Eczema Vaccinatum and Eczema Herpeticum in Darier Disease

Darier’s disease complicated by Kaposi’s varicelliform eruption due to herpes simplex virus

“…KVE is defined as an uncommon viral infection caused by herpes simplex, vaccinia or coxsackie virus 3–5 that occurs in various skin diseases, such as atopic dermatitis, Wiskott–Aldrich syndrome, pemphigus foliaceus, ichthyosis vulgaris, bullous pemphigoid, seborrhoeic dermatitis and Darier’s disease. 2,3–6 Mycosis fungoides, burns, traumatic facial abrasions and autologous skin grafting may very rarely be complicated by KVE.…”

“…However, no specific abnormality in immune function has been demonstrated to date. 3–7 The role of a defective skin barrier acting in conjunction with these immune defects is supported by the fact that viral lesions tend to develop first on previously abnormal skin. 10 …”

A Seroepidemiological Study of Herpes Simplex Virus

“…It is important in this connection that herpetic infection dose not result in milder diseases in adults than in children but does sometimes cause serious diseases such as encephalitis (Zarafonetis et al ., 1944;Leider et al, 1965;Overgaard, Hvid-Hansen and Laursen , 1971), generalization (Soltz-Szots and Fanta, 1971) or Kaposi's varicelliform eruption (Carney et al ., 1973), sometimes of a recurrent form (Boake, 1951;Mailman, Miranda and Spock , 1964). In fact, recent reports on the incidence of herpetic encephalitis (Miller and Ross , 1968;Rappel, 1972;Ross, 1972;Sarubbi et al, 1973), herpetic whitlow (Brightman and Guggenheimer , 1970 ;Orkin, 1970;Juel-Jensen, 1971;LaRossa and Hamilton, 1971), skin infection among wrestlers (Dyke et al, 1965;Porter and Baughman , 1965;Wheeler and Cabaniss, 1965), adult stomatitis (Davies andLongson , 1970), upper (Sheridan andHermann, 1971) and lower respiratory infections (Douglas et al ., 1969;Nash and Foley , 1970 ;Nash, 1972) and genital herpes (Ng, Reagan and Yen, 1970;Potts, 1970;Wolinska and Melamed, 1970) all indicate that adults are now becoming new targets for herpetic infection.…”

Traitement par acyclovir d’un eczema herpeticum compliquant une maladie de Darier

“…Tandis que l'atopique risque de faire un eczema herpeticum entre 5 et 18 mois, le pa tient atteint de maladie de Darier est exposé à cette complication beaucoup plus tardive ment; la dermatose évolue quelquefois de puis plus de 20 ans [2,[7][8][9][10]14] lorsque sur vient cette surinfection virale, d'autant moins prévisible que certains de ces sujets ont été vaccinés contre la variole, ont fait une varicelle sans complications [2,8] et mê me une primo-infection herpétique asymp tomatique comme le prouve la présence d'anticorps [4].…”