ED identification of patients with severe sepsis/septic shock decreases mortality in a community hospital

The MISSED score, a new scoring system to predict Mortality In Severe Sepsis in the Emergency Department

“…There was no significant difference in mortality rates between the two The MISSED score: a new sepsis score Sivayoham et al 33 groups (P = 0.46). The median APACHE II score was 14 (IQR [10][11][12][13][14][15][16][17][18][19]. The distribution of the source of sepsis was similar to that in the derivation data and described in Fig.…”

“…Two of the 26 are known to have died. The remaining 641 patients had an APACHE II score of 16 [interquartile range (IQR) [10][11][12][13][14][15][16][17][18][19][20][21], mortality rate of 30.1% (193 deaths). The 641 patients were placed in chronological order; the first 320 forming the derivation study population and the remaining 321 forming the validation study population ( Fig.…”

“…Ideally, those satisfying any of the criteria defining severe sepsis should receive aggressive resuscitation in the ED. Whilst aggressive resuscitation, such as implementing EGDT in the ED may be beneficial to patients by reducing mortality and reducing length of stay [9,11], it is also invasive and labour intensive in the ED. It must, therefore, be focused on those patients who would benefit the most.…”

A quality improvement project to improve early sepsis care in the emergency department

“…While earlier sepsis recognition and management has been shown to reduce the need for the downstream elements of early goal-directed therapy,6 10 few protocols targeting improved sepsis screening have been reported. In one study, a protocol incorporating screening by triage nurses led to an improvement in SSC element compliance 11.…”

A Dual-Coreactants Electrochemiluminescent Immunosensor for Procalcitonin Detection Based on CdS-MoS2Nanocomposites

“…1 Early diagnosis of septicemia and timely initiation of evidence-based treatment strategies are known to improve the clinical outcomes and to reduce septicemia-related mortality. 2 Procalcitonin (PCT) produced by C-cells of the thyroid gland, could be used a biomarker for early diagnosis of septicemia. The physiological values are less than 0.1 ng mL −1 in normal human, and rise with the deterioration of sepsis.…”