Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway

The Angiogenic Factor Angiopoietin-1 Is a Proneurogenic Peptide on Subventricular Zone Stem/Progenitor Cells

“…The Tie-2 receptor is found in neurons (Valable et al, 2003;Kosacka et al, 2005) and glial cells such as Schwann cells and glioblastoma cells (Poncet et al, 2003;Lee et al, 2006;Makinde and Agrawal, 2008). In addition, Tie-2 expression is found in stem cells, including embryonic stem cells from human (Parati et al, 2002) and mouse brains (Bai et al, 2009a), rat liver stem cells (Kuroda et al, 2002), and hematopoietic and mesenchymal stem cells (Huang et al, 1999;Yuasa et al, 2002). Expression outside the vascular compartment suggests a wider biological role of the Ang-1/Tie-2 system than that previously thought and Ang-1 may regulate stem cell dynamic.…”

“…In hematopoietic stem cells, Ang-1/Tie-2 is crucial for the maintenance of the stem cell state (Hirao et al, 2004). Moreover, Ang-1 elicits neuronal differentiation and neurite outgrowth in mouse embryonic cortical and dorsal root ganglion cells (Kosacka et al, 2005;Bai et al, 2009a). After cortical and striatal stroke, angiogenic remodeling is accompanied by neurogenesis in the peri-infarct area and in the SVZ.…”

Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1

“…This signaling module plays a pivotal role in the regulation of cell survival, proliferation, and size in many systems (25)(26)(27)(28). In fact, a number of studies has suggested the roles of the PI3K-Akt pathway in NPC proliferation and/or differentiation (29)(30)(31)(32)(33). However, even though PDK1 and all 3 members of the Akt family are expressed in the developing CNS, genetic evidence for their importance in CNS development is lacking.…”

Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia

“…In our study, Ang-1 protein was concentrated not only in brain microvascular endothelial cells constructing the vascular structures, but also in the nerve tissue of the penumbra area, which may indirectly indicate that the Ang-1/ Tie-2 signal has a combinative role in the neurorestorative process. Reports also suggest that the expression of Ang-1 was found in neurons and neural stem cells, and that exogenous Ang-1 promotes the survival of neurons and neural progenitor cells after exposure to serum deprivation or hypoxia (Valable et al, 2003;Bai et al, 2009). Ang-1 also elicits neuronal differentiation and neurite outgrowth in mouse embryonic cortical and dorsal root ganglion cells (Kosacka et al, 2005;Bai et al, 2009).…”

“…Reports also suggest that the expression of Ang-1 was found in neurons and neural stem cells, and that exogenous Ang-1 promotes the survival of neurons and neural progenitor cells after exposure to serum deprivation or hypoxia (Valable et al, 2003;Bai et al, 2009). Ang-1 also elicits neuronal differentiation and neurite outgrowth in mouse embryonic cortical and dorsal root ganglion cells (Kosacka et al, 2005;Bai et al, 2009). After cortical and striatal stroke, ischemia elicits an up-regulation of Ang-1 and the migration of the doublecortin (DCX)-positive neuroblasts from the subventricular zone to the peri-infarct area (Yamashita et al, 2006;Shin et al, 2008).…”