Edible Rabies Vaccines

Loza-Rubio, Elizabeth; Rojas-Anaya, Edith

doi:10.1007/978-3-662-43836-7_9

Cited by 2 publications

(1 citation statement)

References 82 publications

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“…There are numerous examples of candidate vaccines based on the G protein or nucleoprotein produced in plants. Many review articles discuss the progress in the development of plant-based vaccines against RABV [13,116,289,290]. Transgenic tobacco plants have been modeled to produce rabies G protein at 0.38% of the total soluble leaf protein, which, upon purification and immunization, provided complete protection in mice after a lethal challenge [291].…”

Section: Rabdoviruses Rabies Virus (Rabv)mentioning

confidence: 99%

Plant-Derived Recombinant Vaccines against Zoonotic Viruses

Zahmanova

Takova

Valkova

et al. 2022

Life

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Emerging and re-emerging zoonotic diseases cause serious illness with billions of cases, and millions of deaths. The most effective way to restrict the spread of zoonotic viruses among humans and animals and prevent disease is vaccination. Recombinant proteins produced in plants offer an alternative approach for the development of safe, effective, inexpensive candidate vaccines. Current strategies are focused on the production of highly immunogenic structural proteins, which mimic the organizations of the native virion but lack the viral genetic material. These include chimeric viral peptides, subunit virus proteins, and virus-like particles (VLPs). The latter, with their ability to self-assemble and thus resemble the form of virus particles, are gaining traction among plant-based candidate vaccines against many infectious diseases. In this review, we summarized the main zoonotic diseases and followed the progress in using plant expression systems for the production of recombinant proteins and VLPs used in the development of plant-based vaccines against zoonotic viruses.

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