Ectopic ossification in hip arthroplasty: A retrospective study of predisposing factors in 637 cases

Heterotopic ossification after total hip replacement and the HLA system in the Sicilian population

“…However, the identification of some risk factors has led to the use of preventive treatment to limit the onset of HO and has resulted in theories on the pathogenesis HO formation. Systemic and local risk factors of HO have been identified [1][2][3]. The former include sex (male predominance), old age, obesity, osteoporosis and concomitant diseases, such as hypertrophic arthritis, ankylosing spondylitis, Parkinson's disease, and cranial and spinal cord injuries.…”

Short-term ibuprofen to prevent ossification after hip arthroplasty:No effects in a prospective randomized study of 47 arthrosis cases

“…Since the tendency among men to develop heterotopic bone is greater than for women (DeLee et al 1976, Sfihalle et al 1988, Ahrengart and Lindgren 1993, Nollen and van Douveren 1993. we also analyzed the male patients separately.…”

Editorial: Heterotopic ossification

“…This great variation is due to different definitions of HO, differences in the surgical procedures, but also different prevalences of risk factors in the patient populations. Using a radiographic definition, new bone in the periprosthetic soft tissues occurs in about 60% of the patients (Nollen and van Douveren 1993). More rarely, HO occurs after prosthetic replacement or trauma to other joints, such as the knee or shoulder, or following trauma to muscles.…”

“…1) Patients with a previous history of HO almost invariably develop HO after hip arthroplasty (Sodemann et al 1988, Nollen andvan Douveren 1993).…”

“…2 ) Men are more prone to HO than women and the extent of heterotopic bone is also greater (Ritter and Vaughan 1977, Ahrengardt and Lindgren 1993, Nollen and van Douveren 1993.…”