In medical ionography an electrostatic latent image of the object is formed by collecting on an insulating sheet the ions formed in a layer of compressed gas or of insulating liquid. This latent image can then be rendered visible by powder cloud development. In order to reduce the radiation exposure to the patient it is desirable to improve the sensitivity of this development. In ionographic autoradiography the sensitivity of powder cloud development has been increased by using thicker dielectric layers instead of the 50 mu m foils normally used. The use of thicker sheets in medical ionography, however, resulted in a severe loss of detail. The contrast is reduced with increasing layer thickness for non-repetitive patterns typical of medical images. Contrast may be regained for a repetitive pattern. From these findings it may be concluded: (a) that an increased sensitivity in medical ionography is not feasible by powder cloud development on thick dielectric layers, and (b) that resolution measurements with a repetitive pattern need to be evaluated very carefully in this case.