Ectopic pancreas in gallbladder. Clinical significance, diagnostic and therapeutic implications

Cárdenas, Elena Margarita Sanchiz; Humanes, R Soler; Fernandez, Ana Isabel Lavado; Nieto, Rafael Díaz; Muñóz, Miguel Ángel Suárez

doi:10.17235/reed.2015.3627/2014

Cited by 12 publications

(31 citation statements)

References 3 publications

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“…The presence of heterotopic pancreas has been described in the stomach, duodenum, jejunum, and spleen; it is rarely found in the ileum, liver, gallbladder, bile ducts, mesentery, lungs, mediastinum, and fallopian tubes [1,3,[6][7][8][9]. Approximately 90% of the cases are located in the upper gastrointestinal tract [2].…”

Section: Discussionmentioning

confidence: 99%

“…Results showed two polyps in the gallbladder, wherein the largest polyp measured 0.7 × 0.5 cm. Repeat ultrasonography after 6 months showed Histologically, the exocrine and endocrine components of the pancreas can be found in pancreatic heterotopic sites, including full differentiation of the islet in one-third of cases [1,2,9].…”

Section: Case Reportmentioning

confidence: 99%

“…Although it is generally asymptomatic, heterotopic pancreas may become clinically evident when complicated by pathological alterations such as inflammation, hemorrhage, obstruction, and malignant transformation [8,9].…”

Section: Case Reportmentioning

confidence: 99%

“…The incidence of pancreatic heterotopia generally ranges from 0.55% to 13.7% in autopsy series and 0.2% in laparotomies [1,4,8,9]. Few cases have been reported regarding the presence of ectopic pancreas in the gallbladder, most of them being an incidental finding after cholecystectomy for cholecystitis [9].…”

Section: Introductionmentioning

confidence: 99%

“…Few cases have been reported regarding the presence of ectopic pancreas in the gallbladder, most of them being an incidental finding after cholecystectomy for cholecystitis [9]. The clinical significance of the presence of heterotopic pancreas in the gallbladder is unclear [5,9].…”

Section: Introductionmentioning

confidence: 99%

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Ectopic pancreatic tissue in a Gallbladder

Baú¹,

Lucchese²,

Hohmann³

et al. 2016

SOJS

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SOJ SurgeryOpen Access Case Report that polyp size increased to 1.0 × 0.5 cm, for which the patient underwent laparoscopic cholecystectomy. Family history showed that the patient's 80-year-old father and 54-year-old sister died of pancreatic and colon cancers, respectively. The pathology report described the presence of ectopic pancreas in the gallbladder wall [ Figure 1] and polyp cholesterolosis. DiscussionThe presence of heterotopic pancreas has been described in the stomach, duodenum, jejunum, and spleen; it is rarely found in the ileum, liver, gallbladder, bile ducts, mesentery, lungs, mediastinum, and fallopian tubes [1,3,[6][7][8][9]. Approximately 90% of the cases are located in the upper gastrointestinal tract [2]. The stomach is the most frequent site (25-38% of cases), followed by the duodenum (30%) and the jejunum (15%). In the ileum, the heterotopic pancreas may be associated with Meckel's diverticulum, intestinal obstruction, or intussusception [4]. Only 33 cases of ectopic pancreas in the gallbladder have been described until 2013 [7].A review of 212 cases of ectopic pancreatic tissue in the Mayo Clinic found only one instance in the gallbladder [6].Heterotopic pancreas can be diagnosed at all ages, being more frequent in men; however, a higher incidence of heterotopic pancreas in the gallbladder is found in women [8]. This condition can occur in all age groups, but 50% of cases are diagnosed between the fourth and sixth decades of life [4,6]. AbstractEctopic or heterotopic pancreas is an abnormality of embryological origin and is defined as the presence of pancreatic tissue histologically identified outside the normal topography without any anatomical, vascular, or neural connection with the gland. Is a rare pathologic condition, but with the potential to cause severe symptoms sometimes attributed to idiopathic causes.The authors present an asymptomatic patient who underwent laparoscopic cholecystectomy for polyps, and the pathology report describes the presence of associated pancreatic tissue. A brief review of the literature is also presented.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ectopic pancreatic tissue in a Gallbladder

Baú¹,

Lucchese²,

Hohmann³

et al. 2016

SOJS

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Ectopic pancreatic tissue in a cholecystectomy specimen: A rare incidental pathologic finding

Zaresharifi,

Khalili,

Eftekhari

et al. 2023

Clinical Case Reports

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Ectopic pancreatic tissue is a rare congenital abnormality defined as the abnormal location of pancreatic tissue outside the anatomical site of the pancreas without any anatomical or vascular connection to it, which is often discovered incidentally. This is a case of a 40‐year‐old man who was admitted to our surgical department for emergency cholecystectomy due to acute gangrenous cholecystitis. Preoperative ultrasound imaging was indicative only of multiple stones in the gallbladder. Postoperative histopathological examination revealed an area of wall thickening in the neck region of the gallbladder consists of ectopic pancreatic tissue. We emphasize the role of a precise pathologic examination even in routine surgical specimens such as a cholecystectomy specimen, since no preoperative evaluation can be affirmative of such incidental but momentous histopathologic findings. Anatomical pathologists must be aware of the rare presentation of Ectopic Pancreatic Tissue (EPT) in gallbladder which may masquerade as a malignancy.

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A case report of ectopic pancreatic tissue in the gallbladder

Rensburg

Raufian

2022

Journal of Surgical Case Reports

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Heterotropic pancreatic tissue is a rare entity where aberrant pancreatic tissue is located without any anatomical connection to the pancreas. It is usually reported to be found in stomach, duodenum, jejunum and spleen. Rare locations include lung, mediastinum, liver, mesentery, ileum, meckels diverticulum and gallbladder [1, 2]. This anomaly is often an incidental finding during laparotomy or autopsy. We describe a case of an elective laparoscopic cholecystectomy with the histology of the gallbladder showing focal ectopic pancreatic acinar tissue.

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Ectopic pancreas in gallbladder. Clinical significance, diagnostic and therapeutic implications

Cited by 12 publications

References 3 publications

Ectopic pancreatic tissue in a Gallbladder

Ectopic pancreatic tissue in a Gallbladder

Ectopic pancreatic tissue in a cholecystectomy specimen: A rare incidental pathologic finding

A case report of ectopic pancreatic tissue in the gallbladder

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