Edaravone, a Free Radical Scavenger, Improves the Graft Viability on Liver Transplantation From Non–heart-beating Donors in Pigs

Miyazawa, Kohtaro; Miyagi, Shigehito; Maida, Kai; Murakami, Kensuke; Fujio, Atsushi; Kashiwadate, Toshiaki; Nakanishi, Waka; Hara, Yasuyuki; Nakanishi, Chikashi; Yamaya, Hidetoshi; Kawagishi, Naoki; Goto, Masafumi; Ohuchi, Noriaki

doi:10.1016/j.transproceed.2013.11.155

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Cited by 9 publications

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“…Edaravone possesses beneficial free radical scavenging and antioxidant characteristics . Accordingly, studies in various animal models have reported the protective effects of edaravone in the context of ischemia–reperfusion injuries in transplanted livers , kidneys , lungs , and pancreatic islet tissues .…”

Section: Discussionmentioning

confidence: 99%

“…Edaravone possesses beneficial free radical scavenging and antioxidant characteristics [19,20]. Accordingly, studies in various animal models have reported the protective effects of edaravone in the context of ischemia-reperfusion injuries in transplanted livers [12,21,26], kidneys [14,22,23], lungs [24], and pancreatic islet tissues [17]. While our study involved intrasplenic HTx, hepatocytes can be transplanted either intraportally or intrasplenically to obtain transplanted cells in the liver [25].…”

Section: Discussionmentioning

confidence: 99%

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