Abstract-The animation practical teaching system was designed by using multimedia interaction technology of converting pictures into animation and incorporating them into videos. Besides, teaching effect of the system was analyzed based on findings of an experiment and a questionnaire. As shown in the analysis result, the multimedia interaction teaching system, which has attained a good effect in practical teaching for the animation major, is very popular among students. In addition, the system enhances students' learning interest and efficiency through an intelligent way, helps students get rid of the space-time restriction and reinforce their capacity of independent learning. Generally, this paper aims to improve the effect of practice teaching for the animation major.