Ectopic thymoma of the lung; a rare case report and review of the literature

Skoutelis, Kostas; Nikolopoulos, Dimitrios; Markopoulos, Kostas; Chabipi, Katerina; Stoungioti, Sofia; Papastamatiou, M.

doi:10.1186/1757-1626-2-9149

Cited by 12 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Japan, 4,463 cases of mediastinal tumors were surgically treated in 2011; among them, 1,798 were cases of thymoma (40.3 %) [3]. Generally, thymomas arise from thymic rests, and the majority of thymomas (about 90 %) are found in the anterior mediastinum [4]. ectopic thymoma (e.g., neck, trachea, thyroid, lung, pleural cavity or pericardium) is even rare [4].…”

Section: Discussionmentioning

confidence: 98%

“…Generally, thymomas arise from thymic rests, and the majority of thymomas (about 90 %) are found in the anterior mediastinum [4]. ectopic thymoma (e.g., neck, trachea, thyroid, lung, pleural cavity or pericardium) is even rare [4]. These tumors are considered to arise from remnant thymic tissue that fails to migrate into the anterosuperior mediastinum.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Pericardial ectopic thymoma presenting with cardiac tamponade: report of a case

et al. 2014

View full text Add to dashboard Cite

Ectopic thymoma arising from organs other than the thymus, such as the neck, trachea, thyroid, lung and pericardium, is rare. To date, there have been only seven other cases of pericardial thymoma reported in the English literature. We herein report a case of pericardial ectopic thymoma that presented with cardiac tamponade. A 72-year-old Japanese male noticed body weight gain and leg edema. Chest computed tomography (CT) revealed pericardial effusion and an irregularly shaped mass in the pericardial space compressing the right atrium. He was considered to have cardiac tamponade due to a paracardiac tumor that developed following acute cardiac failure. The intraoperative frozen diagnosis was thymoma. Pericardectomy of the thickened pericardium, tumorectomy and thymectomy via a median sternotomy were performed. The final pathological diagnosis was pericardial ectopic thymoma associated with constrictive pericarditis. The differential diagnosis and complete resection of mediastinal tumors such as this rare case of thymoma are important to obtain a better prognosis, as patients with such tumors often present in a state of shock.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Pericardial ectopic thymoma presenting with cardiac tamponade: report of a case

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Most prior reports of ectopic thymoma have indicated that the tumor was located near the thyroid via the normal location of the thymus in the anterior mediastinum, while a few rare reports have indicated that the ectopic thymoma was originated in the thyroid, lung, or right pleura. [2][3][4] To date, there have been no reports of ectopic thymomas in other locations. However, some cases of ectopic thymic cyst occurring in the posterior mediastinum have been reported.…”

Section: Discussionmentioning

confidence: 99%

Ectopic Cervical Thymoma Excised through a Transcervical Approach Combined with Video-assisted Thoracoscopic Surgery: A Case Report

Yokoyama

Hayashida

Yoshiyama

et al. 2015

ATCS

View full text Add to dashboard Cite

Ectopic cervical thymoma (ECT) is a rare tumor. We present a case of 56-year-old woman with an ECT in the anterior neck that was correctly diagnosed preoperatively. The patient had no symptoms of myasthenia gravis or other immune disorders, and the tumor was not invading any adjacent structures. We performed tumor resection and thymectomy through a transcervical approach using video-assisted thoracoscopic surgery with a multi-access single port. To our knowledge, this is a novel combined technique for the resection of an ECT.

show abstract

“…Primary intrapulmonary thymoma is defined as a tumor located below the visceral pleura or entirely circumscribed by lung parenchyma without evidence of a thymic lesion in the anterosuperior mediastinum. Ectopic thymomas have been reported in various sites, such as the middle mediastinum, [23][24][25] neck, 26 thyroid, 27,28 parathyroid, 29 pericardium, 30 pleura, [31][32][33] and lung parenchyma. 34,35 Of note, ectopic thymoma may be mistaken for metastatic carcinoma, especially if it is a first-time diagnosis and demonstrates cytologic atypia.…”

Section: Cancer Cytopathology January 2020mentioning

confidence: 99%

Pitfalls of FNA diagnosis of thymic tumors

Wang

Kundu

Gong

2019

Cancer Cytopathology

View full text Add to dashboard Cite

BACKGROUND: Fine-needle aspiration (FNA), a minimally invasive and cost-effective procedure, often is used in the initial diagnosis of thymic lesions. However, the diagnosis can be challenging. Knowledge of the diagnostic pitfalls is important to improve diagnostic accuracy. METHODS: The authors retrospectively searched the pathology database of The University of Texas MD Anderson Cancer Center for FNA cases using the keywords "thymoma" or "thymic" in cytologic diagnoses or in corresponding final histologic diagnoses rendered from January 2002 to June 2018. The authors reviewed the FNA diagnostic accuracy and pitfalls in comparison with the final histologic diagnoses. RESULTS: A total of 118 FNA cases were identified from 115 patients. The FNA diagnoses were concordant with the final pathologic diagnoses in 110 cases (93.2%), including thymoma (97 cases), atypical thymoma (5 cases), and thymic carcinoma (8 cases). Discrepant FNA and final diagnoses were noted in 8 tumors (6.8%): thymoma versus atypical thymoma/thymic carcinoma (3 tumors), thymoma versus lymphoma (2 tumors), suspicious for lymphoma versus thymoma (1 tumor), and T-lymphoblastic lymphoma versus thymoma (2 tumors). Factors contributing to misinterpretation included intrinsic limitations of the FNA sample (sampling error and a lack of histologic architecture information) and similarities of the cytologic and immunophenotypic features of lymphocyte-rich thymoma and T-lymphoblastic lymphoma. CONCLUSIONS: An accurate FNA diagnosis of thymic tumors can be rendered in the majority of cases. Diagnostic pitfalls can be encountered in rare cases. It is important to handle each case carefully to avoid erroneous diagnoses that may lead to inappropriate treatment.

show abstract

Ectopic thymoma of the lung; a rare case report and review of the literature

Cited by 12 publications

References 13 publications

Pericardial ectopic thymoma presenting with cardiac tamponade: report of a case

Pericardial ectopic thymoma presenting with cardiac tamponade: report of a case

Ectopic Cervical Thymoma Excised through a Transcervical Approach Combined with Video-assisted Thoracoscopic Surgery: A Case Report

Pitfalls of FNA diagnosis of thymic tumors

Contact Info

Product

Resources

About