Edible Bird’s nest extract as a chondro-protective agent for human chondrocytes isolated from osteoarthritic knee: in vitro study

Chua, Kien Hui; Lee, Ting Hun; Nagandran, Kamini; Yahaya, N H M; Lee, Chew Tin; Tan, Eddie Ti Tjih; Aziz, Ramlan Abdul

doi:10.1186/1472-6882-13-19

Cited by 55 publications

(32 citation statements)

References 30 publications

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“…This obviously requires replication. An extract of edible bird's nest (which is made from swiftlet saliva), has been shown to have anti-catabolic, anti-inflammatory and pro-anabolic activity on human osteoarthritic chondrocytes (166) . Sesamin, a lignan from sesame seeds has been reported to be chondroprotective in an explant assay, decreasing MMP expression and activation (167) .…”

Section: Othersmentioning

confidence: 99%

The potential for dietary factors to prevent or treat osteoarthritis

et al. 2014

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Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this disease will increase in the future. Focusing on compounds from the habitual diet that may prevent the onset or slow the progression of OA is a strategy that has been under-investigated to date. An approach that relies on dietary modification is clearly attractive in terms of risk/benefit and more likely to be implementable at the population level. However, before undertaking a full clinical trial to examine potential efficacy, detailed molecular studies are required in order to optimise the design. This review focuses on potential dietary factors that may reduce the risk or progression of OA, including micronutrients, fatty acids, flavonoids and other phytochemicals. It therefore ignores data coming from classical inflammatory arthritides and nutraceuticals such as glucosamine and chondroitin. In conclusion, diet offers a route by which the health of the joint can be protected and OA incidence or progression decreased. In a chronic disease, with risk factors increasing in the population and with no pharmaceutical cure, an understanding of this will be crucial.Osteoarthritis: Diet: Cartilage: Bioactive: Polyphenol: Phytochemical: Flavonoid Osteoarthritis (OA) is a degenerative joint disease characterised by degradation of articular cartilage, thickening of subchondral bone and osteophyte formation. Incidence and prevalence of OA has been difficult to assess, in part because of heterogeneity in definitions of the disease. A recent meta-analysis suggested that overall prevalence of OA at different anatomical sites was 23·9 % (knee), 10·9 % (hip) and 43·3 % (hand), although only the prevalence of knee OA showed a gender difference between women and men (27·3 and 21 %, respectively)(1) . Osteoarthritis is a leading cause of disability in the UK. A recent survey (2) found 8·5 million people in the UK with OA, with 71 % of these in constant pain. There are no effective disease-modifying drugs to treat OA and drugs that relieve pain are often insufficient. Joint replacement is offered to patients at end-stage disease with 66 436 hip and 77 578 knee replacements due to OA performed in the UK in 2011 (3) . Two major risk factors for OA are increasing age (most affected patients are aged >45 years and the greatest morbidity is seen in patients aged >60 years) (4) and increasing obesity (5) . With changing demographics, OA is an increasing public health and economic burden. The economic costs of OA in the UK are largely unknown, but direct costs have been estimated at approximately £1 billion/year. With inclusion of indirect costs, estimates from the USA range up to £8 billion/ year (6) .*Corresponding author: I. M. Clark, fax 01603-592250, email i.clark@uea.ac.uk †These authors contributed equally to this review.Abbreviations: ADAMTS, a disintegrin and metalloproteina...

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Section: Othersmentioning

confidence: 99%

The potential for dietary factors to prevent or treat osteoarthritis

et al. 2014

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“…On top of that, investigation of EBN as a chondro-protective agent was carried out in vitro by using human articular chondrocytes that were isolated from knee joint of patients with osteoarthritis [18] . The addition of EBN to the cell cultures slows the progression of osteoarthritis and aided in the regeneration of cartilage.…”

Section: Effects Of Ebn On Bone Regenerationmentioning

confidence: 99%

A Mini Review on Medicinal Effects of Edible Bird’s Nest

Chye¹,

Tai²,

Koh³

et al. 2017

LHBS

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Edible bird's nest is a famous and nutritious food which is well-known among Chinese community. It is made from the saliva of swiftlets. It is consumed for various reasons, including as health tonic, complexion enhancer, asthma alleviator and immune system enhancer. It contains both macronutrients and micronutirents such as carbohydrates, glycoproteins, calcium, sodium, magnesium, zinc, manganese, iron and others. To date, a number of studies have reported on the health benefits of EBN consumption. Hence, this review describes the various medicinal values of EBN.

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“…Edible bird's nest (EBN) is one of the famous Chinese traditional medicines that are reported to have high nutritional and medicinal values (Chua, Lee, Nagandran, & Yahaya, 2013;Guo et al, 2006;Kim et al, 2012;Marcone, 2005;Goh et al, 2001;Vimala, Hussain, & Nazaimoon, 2012). It is made from saliva of male Collocalia swiftlets that found in the Southeast Asian regions (Malaysia, Indonesia and Thailand).…”

Section: Introductionmentioning

confidence: 97%

Determination of porcine gelatin in edible bird's nest by competitive indirect ELISA based on anti-peptide polyclonal antibody

et al. 2016

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a b s t r a c tCompetitive indirect enzyme-linked immunosorbent assay (ELISA) was developed for rapid detection of porcine gelatin in edible bird's nest (EBN). Three ELISAs were developed by using polyclonal rabbit antibodies against porcine species-specific amino acid sequences of collagen a2 (I) chain (pAb1 and pAb2) and a1 (I) chain (pAb3). The limit of detection (IC 15 ) of the three ELISAs was 0.033, 0.082 and 0.052 mg/mL respectively. The median inhibitory concentration (IC 50 ) of pAb1, pAb2 and pAb3 was 0.265, 0.394 and 0.228 mg/mL respectively, as well as able to recognise porcine and bovine gelatins. pAb1showed slight cross-reactivity with cave nest and egg white, while pAb2 exhibited slight cross-reactivity with blood cave nest and egg white. No cross-reactivity was observed with EBNs and egg white for pAb3. The recoveries of porcine gelatin spiked EBNs were in the range of 62.8e125.4% with intra-and inter-day coefficient of variants (CVs) of 2.9e5.4% and 4.7e9.6% respectively when using pAb3. Taking into account all abovementioned factors, pAb3 appeared sufficient for EBN authentication.

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Edible Bird’s nest extract as a chondro-protective agent for human chondrocytes isolated from osteoarthritic knee: in vitro study

Cited by 55 publications

References 30 publications

The potential for dietary factors to prevent or treat osteoarthritis

The potential for dietary factors to prevent or treat osteoarthritis

A Mini Review on Medicinal Effects of Edible Bird’s Nest

Determination of porcine gelatin in edible bird's nest by competitive indirect ELISA based on anti-peptide polyclonal antibody

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