Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms

Wanhainen, Anders; Van Herzeele, Isabelle; Bastos Goncalves, Frederico; Bellmunt Montoya, Sergi; Berard, Xavier; Boyle, Jonathan R.; D’Oria, Mario; Prendes, Carlota F.; Karkos, Christos D.; Kazimierczak, Arkadiusz; Koelemay, Mark J.W.; Kölbel, Tilo; Mani, Kevin; Melissano, Germano; Powell, Janet T.; Trimarchi, Santi; Tsilimparis, Nikolaos; Antoniou, George A.; Björck, Martin; Coscas, Raphael; Dias, Nuno V.; Kolh, Philippe; Lepidi, Sandro; Mees, Barend M.E.; Resch, Timothy A.; Ricco, Jean Baptiste; Tulamo, Riikka; Twine, Christopher P.; Branzan, Daniela; Cheng, Stephen W.K.; Dalman, Ronald L.; Dick, Florian; Golledge, Jonathan; Haulon, Stephan; van Herwaarden, Joost A.; Ilic, Nikola S.; Jawien, Arkadiusz; Mastracci, Tara M.; Oderich, Gustavo S.; Verzini, Fabio; Yeung, Kak Khee

doi:10.1016/j.ejvs.2023.11.002

Cited by 140 publications

(28 citation statements)

References 1,194 publications

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“…Abdominal aortic aneurysm is a serious cardiovascular disease that poses a serious risk to the patient's life. [29] It has a complex pathomechanism, but it is believed that the in ammatory response plays a key role. [10,30] In this study, we identi ed potential in ammatory biomarkers in patients with abdominal aortic aneurysms by Olink proteomics, aiming to provide directions for further research on abdominal aortic aneurysms as well as ideas for clinical diagnosis of the disease.…”

Section: Discussionmentioning

confidence: 99%

Olink Proteomics Platform Reveals Serum Inflammatory Related Protein Biomarkers in Abdominal Aortic Aneurysms

Zhang,

Chang,

Wang

et al. 2024

Preprint

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Abdominal aortic aneurysm is a cardiovascular disease associated with chronic inflammation that poses a serious threat to the population. This study used the emerging Olink proteomics technology with the aim of identifying markers associated with inflammation in the serum of patients with abdominal aortic aneurysm. Serum samples were collected from 14 patients with abdominal aortic aneurysms on the day of admission to the hospital and serum samples from 14 healthy individuals were used as controls. The expression levels of 92 inflammation-related proteins were compared between abdominal aortic aneurysm patients (n=8) and controls (n=8) using the Olink Proximity Extension Assay inflammation plate. Differential proteins were analyzed by enrichment analysis and ROC curve analysis to determine their role and value in the diagnosis and study of abdominal aortic aneurysms. Subsequently, five proteins were screened for ELISA validation by correlation analysis between differential proteins and the maximum diameter of abdominal aortic aneurysms in combination with expression differences and diagnostic value. The results of the study showed that 26 proteins were upregulated in expression in the abdominal aortic aneurysm group compared with the control group, and the selected FGF-19, CCL11, TNFRSF9, FGF-21, and IL-12B were validated by ELISA. The results showed that these five proteins were up-regulated in the serum of abdominal aortic aneurysm patients（P<0.05）, which may be novel diagnostic markers for abdominal aortic aneurysm disease.

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Section: Discussionmentioning

confidence: 99%

Olink Proteomics Platform Reveals Serum Inflammatory Related Protein Biomarkers in Abdominal Aortic Aneurysms

Zhang,

Chang,

Wang

et al. 2024

Preprint

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“…Although the evidence for IMA and lumbar artery embolization in complex aortic repair is unclear, a recent meta-analysis of both prospective and retrospective studies suggests the benefit of occluding any patent IMA and ≥2 mm lumbar arteries to reduce the risk of endoleak in standard infrarenal repair [29], which can lead to overall instability of the endovascular reconstruction. Nevertheless, recent guidelines still do not endorse routine IMA and lumbar artery embolization for T2EL prevention [2] and highlight the higher benefits of IMA rather than lumbar embolization.…”

