ECZEMATOUS ALLERGY TO METALS<sup>1</sup>

Marcussen, Poul V.

doi:10.1111/j.1398-9995.1962.tb02959.x

Cited by 20 publications

(4 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with this view, mixtures of bovine serum albumin with monobenzylpenicilloyl-heptalysine (which would not be expected to form as much as five such bonds per mole) did not induce benzylpenicilloyl-specific antibodies in nonresponder guinea pigs (16). Finally, the known immuno genicity of metal ions such as chromium, nickle, and cobalt (17) would sug gest that in these cases coordinate covalent bonds may provide high binding energies. By contrast, the drug-protein complexes formed by the "reversible" binding of many drugs to serum albumin are held together by comparatively weak forces, such as provided by ionic and Van der Waals bonds.…”

Section: Levinementioning

confidence: 97%

Immunochemical Mechanisms of Drug Allergy

Levine¹

1966

Annu. Rev. Med.

View full text Add to dashboard Cite

Section: Levinementioning

confidence: 97%

Immunochemical Mechanisms of Drug Allergy

Levine¹

1966

Annu. Rev. Med.

View full text Add to dashboard Cite

“…Due to a low excretion rate, cadmium is accumulated in the human organism, and the primary target organs are kidney cortex and liver, and to some degree also lung and bone tissue. However, little is known about its importance as a skin sensitizer, and most studies based upon routine patch testing have demonstrated a low frequency of positive reactions (4)(5)(6). A widespread but rather.…”

mentioning

confidence: 99%

The role of cadmium as a skin sensitizing agent in denture and non‐denture wearers

Kaaber¹,

Cramers

Jepsen

1982

Contact Dermatitis

View full text Add to dashboard Cite

Positive patch test reactions to cadmium were observed in 8 out of 21 denture wearing persons with burning mouth sensations during 1979 and 1980, and in 13 of 125 consecutive outpatients being routine tested at the Dermatological Department in late 1980 and early 1981. Retesting 17 of these patients after at least 3 months delay with 2.0% cadmium chloride and 2% cadmium sulphate in water showed only 7 with a definite positive reaction. At serial dilution of cadmium sulphate, only 1 person reacted to a 1% aqueous solution. An exposure to cadmium could in 1 case be traced back to a 2-year period of work in a PVC plant, while in the remaining 6 cases the most probable exposure factor seemed to be chronic heavy cigarette smoking. The observations did not lend support to the pink acrylic denture base material being a relevant cadmium exposure factor.

show abstract

“…S im u ltan eo u sly , p o sitive C rv i a n d Co reactio n s h a v e b een fo u n d m ost often in p a tie n ts w ith cem e n t eczem a, b u t th e p o s itiv ity o f th e derm al te st for Co is n o t u n co m m o n in N i-sen sitizatio n , e ith e r. Storck an d Schwarz [10] h av e trie d to ex p lain th e problem on th e basis of th e place o f m etals in A n tro p o ff's periodic sy stem . M arcussen [9,10] has suggested th a t b ein g in such a close v icin ity to each o th e r in th e periodic sy stem Co a n d N i a re c o n ta m in a te d b y each o th e r and has proved th is by a n a ly tic a l stu d ies. In sp ite o f th is, p a tie n ts w ith cem en t eczem a often show p o sitiv e reactio n to Co to g e th e r w ith th a t to C rvi, w hereas a jo in t p o sitiv ity w ith N i occurs seldom , alth o u g h on th e basis o f th e ir close chem ical realtio n sh ip we o u g h t to get a closely sim ilar v alu e.…”

mentioning

confidence: 99%