Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac

Abstract

Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.

Optimization of Soya Phosphatidylcholine and Tween 80 As A Preparation of Diclofenac Sodium Transfersome Vesicles Using Design-Expert

“…Transfersome suspension is placed on the surface of the slide. The shape and size of the vesicles were observed using an optical microscope with a magnification of 100 times (Dalimunthe and Ricky, 2021).…”

“…This extensive metabolism is the reason why DS has poor oral bioavailability (Yuan et al, 2017). Oral administration of diclofenac sodium can also cause gastrointestinal and cardiovascular side effects (Dalimunthe and Ricky, 2021). Therefore, the transdermal delivery system was chosen as an alternative to overcome these problems.…”

“…The composition of phosphatidylcholine as a phospholipid and tween 80 as a surfactant is a variable that can affect the optimization of the transfersome formula. Therefore, the ratio of phospholipids and surfactants should be varied to obtain the most stable transfersome formula with high drug entrapment efficiency (Nurmahliati et al, 2020;Sari et al, 2020;Dalimunthe and Ricky, 2021). Optimization as an approach to get the best combination of a formula can be done in a more efficient way using software called Design-Expert.…”

Optimasi Fosfatidilkolin dan Span 80 sebagai Penyusun Vesikel Transfersom Natrium Diklofenak menggunakan Design-Expert

“…Aktivator tepi adalah komponen pelembut bilayer, seperti surfaktan biokompatibel yang berfungsi meningkatkan fleksibilitas dan permeabilitas bilayer lipid. Konsentrasi span 80 yang terlalu tinggi dapat menyebabkan transfersom kehilangan struktur vesikelnya karena pembentukan misel yang berlebihan [14]. Peningkatan jumlah surfaktan dapat membentuk dispersi transfersom dengan ukuran partikel yang lebih besar.…”

Production of Antioxidant Transfersomes by a Supercritical CO2 Assisted Process for Transdermal Delivery Applications

“…The optimal formulation produced vesicles of about 116 nm with an encapsulation efficiency of around 94%, but ζ-potential was 11 mV. Dalimunthe et al [ 9 ] prepared transfersomes loaded with diclofenac using the vortex-sonication method. Formulations prepared using phosphatidylcholine and Tween80 at an 85:15 ratio produced transfersomes with the highest encapsulation efficiency (94%), but they were characterized by a mean diameter of 617 nm.…”