Ectopic
            <i>β</i>
            -Human Chorionic Gonadotropin Production by Bladder Urothelial Neoplasia

Shah, Veer; Newman, Joseph T.; Crocker, John F. S.; Chapple, Christopher R.; Collard, M; O’Brien, J.M.; Considine, Julie

doi:10.1016/s0022-5347(17)45146-9

Cited by 14 publications

(32 citation statements)

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“…These sections included both of the patients who had elevated serum levels with tumour present (one patient with raised serum level had no sign of recurrence) but unfortunately only one of the three cases with raised serum and urinary levels of BhCG. Shah et al (1986) observed that the production of BhCG is often very localised and our negative result could reflect sampling error of the sections obtained. Alternatively the immunohistochemical method may be less sensitive than the polyclonal assay (which recognises the beta HCG core fragment).…”

Section: Discussionmentioning

confidence: 70%

“…Using immunoperoxidase staining both Shah et al (1986) and Rodenburg et al (1985) observed BhCG production in poorly differentiated tumours and it has been suggested that a process of tumour de-differentiation was responsible for the production of BhCG (Shah et al, 1986). Iles et al (1987) however were able to demonstrate BhCG production in both neoplastic and non neoplastic cell lines suggesting that BhCG secretion is an innate property of bladder epithelium.…”

Section: Discussionmentioning

confidence: 98%

“…It has been suggested that in urinary estimation of these substances may be a more reliable reflection of secretion (Nam et al, 1990). In addition, in view of the fact that the bladder tumour is the direct site of production of the BhCG (Iles et al, 1987;Shah et al, 1986;Rodenburg et al, 1985) it could be expected that the highest levels would be found in the urine. In this study however no patient was observed to have an elevated early morning urinary BhCG level in the presence of a serum level within the normal range.…”

Section: Discussionmentioning

confidence: 99%

“…Shah et al (1986) identified sites of BhCG production in the cytoplasm of cells in high-grade bladder tumours using immunoperoxidase staining techniques. Dexeux et al (1986) found that serum BhCG levels were elevated in 30% of cases with advanced bladder cancer and when elevated by greater than 50% than normal correlated well with the clinical course.…”

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confidence: 99%

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Serum and urinary levels of beta human chorionic gonadotrophin in patients with transitional cell carcinoma

McLoughlin

Pepera²,

Bridger³

et al. 1991

Br J Cancer

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Summary Serum and early morning urine specimens were obtained from 62 patients. The levels of beta human chorionic gonadotrophin (BhCG) in both serum and urine were estimated simultaneously in all cases. At the time of estimation 43 patients had transitional cell carcinoma of the bladder, one had transitional cell carcinoma of the renal pelvis and three had carcinoma in situ (two of whom also had overt carcinoma). Raised serum and urinary levels were found in only three patients, all of whom had poorly differentiated or metastatic transitional cell carcinoma of the bladder. This observation is in accordance with previous studies. In one of these patients, who underwent transurethral resection of her bladder tumour, the urinary levels returned to within normal limits post resection. An Recently it was postulated that the secretion of hCG and its beta subunit (BhCG) was an innate property of bladder epithelium, whether it be neoplastic or non neoplastic (Iles et al., 1987). This would suggest that BhCG levels may be measurable in the serum and urine of patients with tumours of better differentiation.The present study was undertaken to assess the merit of using BhCG levels as a tumour marker in bladder cancer. Materials and methods

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Serum and urinary levels of beta human chorionic gonadotrophin in patients with transitional cell carcinoma

McLoughlin

Pepera²,

Bridger³

et al. 1991

Br J Cancer

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“…Recently, HCG-producing elements have been identi fied in bladder tumors using immunohistochemical pro cedures [5,6,8,[10][11][12], HCG-producing cells have been reported to occur in tumors that showed severe cytological abnormality. In the present case, the specimens from the bladder lesions were grade 3 transitional cell carcino ma.…”

Section: Discussionmentioning

confidence: 99%

Gynecomastia and Ectopic Human Chorionic Gonadotropin Production by Transitional Cell Carcinoma of the Bladder

Nishiyama

Washiyama²,

Tanikawa³

et al. 1992

Urol Int

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We report a patient with gynecomastia and ectopic production of human chorionic gonadotropin (HCG) by a transitional cell carcinoma of the bladder. In the present case, serum HCG levels and gynecomastia paralleled the clinical course. On admission, the patient was suffering from invasive transitional cell carcinoma (grade 3) of the bladder with metastasis to the left inguinal lymph nodes, together with gynecomastia. The serum HCG level was also elevated. After anticancer chemotherapy, the apparent bladder lesion and gynecomastia disappeared, and the serum HCG level declined to within normal limits. About 2 months after discharge, when the patient suffered from recurrent invasive tumors of the bladder, gynecomastia reappeared and the serum HCG level again became elevated. Β-HCG was demonstrated in biopsy tissue using the immunoperoxidase technique. The presence of Β-HCG was always focally demonstrated and was shown to be localized in the cytoplasm of the tumor cells.

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Urothelial carcinoma of the bladder with trophoblastic differentiation: A case report

et al. 2004

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We report a case of a urothelial carcinoma with trophoblastic differentiation of the bladder that occured in a 23-year-old man. The patient presented with hematuria. Multiple papillary masses were resected transurethrally. Histopathologically, grade III urothelial cell carcinoma contained giant cells that were positive for human chorionic gonadotrophin (HCG), placental alkalen phosphatase, and human placental lactogen. HCG secreting tumors are reported to be highly aggressive. The patient is alive and well without evidence of recurrent disease or metastasis at 10 months from transurethral resection. To our knowledge, this case is the youngest patient in the literature so far.

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Ectopic β -Human Chorionic Gonadotropin Production by Bladder Urothelial Neoplasia

Cited by 14 publications

References 0 publications

Serum and urinary levels of beta human chorionic gonadotrophin in patients with transitional cell carcinoma

Serum and urinary levels of beta human chorionic gonadotrophin in patients with transitional cell carcinoma

Gynecomastia and Ectopic Human Chorionic Gonadotropin Production by Transitional Cell Carcinoma of the Bladder

Urothelial carcinoma of the bladder with trophoblastic differentiation: A case report

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