Eczema herpeticum in Darier's disease: a topical storm

Tayabali, Khadija; Pothiwalla, Hussein; Lowitt, Mark H.

doi:10.1080/20009666.2019.1650590

Cited by 10 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The remaining 10 patients could have SERCA2 levels that can cause the disease but are adequate for normal B cell development. Darier disease patients are prone to skin infections, likely due to disrupted skin integrity, but could also be impacted by concomitant immune dysfunction ( Tayabali et al, 2019 ; von Eiff et al, 2001 ; Wheeland et al, 1985 ).…”

Section: Resultsmentioning

confidence: 99%

Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination

Chen

Wang

et al. 2021

Journal of Experimental Medicine

View full text Add to dashboard Cite

A whole-genome CRISPR/Cas9 screen identified ATP2A2, the gene encoding the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 2 protein, as being important for V(D)J recombination. SERCAs are ER transmembrane proteins that pump Ca2+ from the cytosol into the ER lumen to maintain the ER Ca2+ reservoir and regulate cytosolic Ca2+-dependent processes. In preB cells, loss of SERCA2 leads to reduced V(D)J recombination kinetics due to diminished RAG-mediated DNA cleavage. SERCA2 deficiency in B cells leads to increased expression of SERCA3, and combined loss of SERCA2 and SERCA3 results in decreased ER Ca2+ levels, increased cytosolic Ca2+ levels, reduction in RAG1 and RAG2 gene expression, and a profound block in V(D)J recombination. Mice with B cells deficient in SERCA2 and humans with Darier disease, caused by heterozygous ATP2A2 mutations, have reduced numbers of mature B cells. We conclude that SERCA proteins modulate intracellular Ca2+ levels to regulate RAG1 and RAG2 gene expression and V(D)J recombination and that defects in SERCA functions cause lymphopenia.

show abstract

Section: Resultsmentioning

confidence: 99%

Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination

Chen

Wang

et al. 2021

Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…In order to group them, they may be subdivided according to whether they occur in diseases with predominant skin malfunctions or those with hematological/immunological aberrations (Table 1). Concerning skin diseases, EH has often been reported in Darier's disease in addition to AD 28‐31 …”

Section: Hsv and Eczema Herpeticummentioning

confidence: 99%

“…Concerning skin diseases, EH has often been reported in Darier's disease in addition to AD. [28][29][30][31] Case histories have also been published for a variety of other skin diseases such as epidermolysis bullosa simplex, 32 pemphigus foliaceus, 33 Hailey-Hailey disease, 34 pityriasis rubra pilaris, 35 irritant contact dermatitis, 36 staphylococcal scalded skin syndrome, 37 Grover's disease, 38 psoriasis, 39 rosacea, 40 patients with skin grafts, 41 trauma, 42 cosmetic procedures such as follicular hair unit extraction, 43 and severe burns. 44,45 EH has also been described in two patients with ichthyosis vulgaris and a history of AD.…”

Section: H S V and Ec Zema Herpe Ti Cummentioning

confidence: 99%

Eczema herpeticum in atopic dermatitis

Traidl

Roesner

Zeitvogel

et al. 2021

Allergy

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic inflammatory skin disease, which is characteristically associated with intense pruritus and eczematous lesions. 1 Robert Willan, an English dermatologist, was the first to describe the disease in 1808. 2 In most countries, over 20% of children are affected at least once during a period of their lives. [3][4][5] Despite the fact that 85% of all cases manifest before the age of five, AD can occur lifelong and the prevalence of AD is still high in adulthood. 6-8 Surprisingly, recent data based on two birth cohorts revealed that only 38% of adult AD patients in the United Kingdom reported a childhood onset of symptoms. 9Patients suffering from AD are prone to viral and bacterial infections. 5 Staphylococcus aureus (S. aureus) infections are particularly common in AD patients, leading to superinfection. 10

show abstract

“…Eczema herpeticum is an acute HSV infection with localized or generalized occurrence on eczematous skin. Predisposing factors include atopic dermatitis, Hailey-Hailey disease, and Darier disease [71,72]. The existing skin barrier dysfunction facilitates a rapid spread of herpes simplex virus.…”

Section: Eczema Herpeticummentioning

confidence: 99%

Infections with Herpes simplex and Varicella zoster virus

Wilms

Weßollek

Peeters

et al. 2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Human herpes viruses belong to the DNA viruses and are among the most common viral pathogens. Currently, eight human herpes viruses have been characterized. Primary infection is typically followed by virus latency. Viral reactivations are more often symptomatic than primary infections and lead more often to medical consultation. In daily practice, infections with herpes simplex virus (HSV) and varicella zoster virus (VZV) are the most common. If HSV primary infections become clinically manifest, they are often accompanied by systemic symptoms whereas manifest HSV reactivations are usually harmless, self‐limiting and present as grouped vesicles on an erythematous base (herpetiform). Primary VZV infection leads to the clinical picture of varicella (chickenpox). VZV reactivation manifests clinically as shingles and can be accompanied by severe acute neuralgiform pain. In immunosuppression, complicated (necrotizing, ulcerative, hemorrhagic, generalized) manifestations may occur. The diagnosis is usually made clinically. Therapeutic options include topical agents and systemic antivirals. Adequate therapeutic management includes the recognition and treatment of complications such as the possible involvement of other organ systems and pain. Infection during pregnancy may result in transmission to the unborn child.

show abstract

Eczema herpeticum in Darier's disease: a topical storm

Cited by 10 publications

References 8 publications

Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination

Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination

Eczema herpeticum in atopic dermatitis

Infections with Herpes simplex and Varicella zoster virus

Contact Info

Product

Resources

About