Edema in Renal Diseases – Current View on Pathogenesis

Bobkova, Irina; Chebotareva, Natalia; Kozlovskaya, L V; Шилов, Е.М.

doi:10.5301/pocj.5000204

Cited by 18 publications

(19 citation statements)

References 46 publications

(42 reference statements)

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“…Therefore, reducing both level will be ameliorate the kidney's function. 39 , 40 In our study, EEBS treatment had improved physiological condition as marked by lower BUN and UA level. The BUN and UA level lowered significantly compared to positive control (p < 0.05).…”

Section: Resultssupporting

confidence: 59%

Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential

Widowati

Prahastuti

Hidayat

et al. 2022

Journal of Traditional and Complementary Medicine

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Section: Resultssupporting

confidence: 59%

Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential

Widowati

Prahastuti

Hidayat

et al. 2022

Journal of Traditional and Complementary Medicine

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“…The significance of damage to podocytes and swelling of the kidneys as a universal mechanism of development of renal failure [3] has been confirmed today. The relevance of the study of the dependence of the renal function on its size is established [9].…”

Section: Discussionmentioning

confidence: 95%

Changes in the sizes of the kidney after contralateral nephrectomy in the experiment

Моnastyrskyi

2018

Rep. of Morph.

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The evaluation of renal measurements such as length, width and thickness, volume is important in the diagnosis and treatment of many renal disorders, since there is a close relationship between the sizes of the kidneys and its function. The purpose of the study was to establish and compare during the postoperative period changes in the mass and sizes of the kidney left after nephrectomy in the sexually mature male rats. An experimental study was carried out on 84 sexually mature white male rats weighing 178-194 grams. Animals were divided into two groups: control (42 rats) and experimental (42 rats). In the control group, the animals under ketamine anesthesia were followed by an abdominal cavity dilution, after which the abdominal wall was applied in a row. All animals of the experimental group performed surgical intervention – nephrectomy of the left kidney. The animals were withdrawn from the trial by intra-pleural administration of thiopental-sodium 50 mg/kg after 7, 14, 21, 30, 90 days after nephrectomy. Macroscopic evaluation and description of the kidneys of animals was performed after their removal. Their weight was determined on the laboratory scale of HLR-200 up to 0.1 mg, and the length, width and thickness of the organ were measured with the help of a caliper to an accuracy of 0.05 mm. Calculated the volume of the kidney. The statistical analysis of the obtained results was carried out using the program STATISTICA 5.5 using parametric methods for evaluating the results. It was established that the mass, length, width, thickness and volume of the kidney of animals in the experimental group, as compared with the control group, were statistically significantly higher in all terms of observation. The fraction of the growth of the width and thickness of the single kidney of animals in the experimental group compared with the control animals in the animals was statistically significantly greater than the proportion of kidney growth during the postoperative period. It was found that the largest increase in the mass and thickness of the kidney, as compared with the control group, was observed after 30 days of the postoperative period, and the greatest increase in the length and width of the kidney, as compared with the control group, was observed after 14 days of the postoperative period.

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“…Patients with low albumin will lose colloidal osmotic (oncotic) pressure, and experience an extracellular uid shift from the intravascular space into the extravascular space (Gounden, Vashisht, and Jialal 2020). Notably, hypoalbuminemia coupled with excess extracellular uid may result in co-occurring oedema and hypovolemia (Bobkova et al 2016). Such a mechanism has also been suggested to contribute to COVID-19 (J.…”

Section: Discussionmentioning

confidence: 99%

Fluid, pH and electrolyte imbalance associated with COVID-19 mortality

Nahkuri

Becker

Schueller

et al. 2021

Preprint

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The threat of COVID-19 has harried the world since early 2020. Risk of death from the infection is associated with age and pre-existing comorbidities such as diabetes, dementia, cancer, and impairment of immunological, hepatic or renal function. It still remains incompletely understood why some patients survive the disease, while others perish. Our univariate and multivariate analyses of real world data from U.S. electronic health records indicate that a priori diagnoses of fluid, pH and electrolyte imbalance are highly and independently associated with COVID-19 mortality. We propose that pre-existing homeostatic aberrations are magnified upon the loss of ACE2, which is a core component of the electrolyte management system as well as the entry point of internalizing SARS-CoV-2 viruses. Moreover, we also suggest such fragility of electrolyte homeostasis may increase the risk of plasma volume disturbances during the infection. Future interventional studies should investigate whether the risk of death can be alleviated by personalized management of the fluid and electrolyte balance of at-risk individuals before and during COVID-19.

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Edema in Renal Diseases – Current View on Pathogenesis

Cited by 18 publications

References 46 publications

Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential

Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential

Changes in the sizes of the kidney after contralateral nephrectomy in the experiment

Fluid, pH and electrolyte imbalance associated with COVID-19 mortality

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