Ectopic pregnancies after in vitro fertilization and embryo transfer

E, Pyrgiotis; Sultan, Khalid M.; Neal, Gregory S.; Liu, Hung Ching; Grifo, James A.; Rosenwaks, Zev

doi:10.1007/bf02215992

Cited by 43 publications

(39 citation statements)

References 26 publications

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“…Depending on the literature, the incidence of EP among clinical pregnancies resulting from ART is said to be between 2-5% [1,2]. The rate was 1.25% in our clinic, despite the fact that we tried to reduce the incidence 1 Transvaginal ultrasound-guided local injections of absolute ethanol are a safe and effective approach to treating ectopic pregnancies.…”

Section: Introductionmentioning

confidence: 84%

“…The rate was 1.25% in our clinic, despite the fact that we tried to reduce the incidence 1 Transvaginal ultrasound-guided local injections of absolute ethanol are a safe and effective approach to treating ectopic pregnancies. 2 Kato Ladies Clinic, Shinjuku-ku, Tokyo, Japan. 3 Department of Obstetrics and Gynaecology, School of Medicine, Nihon University, Japan.…”

Section: Introductionmentioning

confidence: 99%

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The efficacy and safety of managing ectopic pregnancies with transvaginal ultrasound-guided local injections of absolute ethanol

Kaijima

Osada

Kato

et al. 2006

J Assist Reprod Genet

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Purpose:To describe the efficacy and safety of managing ectopic pregnancies (EP) with ultrasound-guided local injections of absolute ethanol (AE). Methods: 69 cases of EP following IVF performed in our clinic were treated with a local injection of 0.3 ml AE with a 23-gauge needle under transvaginal ultrasonic guidance. The efficacy was evaluated comparing serum beta-human chorionic gonadotropin (β-hCG) levels before and after the injection. Results: In the 60 successful cases (87%), the serum β-hCG level decreased by 10-30% in two hours postinjection. Of these, 46 were effective with a single injection and the half-life of β-hCG was achieved within 4 days in 45 cases. In 56 cases (including repetitive administration) serum β-hCG levels decreased to 20 mIU/mL within 20 days. The treatment showed no side effects and could be given on an outpatient basis without anesthesia. Conclusions: This method was shown to be a safe, effective new approach to treating EP.

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of managing ectopic pregnancies with transvaginal ultrasound-guided local injections of absolute ethanol

Kaijima

Osada

Kato

et al. 2006

J Assist Reprod Genet

View full text Add to dashboard Cite

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“…We finally included seven studies comparing EP rates after frozen versus fresh ET in IVF cycles using autologous oocyte [7][8][9][10][11][12][13] . The clinical characteristics of the included studies are summarized in table 1 .…”

Section: Methodsmentioning

confidence: 99%

“…Two earlier reports in the literature showed conflicting results. A significantly higher [7] and significantly lower [8] EP rate with frozen ET was reported. More recently, data from an abstract suggested a trend for higher EP rates [9,10] after frozen ET.…”

Section: Introductionmentioning

confidence: 99%

Ectopic Pregnancy Rates after Frozen versus Fresh Embryo Transfer: A Meta-Analysis

Jee

Suh

Kim

2009

Gynecol Obstet Invest

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Background/Aims: The aim of this meta-analysis was to determine whether frozen embryo transfer (ET) increases ectopic pregnancy (EP) rate compared with fresh ET. Methods: A meta-analysis was performed of data from seven comparative studies including 13,059 pregnancies that resulted from nondonor in vitro fertilization cycles. Results: The EP rate was 2.31% (49/2,125 pregnancies) for frozen ET and 1.48% (162/10,934 pregnancies) for fresh ET. These rates were statistically not different when assessed either by random (OR 1.66, 95% CI 0.62–4.41) or fixed effect model (OR 1.17, 95% CI 0.84–1.63). Conclusions: The combined data presented in this meta-analysis do not support an increased risk of EP following frozen ET compared with fresh ET. However, as there was a substantial heterogeneity among the studies analyzed, the authors consider that further well-designed studies controlling for several potential biases which could affect the EP risk should be conducted.

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“…Disease distribution examined presented as: ectopic pregnancy (17/42.5%), and from 1 (2.5%) bilateral tubal ligation, chlamydial infection-tubal infertility-ectopic pregnancy ,ectopic pregnancy on patients after IVF with abnormal sperm characteristics, ectopic pregnancy after oocyte donation in menopausal patients, ectopic pregnancy after donation surviving even with the absence of exogenous steroids, ectopic pregnancy after embryos with thickened zona pellucida, ectopic pregnancy after empty follicle syndrome, ectopic pregnancy after exposure to levonorgestrel, heterotopic abdominal pregnancy, heterotopic abdominal pregnancy, ectopic pregnancy after hydrosalpinx, menopause and oocyte donation, ovarian heterotopic pregnancy, ectopic pregnancy after pelvic inflammatory disease, pelvic inflammatory disease-ectopic pregnancy and neonatal complications, primary infertility, tubal factor infertility and bilateral ovarian pregnancy, tubal sterilization while 3 (7.5%) did not mentioned disease. Funding source of each study per Journal published is seen on Fig 8. www.intechopen.com (n=405) showing a 2.4% and 7.6% EP rate, respectively (Pyrgiotis et al, 1994). Tubal factor presented as 85.7% of all causes of ectopic pregnancies.…”

Section: Ectopic Pregnancy and Ivfmentioning

confidence: 98%