Björck, Martin; Coscas, Raphael; Dias, Nuno V.; Kolh, Philippe; Lepidi, Sandro; Mees, Barend M.E.; Resch, Timothy A.; Ricco, Jean Baptiste; Tulamo, Riikka; Twine, Christopher P.; Branzan, Daniela; Cheng, Stephen W.K.; Dalman, Ronald L.; Dick, Florian; Golledge, Jonathan; Haulon, Stephan; van Herwaarden, Joost A.; Ilic, Nikola S.; Jawien, Arkadiusz; Mastracci, Tara M.; Oderich, Gustavo S.; Verzini, Fabio; Yeung, Kak Khee

doi:10.1016/j.ejvs.2023.11.002

Cited by 55 publications

(1 citation statement)

References 1,194 publications

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“…Abdominal aortic aneurysm is a serious cardiovascular disease that poses a serious risk to the patient's life. [29] It has a complex pathomechanism, but it is believed that the in ammatory response plays a key role. [10,30] In this study, we identi ed potential in ammatory biomarkers in patients with abdominal aortic aneurysms by Olink proteomics, aiming to provide directions for further research on abdominal aortic aneurysms as well as ideas for clinical diagnosis of the disease.…”

Section: Discussionmentioning

confidence: 99%

Olink Proteomics Platform Reveals Serum Inflammatory Related Protein Biomarkers in Abdominal Aortic Aneurysms

Zhang,

Chang,

Wang

et al. 2024

Preprint

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Abdominal aortic aneurysm is a cardiovascular disease associated with chronic inflammation that poses a serious threat to the population. This study used the emerging Olink proteomics technology with the aim of identifying markers associated with inflammation in the serum of patients with abdominal aortic aneurysm. Serum samples were collected from 14 patients with abdominal aortic aneurysms on the day of admission to the hospital and serum samples from 14 healthy individuals were used as controls. The expression levels of 92 inflammation-related proteins were compared between abdominal aortic aneurysm patients (n=8) and controls (n=8) using the Olink Proximity Extension Assay inflammation plate. Differential proteins were analyzed by enrichment analysis and ROC curve analysis to determine their role and value in the diagnosis and study of abdominal aortic aneurysms. Subsequently, five proteins were screened for ELISA validation by correlation analysis between differential proteins and the maximum diameter of abdominal aortic aneurysms in combination with expression differences and diagnostic value. The results of the study showed that 26 proteins were upregulated in expression in the abdominal aortic aneurysm group compared with the control group, and the selected FGF-19, CCL11, TNFRSF9, FGF-21, and IL-12B were validated by ELISA. The results showed that these five proteins were up-regulated in the serum of abdominal aortic aneurysm patients（P<0.05）, which may be novel diagnostic markers for abdominal aortic aneurysm disease.

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Section: Discussionmentioning

confidence: 99%