Ectopic pituitary adenoma of the TSH-secreting sphenoidal sinus with excellent response to somatostatin analogs. Theory of the embryogenesis and literature review from a clinical case

Ortiz, Eugenia; Peldoza, Marcelo; Monnier, Eduardo; Gejman, Roger; Henriquez, Miguel; Barra, María Inés; Gayoso, Roxana; Sapunar, J; Villaseca, Miguel; Guzmán, Pablo

doi:10.1016/j.steroids.2019.108535

Cited by 15 publications

(12 citation statements)

References 17 publications

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“…Articles were excluded if the cases were not ectopic TSH-oma or the diagnosis was not histologically confirmed. The results of searching PubMed yielded only 11 cases of ectopic TSH-oma (Table 1) (6,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Of all 12 patients, seven (58.33%) were females, and five (41.67%) were males, indicating a female predominance at a ratio of 1.4:1.…”

Section: Discussion Ectopic Tsh-omamentioning

confidence: 99%

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Zhao

Hou

et al. 2021

Front. Endocrinol.

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Ectopic thyrotropin-secreting pituitary adenoma (ectopic TSH-oma) is a rare disorder that is easily misdiagnosed in clinical work. We report one patient who presented with hyperthyroidism and a suprasellar mass. In this case, preoperative diagnosis of suprasellar ectopic thyrotropin-secreting pituitary adenoma was challenging. A literature review revealed that a total of 11 patients with ectopic TSH-oma were previously reported, and only our one case was diagnosed in the microadenoma stage. Most of the patients with TSH-oma or ectopic TSH-oma were middle-aged. We described ectopic TSH-oma in a child at length. We recommend that ectopic TSH-oma should be considered in the differential diagnosis of thyrotoxicosis syndrome to achieve an accurate, early diagnosis. The somatostatin suppression test and imaging examinations, such as magnetic resonance imaging and positron emission tomography/magnetic resonance imaging, could contribute to the diagnosis. Once the diagnosis was highly suspected, tumor resection could achieve a satisfying long-term outcome in ectopic TSH-oma.

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Section: Discussion Ectopic Tsh-omamentioning

confidence: 99%

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Zhao

Hou

et al. 2021

Front. Endocrinol.

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“…In 2016, Wang et al (35) reported the first ectopic TSH PitNET located on the intracranial sella. Ectopic TSH PitNETs located on sphenoid sinus and orbit have been respectively first reported in 2020 (36).…”

Section: Imaging Manifestationsmentioning

confidence: 99%

Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor

et al. 2020

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TSH-secreting pituitary neuroendocrine tumor (PitNET) is one of the causes of central hyperthyroidism. The incidence of TSH PitNET is far lower than that of other PitNETs. The clinical manifestations of TSH PitNETs mainly include thyrotoxicosis or thyroid goiter, secretion disorders of other anterior pituitary hormones, and mass effect on the pituitary gland and its surrounding tissues. The application of high-sensitivity TSH detection methods contributes to the early diagnosis and timely treatment of TSH PitNETs. Improvements in magnetic resonance imaging (MRI) have advanced the noninvasive visualization of smaller PitNETs. Treatments for TSH PitNETs include surgery, drugs, and radiotherapy. This review focuses on the progress in pathogenesis, diagnosis, and treatment of TSH PitNETs to provide more information for the clinician.

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“…In this light, some authors suggest to routinely perform hormone evaluation in the presence of a parasellar lesion, since this may facilitate an early diagnosis and potentially avert an unnecessary biopsy and/or surgical intervention. Indeed, in recent years, some cases of PRL-secreting EPTs have been successfully treated using medical therapy with dopamine-agonists [50], and both GH-and TSH-secreting ETPs are supposed to benefit from treatment with somatostatin receptor ligands [57][58][59].…”

Section: Doi: 101159/000506905mentioning

confidence: 99%

Diagnosis and Treatment of Parasellar Lesions

et al. 2020

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The parasellar region, located around the sella turcica, is an anatomically complex area representing a crossroads for important adjacent structures. Several lesions, including tumoral, inflammatory vascular, and infectious diseases may affect this area. Although invasive pituitary tumors are the most common neoplasms encountered within the parasellar region, other tumoral (and cystic) lesions can also be detected. Craniopharyngiomas, meningiomas, as well as Rathke's cleft cysts, chordomas, and ectopic pituitary tumors can pri

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Ectopic pituitary adenoma of the TSH-secreting sphenoidal sinus with excellent response to somatostatin analogs. Theory of the embryogenesis and literature review from a clinical case

Cited by 15 publications

References 17 publications

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor

Diagnosis and Treatment of Parasellar Lesions

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