Eczematous Contact-Sensitivity to Gold

Fox, Jack

doi:10.1001/archderm.1961.01580120068016

Cited by 36 publications

(4 citation statements)

References 5 publications

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“…Ten patients had oral lesions related, at least in part, to gold dental restorations ( Table 1). Replacement of these was performed in six patients (nos 4,7,8,18,30,31). No resolution was seen, after a follow-up of 6-12 months, in patients 4, 7, 8 and 18.…”

Section: Clinical and Histological Findingsmentioning

confidence: 96%

Contact allergy to gold in dental patients

Räsänen

Kalimo

Laine

et al. 1996

British Journal of Dermatology

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Gold sodium thiosulphate (GSTS) in patch test series commonly yields positive reactions. In this study of dental patients, the clinical relevance of these positive reactions, the suitability of gold compounds as patch test materials, and value of the lymphocyte proliferation test in gold contact allergy, were evaluated. The frequency of positive patch test reactions to GSTS was 12.4% in the dental series. Fifty-two patients, only two of whom were male, were studied. Thirteen (25%) had had symptoms from jewellery or dental restorations. However, in most cases gold allergy was subclinical. A 10% aqueous solution of gold sodium thiomalate (GSTM) was almost as good as 0.5% GSTS in petrolatum as a marker of gold contact allergy, but 0.001% potassium dicyanoaurate (PDCA) yielded a high percentage of false-negative results. Seventy-three per cent of the subjects with positive patch tests to GSTS responded to gold compounds in vitro in the lymphocyte proliferation test, whereas 13 controls without gold contact sensitivity were negative. Consistent results in skin and lymphocyte proliferation tests provide support for the concept that gold salt-induced 'allergic-like' reactions are truly allergic in nature.

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Section: Clinical and Histological Findingsmentioning

confidence: 96%

Contact allergy to gold in dental patients

Räsänen

Kalimo

Laine

et al. 1996

British Journal of Dermatology

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“…Gold patch test reactions are often delayed in appearance until after day 3 and may take weeks to months to resolve; these are atypical responses more suggestive of allergy than irritancy. Gold is a common cause of irrelevant positive patch tests [26•], although definite gold jewelry [27][28][29], occupational [30], and oral gold reactions [31] have been reported. Avoidance of gold jewelry is reported to occasionally clear dermatitis at ectopic sites [32].…”

Section: Metal Allergy In Atopic Dermatitismentioning

confidence: 99%

The role of patch testing for chemical and protein allergens in atopic dermatitis

Nedorost

Cooper

2001

Curr Allergy Asthma Rep

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Many patients who present for evaluation of allergic contact dermatitis have an atopic diathesis. Although the immunologic basis of atopic dermatitis differs from that of allergic contact dermatitis--and patients with atopic dermatitis are less easily sensitized under experimental conditions--atopic patients do develop allergic contact dermatitis, and patch testing is a valuable part of their medical care. Delayed (7-day) patch test readings are especially important in atopic patients to distinguish allergy from irritancy and to evaluate for steroid allergy. The utility of atopy patch tests to aeroallergens such as dust mite is increasingly recognized; aeroallergens may be the cause of a type of protein contact dermatitis.

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“…Allergic contact dermatitis and stomatitis from gold have occasionally been reported (12)(13)(14)(15)(16)(17)(18)(19)(20)(21). The allergy has been demonstrated by patch testing with various gold salts (12)(13)(14)(15)(16)(17)(18)(19)(20)(21) and even with the metal itself (12).…”

mentioning

confidence: 99%

“…The allergy has been demonstrated by patch testing with various gold salts (12)(13)(14)(15)(16)(17)(18)(19)(20)(21) and even with the metal itself (12). In the 1960s, Kligman found gold chloride to be a strong sensitizer in a human maximization test (22).…”

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confidence: 99%

Gold – a controversial sensitizer

Bruze

Andersen

1999

Contact Dermatitis

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Until recently, gold allergy was considered to be extremely rare. Gold has been used and worshipped for thousands of years without any obvious complaints of skin problems, either in those participating in mining and other ways of prospecting, or in those wearing jewellery. When studies on contact allergy to gold sodium thiosulfate were published at the beginning of the 1990s, the allergic nature of the reported positive patch test reactions to gold was questioned. The major argument for such questioning was the lack of demonstrable clinical relevance in most positive reactors. A major reason for the questioning may have been confusion in differentiating between contact allergy and allergic contact dermatitis. To arrive at a diagnosis of allergic contact dermatitis, 3 steps have, in principle, to be fulfilled: (i) establishment of contact allergy; (ii) demonstration of present exposure; (iii) assessment of clinical relevance, i.e., causing or aggravating a contact dermatitis. In this paper, these steps are discussed with regard to gold. With our present knowledge of contact allergy -allergic contact dermatitis, we do not recommend including gold sodium thiosulfate in the standard series. It should be applied for scientific purposes and when allergic contact dermatitis from gold is suspected.

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Eczematous Contact-Sensitivity to Gold

Cited by 36 publications

References 5 publications

Contact allergy to gold in dental patients

Contact allergy to gold in dental patients

The role of patch testing for chemical and protein allergens in atopic dermatitis

Gold – a controversial sensitizer

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