Ectopic hamartomatous thymoma containing myoid cells

Saeed, Imran; Fletcher, CD

doi:10.1111/j.1365-2559.1990.tb00800.x

Cited by 28 publications

(21 citation statements)

References 5 publications

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“…2c). However, they were negative for desmin, as reported previously in EHTs [1,19]. Other muscular markers, MyoD and muscle actin, were also negative (data not shown).…”

Section: Immunohistochemical and Histochemical Findingssupporting

confidence: 83%

“…In the two previous EHT cases in which myoid cells were observed, the myoid cells stained positive for myoglobin. In one of these cases, the myoid cells also stained positive for human muscle actin [1,19]. In this paper, we found that when using immunostaining on step sections of the tumor specimen, the myoid cells stained positive for not only myoglobin and CK-mm but also for cytokeratin and EMA.…”

Section: Discussionmentioning

confidence: 73%

“…To date, 24 cases have been reported in the literature (Table 1). Among these cases, myoid cells have only appeared in two patients [1,19].…”

Section: Introductionmentioning

confidence: 99%

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Two cases of ectopic hamartomatous thymoma

et al. 2000

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Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm. Since it was named by Rosai et al. in 1984, 24 cases have been reported. We herein report two cases of EHT, one of which presented with massive myoid cells, and review the literature related to EHT. Both of our cases displayed the typical features of EHT: (1) nests of epithelial cells, including solid, cystic, or glandular epithelial islands; (2) spindle cells dominating the microscopic picture; and (3) adipose cells which intermingle haphazardly to impart a hamartomatous quality to the tumor. In this paper, we observed massive myoid cells and the transition from spindle epithelial cell to myoid cell in one of our cases. Immunohistochemical examinations showed that the main component of EHT, spindle cells, was positive for cytokeratin and epithelial membrane antigen (EMA). Intriguingly, the myoid cells simultaneously expressed cytokeratin, EMA, myoglobin, and creatine kinase-mm, suggesting that myoid cells may originate from epithelial cells and are an intermediate state between epithelial cells and muscular cells.

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“…2c). However, they were negative for desmin, as reported previously in EHTs [1,19]. Other muscular markers, MyoD and muscle actin, were also negative (data not shown).…”

Section: Immunohistochemical and Histochemical Findingssupporting

confidence: 83%

Section: Discussionmentioning

confidence: 73%

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Two cases of ectopic hamartomatous thymoma

et al. 2000

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“…4 The presence of striated muscle or rhabdomyomatous elements in the thymus can occur in several settings, the most obvious being in the context of a teratoma. However, skeletal muscle (benign or malignant) may be encountered in rhabdomyomatous thymoma, 5 thymolipoma, 6 ectopic hamartomatous thymoma, 7,8 anterior mediastinal rhabdomyosarcoma, and thymic carcinosarcoma 9 and as part of a so-called thymic blastoma. 10 To our knowledge, this report is the first description of rhabdomyomatous foci associated with a multilocular thymic cyst.…”

mentioning

confidence: 99%

Rhabdomyomatous Multilocular Thymic Cyst

Chetty

Reddi

2003

Am J Clin Pathol

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The thymus is the seat of a diverse array of pathologic conditions given its embryologic roots. Multilocular thymic cysts, although well described, are uncommon, and one associated with rhabdomyomatous elements has not been described previously. A 15-year-old boy complained of sudden-onset chest pain of a month's duration, but was otherwise well. Chest radiographs localized the mass to the anterior mediastinum, arising from the thymus. A computed tomography scan demonstrated the lesion to be a multilocular fluid-containing cyst. A large, 15-cm cyst contiguous with the thymus was removed. Histologic evaluation confirmed a multilocular cyst lined mainly by mucinous epithelium with focal areas of ciliated and squamous lining. A prominent finding was skeletal muscle elements in the form of spider cells, strap-like cells, and foci reminiscent of fetal-type muscle with cross-striations. At the periphery of the cyst, thymic tissue with branching ducts and Hassall corpuscles were noted. No evidence of skin and/or its appendage structures, cartilage, or other differentiated tissue was seen despite generous sampling of the specimen. The muscle elements, most likely, were derived from thymic myoid cells, while the multilocular cyst arose from remnants of the thymomedullary system.

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“…Table 1 shows a summary of the cases of ectopic hamartomatous thymoma that have been reported since 1990. [2][3][4][5][6][8][9][10][11][12][13][14][15][16][17][18][19][20] These tumors are common during the third and fourth decades, with a marked male predominance. They most often arise in the lower neck region, in particular the supraclavicular or suprasternal region, and are located either superfi cially or deep in the sternocleidomastoid muscle.…”

Section: Discussionmentioning

confidence: 99%

Ectopic hamartomatous thymoma — A truly rare neoplasm: Report of a case

et al. 2010

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An ectopic hamartomatous thymoma is an extremely rare benign neoplasm that commonly occurs in the lower neck region. It has distinctive pathological features that include haphazardly arranged spindle cells, epithelial cells, and mature fat tissue. Its histogenesis is still controversial. This report presents a case of a 26-year-old man with ectopic hamartomatous thymoma in the left supraclavicular region, and discusses the current knowledge regarding this type of lesion. Clinicians as well as pathologists should be aware of the existence of this disease so that it can be identified correctly.

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Ectopic hamartomatous thymoma containing myoid cells

Cited by 28 publications

References 5 publications

Two cases of ectopic hamartomatous thymoma

Two cases of ectopic hamartomatous thymoma

Rhabdomyomatous Multilocular Thymic Cyst

Ectopic hamartomatous thymoma — A truly rare neoplasm: Report of a case

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