Edema associated with I-125 or Pd-103 prostate brachytherapy and its impact on post-implant dosimetry: an analysis based on serial CT acquisition

Waterman, Frank M.; Yue, Ning J.; Corn, Benjamin W.; Dicker, Adam P.

doi:10.1016/s0360-3016(98)00152-7

Cited by 211 publications

(170 citation statements)

References 9 publications

Supporting

Mentioning

161

Contrasting

Order By: Relevance

“…[56][57][58] Furthermore, postimplant edema can further reduce the dose delivered by the implant. [59][60][61] Hence it cannot be assumed that the patient would receive the dose prescribed in the pretreatment dosimetric plan.…”

Section: Rationalementioning

confidence: 99%

Permanent prostate seed implant brachytherapy: Report of the American Association of Physicists in Medicine Task Group No. 64

et al. 1999

Self Cite

View full text Add to dashboard Cite

There is now considerable evidence to suggest that technical innovations, 3D image-based planning, template guidance, computerized dosimetry analysis and improved quality assurance practice have converged in synergy in modern prostate brachytherapy, which promise to lead to increased tumor control and decreased toxicity. A substantial part of the medical physicist's contribution to this multi-disciplinary modality has a direct impact on the factors that may singly or jointly determine the treatment outcome. It is therefore of paramount importance for the medical physics community to establish a uniform standard of practice for prostate brachytherapy physics, so that the therapeutic potential of the modality can be maximally and consistently realized in the wider healthcare community. A recent survey in the U.S. for prostate brachytherapy revealed alarming variance in the pattern of practice in physics and dosimetry, particularly in regard to dose calculation, seed assay and time/method of postimplant imaging. Because of the large number of start-up programs at this time, it is essential that the roles and responsibilities of the medical physicist be clearly defined, consistent with the pivotal nature of the clinical physics component in assuring the ultimate success of prostate brachytherapy. It was against this background that the Radiation Therapy Committee of the American Association of Physicists in Medicine formed Task Group No. 64, which was charged ͑1͒ to review the current techniques in prostate seed implant brachytherapy, ͑2͒ to summarize the present knowledge in treatment planning, dose specification and reporting, ͑3͒ to recommend practical guidelines for the clinical medical physicist, and ͑4͒ to identify issues for future investigation.

show abstract

Section: Rationalementioning

confidence: 99%

Permanent prostate seed implant brachytherapy: Report of the American Association of Physicists in Medicine Task Group No. 64

et al. 1999

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ideally, this clarity of the prostate volume could be combined with the clarity of seed definition by CT to allow improved postimplant dosimetry. Another reason for CT-imaging is assessment of edema associated with 125 I or 103 Pd prostate brachytherapy and its impact on post-implant dosimetry (Waterman et al, 1998). Pelvic CT scanning is used to determine the necessity of preoperative evaluation of pubic arch interference in patients with small prostate volumes.…”

Section: Prostate Cancermentioning

confidence: 99%

CT-Image Guided Brachytherapy

Skowronek¹

2011

Theory and Applications of CT Imaging and Analysis

View full text Add to dashboard Cite

“…When the implanted sources are assumed to follow the movement of its surrounding tissue without relative migration and the edema is spatially isotropic, Eq. (3) implies that (4) where r Pi (0) the distance before the onset of edema. To make the time integration in Eq.…”

Section: B Edema-induced Dose Reductionmentioning

confidence: 99%

On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy

Chen

Deng

Roberts

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Purpose-Surgical-trauma-induced edema and its protracted resolution can lead to significant dose reduction in pre-planned 131 Cs prostate brachytherapy. The purpose of this work was to examine whether these dose reductions should be actively compensated and to estimate the magnitude of additional irradiations needed for dose compensation.Methods and Materials-Quantitative edema resolution characteristics observed by Waterman et. el. were used to examine the physical and radiobiological effects of prostate edema in preplanned 131 Cs implants. The need for dose compensation was assessed based on the dose-responses observed in 125 I and 103 Pd prostate implants. Biologically effective dose calculated with full consideration of edema evolution was used to estimate the additional irradiations needed for dose compensation.Results-Edema-induced dose reduction in pre-planned 131 Cs implants could easily exceed 10% prescription dose for implants with moderate or large edemas. These dose reductions could lead to more than 10% reduction in biochemical recurrence-free survival for individual patients if the effect of edema was ignored. For a prescribed dose of 120 Gy, the number of 2-Gy external-beam fractions needed to compensate a 5%, 10%, 15%, 20%, or 25% edema-induced dose reduction could be 1, 4, 6, 7, or 9, respectively, for prostate cancers with a median potential doubling time of 42 days. The required additional irradiation increases for tumors that are fast growing and/or are less efficient in sub-lethal damage repair.Conclusions-Compensation of edema-induced dose reductions in pre-planned 131 Cs prostate brachytherapy should be actively considered for those implants with moderate or large edemas.

show abstract

Edema associated with I-125 or Pd-103 prostate brachytherapy and its impact on post-implant dosimetry: an analysis based on serial CT acquisition

Cited by 211 publications

References 9 publications

Permanent prostate seed implant brachytherapy: Report of the American Association of Physicists in Medicine Task Group No. 64

Permanent prostate seed implant brachytherapy: Report of the American Association of Physicists in Medicine Task Group No. 64

CT-Image Guided Brachytherapy

On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy

Contact Info

Product

Resources

About