Section: Occlusion Of Aortic Side Branches For Endoleak Preventionmentioning

confidence: 99%

“…Embolization can be performed prior to graft deployment or in the same procedure with no clear differences between the two in terms of ischemic complications [49]. However, the most recent European Society for Vascular Surgery guidelines advise preservation of at least one patent IIA with a Class I recommendation [2].…”

Section: Internal Iliac Artery (Iia)mentioning

confidence: 99%

“…Endovascular repair of complex aortic aneurysms has gained popularity over the last decade due to comparable results with open surgery [1,2], the minor likelihood of complications, their cost-effectiveness [3,4], and their high feasibility [3]. With the rise of endovascular surgery, newer techniques of vessel embolization are being used by vascular specialists to occlude target vessels while treating the main aortic pathology.…”

Section: Introductionmentioning

confidence: 99%

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Plug-Based Embolization Techniques of Aortic Side Branches during Standard and Complex Endovascular Aortic Repair

Melloni,

D’Oria,

Dioni

et al. 2024

JCM

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Vascular plugs are an evolving family of vessel occluders providing a single-device embolization system for large, high-flow arteries. Nitinol mesh plugs and polytetrafluoroethylene membrane plugs are available in different configurations and sizes to occlude arteries from 3 to 20 mm in diameter. Possible applications during complex endovascular aortic procedures are aortic branch embolization to prevent endoleak or to gain an adequate landing zone, directional branch occlusion, and false lumen embolization in aortic dissection. Plugs are delivered through catheters or introducers, and their technical and clinical results are comparable to those of coil embolization. Plugs are more accurate than coils as repositionable devices, less prone to migration, and have fewer blooming artifacts on postoperative computed tomography imaging. Their main drawback is the need for larger delivery systems. This narrative review describes up-to-date techniques and technology for plug embolization in complex aortic repair.

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“…These predictive scores only included preoperative variables and presented several ceilings, thereby limiting their validation among the general population. Indeed, because of the low positive predictive value for death and major morbidity, both GAS and Hardman indices seem to be of limited value in clinical decision making, especially in high-risk patients [ 16 , 17 ]. Similarly, the RAA-POSSUM has fallen out of favor not only due to its calculation difficulty but also because it overestimates the number of patients at risk of death.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Predictors and Proposal for a Novel Prognostic Risk Score for In-Hospital Mortality after Open Repair of Ruptured Abdominal Aortic Aneurysms (SPARTAN Score)

Berchiolli,

Troisi,

Bertagna

et al. 2024

JCM

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(1) Background: Several mortality risk scores have been developed to predict mortality in ruptured abdominal aortic aneurysms (rAAAs), but none focused on intraoperative factors. The aim of this study is to identify intraoperative variables affecting in-hospital mortality after open repair and develop a novel prognostic risk score. (2) Methods: The analysis of a retrospectively maintained dataset identified patients who underwent open repair for rAAA from January 2007 to October 2023 in three Italian tertiary referral centers. Multinomial logistic regression was used to calculate the association between intraoperative variables and perioperative mortality. Independent intraoperative factors were used to create a prognostic score. (3) Results: In total, 316 patients with a mean age of 77.3 (SD ± 8.5) were included. In-hospital mortality rate was 30.7%. Hemoperitoneum (p < 0.001), suprarenal clamping (p = 0.001), and operation times of >240 min (p = 0.008) were negative predictors of perioperative mortality, while the patency of at least one hypogastric artery had a protective role (p = 0.008). Numerical values were assigned to each variable based on the respective odds ratio to create a risk stratification for in-hospital mortality. (4) Conclusions: rAAA represents a major cause of mortality. Intraoperative variables are essential to estimate patients’ risk in surgically treated patients. A prognostic risk score based on these factors alone may be useful to predict in-hospital mortality after open repair.

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Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms

Cited by 140 publications

References 1,194 publications

Olink Proteomics Platform Reveals Serum Inflammatory Related Protein Biomarkers in Abdominal Aortic Aneurysms

Olink Proteomics Platform Reveals Serum Inflammatory Related Protein Biomarkers in Abdominal Aortic Aneurysms

Plug-Based Embolization Techniques of Aortic Side Branches during Standard and Complex Endovascular Aortic Repair

Intraoperative Predictors and Proposal for a Novel Prognostic Risk Score for In-Hospital Mortality after Open Repair of Ruptured Abdominal Aortic Aneurysms (SPARTAN Score)

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