Ectopic thyroid tissue localized in submandibular region

Düzer, Sertaç; Akyiğit, Abdulvahap; Sakallıoğlu, Öner; Solmaz, Özgen Arslan; Polat, Cahit

doi:10.5606/kbbihtisas.2016.84666

Cited by 2 publications

(4 citation statements)

References 12 publications

(16 reference statements)

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“…The most common ectopic thyroid site is represented by the tongue (the lingual thyroid is involved in 90% of all ectopic cases; of note, the first ectopic thyroid tissue at this level was described in 1869 by Dr. Hickman in a newborn with rapidly fatal outcome due to respiratory obstruction) followed by various locations (that are called sublingual type [17]) such as submandibular [18], peri-tracheal, larynx, sub-diaphragmatic area [12], etc. Across these 10% of ectopic cases, the most uncommon sites that are only partially understood based on the embryogenetic perspective are at the gastrointestinal level, including the gallbladder [19], adrenal glands, ovaries (struma ovarii), lumbar/renal [19][20][21][22], axillary [23], mammary [24], supra-sellar and suprachiasmatic [25].…”

Section: The Issue Of Ectopic Thyroid Tissuementioning

confidence: 99%

“…Also, a stationary EMT for one year was registered in another ca decision of a conservative approach was based on EBUS-guided biopsy results [118 2.11. Proposed 10-Item Algorithm of EMT Approach 18 F-FDG-PET-CT…”

Section: Outcome After Identification Of Emtsmentioning

confidence: 99%

“…Similarly, a 63-year-old woman was accidentally detected with a nodular intra-pericardial lesion while having a normal thyroid function. CT showed a heterogeneous structure; coronary CT angiography revealed no connection to the coronary artery; ( 18 F-fluorodeoxyglucose) 18 F-FDG-PET was added to further exploration that concluded with a trans-sternal approach. Post-operatory EMT confirmation (2.5 by 2 by 1.5 cm) was followed for one year and showed a good outcome [83].…”

Section: Imaging Features In Emts 241 Ct Scanmentioning

confidence: 99%

“…FNA at clavicle mass confirmed a thyroid malignancy (positive for TTF1, thyroglobulin). 18 F-FDG PET-CT showed multiple hyper-metabolic lymph nodes and EMT uptake (that displaced trachea and esophagus). The 68-year-old female underwent excision of the right clavicular mass followed by total thyroidectomy plus modified right neck dissection (levels 3, 4, and 5) followed by external beam radiation therapy to the distal clavicular region.…”

Section: Complain (Sign or Symptom) Or Scenario Of Emt Detectionmentioning

confidence: 99%

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Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach

Carsote,

Ciobica,

Sima

et al. 2024

Cancers

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We aimed to analyze the management of the ectopic mediastinal thyroid (EMT) with respect to EMT-related cancer and non-malignant findings related to the pathological report, clinical presentation, imaging traits, endocrine profile, connective tissue to the cervical (eutopic) thyroid gland, biopsy or fine needle aspiration (FNA) results, surgical techniques and post-operatory outcome. This was a comprehensive review based on revising any type of freely PubMed-accessible English, full-length original papers including the keywords “ectopic thyroid” and “mediastinum” from inception until March 2024. We included 89 original articles that specified EMTs data. We classified them into four main groups: (I) studies/case series (n = 10; N = 36 EMT patients); (II) malignant EMTs (N = 22 subjects; except for one newborn with immature teratoma in the EMT, only adults were reported; mean age of 62.94 years; ranges: 34 to 90 years; female to male ratio of 0.9). Histological analysis in adults showed the following: papillary (N = 11/21); follicular variant of the papillary type (N = 2/21); Hürthle cell thyroid follicular malignancy (N = 1/21); poorly differentiated (N = 1/21); anaplastic (N = 2/21); medullary (N = 1/21); lymphoma (N = 2/21); and MALT (mucosa-associated lymphoid tissue) (N = 1/21); (III) benign EMTs with no thyroid anomalies (N = 37 subjects; mean age of 56.32 years; ranges: 30 to 80 years; female to male ratio of 1.8); (IV) benign EMTs with thyroid anomalies (N = 23; female to male ratio of 5.6; average age of 52.1 years). This panel involved clinical/subclinical hypothyroidism (iatrogenic, congenital, thyroiditis-induced, and transitory type upon EMT removal); thyrotoxicosis (including autonomous activity in EMTs that suppressed eutopic gland); autoimmune thyroiditis/Graves’s disease; nodules/multinodular goiter and cancer in eutopic thyroid or prior thyroidectomy (before EMT detection). We propose a 10-item algorithm that might help navigate through the EMT domain. To conclude, across this focused-sample analysis (to our knowledge, the largest of its kind) of EMTs, the EMT clinical index of suspicion remains low; a higher rate of cancer is reported than prior data (18.8%), incident imagery-based detection was found in 10–14% of the EMTs; surgery offered an overall good outcome. A wide range of imagery, biopsy/FNA and surgical procedures is part of an otherwise complex personalized management.

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Section: The Issue Of Ectopic Thyroid Tissuementioning

confidence: 99%

Section: Outcome After Identification Of Emtsmentioning

confidence: 99%

Section: Imaging Features In Emts 241 Ct Scanmentioning

confidence: 99%

Section: Complain (Sign or Symptom) Or Scenario Of Emt Detectionmentioning

confidence: 99%

See 2 more Smart Citations

Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach

Carsote,

Ciobica,

Sima

et al. 2024

Cancers

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Follicular adenoma with a papillary architecture originating from an ectopic thyroid gland: a case report

Kuba,

Kawasaki,

Enoki

et al. 2024

BMC Endocr Disord

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Background Follicular adenomas with papillary architecture are rare tumors of thyroid origin and are composed of completely encapsulated follicular cells with a papillary architecture lacking the nuclear characteristics of papillary carcinoma. Herein, we present a case of follicular adenoma with papillary architecture originating from an ectopic thyroid gland, diagnosed from a mass in the submandibular region. Case Presentation A 70-year-old woman was referred to our hospital with the chief complaint of a painless left submandibular mass that had been present for one year. The patient underwent left submandibular dissection for therapy and diagnosis. Microscopically, papillary lesions with fibrovascular cores were observed in the interior, and the epithelial cells were cylindrical in shape with eosinophilic cytoplasm, round or oval nuclei, with no pathological features, leading to a diagnosis of papillary carcinoma or follicular carcinoma. The mass was diagnosed as a follicular thyroid adenoma with papillary architecture. This is the first report of a follicular adenoma with a papillary architecture originating from an ectopic thyroid gland. Conclusion This experience suggests that follicular adenoma should be included in the differential diagnosis of ectopic thyroid tumors.

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Ectopic thyroid tissue localized in submandibular region

Cited by 2 publications

References 12 publications

Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach

Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach

Follicular adenoma with a papillary architecture originating from an ectopic thyroid gland: a case report

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