Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation

Sun, Qian; Tu, Huiyin; Xing, Guo-Gang; Han, Ji-Sheng; Wan, You

doi:10.1016/j.expneurol.2004.09.008

Cited by 71 publications

(55 citation statements)

References 42 publications

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“…The frequency of ectopic discharges shows a transient increase within the first 24 hrs following spinal nerve ligation (Sun et al, 2005). Based on this it was concluded that ectopic discharges may only contribute to the initiation of mechanical allodynia (Sun et al, 2005). In that same study, however, the pattern of the discharges was altered throughout the observation period (14 days) (from tonic and bursting to irregular).…”

Section: Peripheral Nerve Injury Alters the Dorsal Root Ganglia Envirmentioning

confidence: 78%

“…Following sciatic nerve injury (constriction or cutting), ectopic discharges (firing of action potentials) from the injured site (Tal and Eliav, 1996;Wall and Gutnick, 1974a;Wall and Gutnick, 1974b;Wall and Devor, 1983) and the dorsal root ganglia (Amir et al, 2002;Liu et al, 2000a;Liu et al, 1999;Liu et al, 2000b) correlate with the development of neuropathic pain. The frequency of ectopic discharges shows a transient increase within the first 24 hrs following spinal nerve ligation (Sun et al, 2005). Based on this it was concluded that ectopic discharges may only contribute to the initiation of mechanical allodynia (Sun et al, 2005).…”

Section: Peripheral Nerve Injury Alters the Dorsal Root Ganglia Envirmentioning

confidence: 99%

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An Approach to Identify Nerve Injury-Evoked Changes that Contribute to the Development or Protect Against the Development of Sustained Neuropathic Pain

Recio-Pinto¹,

Norcini²,

Blanck³

2012

Basic Principles of Peripheral Nerve Disorders

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Section: Peripheral Nerve Injury Alters the Dorsal Root Ganglia Envirmentioning

confidence: 78%

Section: Peripheral Nerve Injury Alters the Dorsal Root Ganglia Envirmentioning

confidence: 99%

An Approach to Identify Nerve Injury-Evoked Changes that Contribute to the Development or Protect Against the Development of Sustained Neuropathic Pain

Recio-Pinto¹,

Norcini²,

Blanck³

2012

Basic Principles of Peripheral Nerve Disorders

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“…The origination of the spontaneous activities of WDR neurons is elusive, and the following possibilities have been proposed. One possibility is the ectopic firings from the injured site of L5 and the DRG [33] . Another possibility is the spontaneous activities in the uninjured L4 primary afferent fibers adjacent to the injured fibers [34] .…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation

Liu

Cai

et al. 2011

Neurosci. Bull.

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Objective The present study aimed to investigate the electrophysiological properties of wide dynamic range (WDR) neurons in spinal dorsal horn of rats with neuropathic pain induced by lumber 5 (L5) spinal nerve ligation (SNL) in a large size of samples. Methods Adult Sprague-Dawley rats were divided into normal and SNL groups. Electrophysiological technique was used to record the characteristics of WDR neurons in the spinal dorsal horn. Results Compared with the WDR neurons in normal rats, the WDR neurons in SNL rats showed an increase in excitability, manifested by an enlargement of the receptive field size, an increase in the proportion of neurons that exhibited spontaneous activities, decreases in the Cresponse threshold and latency, and an increase in the C-response duration. In addition, the numbers of A  -and C-fiberevoked discharges were smaller in SNL rats than in normal rats. Conclusion The excitability of spinal WDR neurons increased in rats with neuropathic pain induced by L5 SNL. The increase in excitability of WDR neurons may contribute to the development of neuropathic pain.

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“…One hypothesis suggests that central sensitization at the level of the spinal dorsal horn is maintained independently of primary afferent input (Sandkuhler and Liu, 1998) since input from the periphery is reportedly insufficient to maintain spinal modifications in sensory processing and ultimately neuropathic pain (Burgess et al, 2002;Sun et al, 2005;Xie et al, 2005). Another view suggests that mechanisms at the spinal dorsal horn level require continuous facilitatory input from supraspinal structures Carlson et al, 2007;Gardell et al, 2003;Kauppila et al,1998;Kovelowski et al, 2000;Ossipov et al, 2000;Pertovaara et al, 1997Pertovaara et al, , 2001Porreca et al, 2001;Saade et al, 2006aSaade et al, ,b, 2007Suzuki et al, 2002Suzuki et al, , 2004aVeraPortocarrero et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy

Pitcher

Henry

2008

Experimental Neurology

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Previously we reported that the cuff model of peripheral neuropathy, in which a 2 mm polyethylene tube is implanted around the sciatic nerve, exhibits aspects of neuropathic pain behavior in rats similar to those in humans and causes robust hyperexcitation of spinal nociceptive dorsal horn neurons. The mechanisms mediating this increased excitation are not known and remain a key unresolved question in models of peripheral neuropathy. In anesthetized adult male Sprague-Dawley rats 2-6 weeks after cuff implantation we found that elevated discharge rate of single lumbar (L 3-4 ) wide dynamic range (WDR) neurons persists despite acute spinal transection (T9) but is reversed by local conduction block of the cuff-implanted sciatic nerve; lidocaine applied distal to the cuff (i.e. between the cuff and the cutaneous receptive field) decreased spontaneous baseline discharge of WDR dorsal horn neurons ~40% (n=18) and when applied subsequently proximal to the cuff, i.e. between the cuff and the spinal cord, it further reduced spontaneous discharge by ~60% (n=19; P<0.05 proximal vs. distal) to a level that was not significantly different from that of naive rats. Furthermore, in cuff-implanted rats WDR neurons (n=5) responded to mechanical cutaneous stimulation with an exaggerated afterdischarge which was reversed entirely by proximal nerve conduction block. These results demonstrate that the hyperexcited state of spinal dorsal horn neurons observed in this model of peripheral neuropathy is not maintained by tonic descending facilitatory mechanisms. Rather, on-going afferent discharges originating from the sciatic nerve distal to, at, and proximal to the cuff maintain the synapticallymediated gain in discharge of spinal dorsal horn WDR neurons and hyperresponsiveness of these neurons to cutaneous stimulation. Our findings reveal that ectopic afferent activity from multiple regions along peripheral nerves may drive CNS changes and the symptoms of pain associated with peripheral neuropathy.

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Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation

Cited by 71 publications

References 42 publications

An Approach to Identify Nerve Injury-Evoked Changes that Contribute to the Development or Protect Against the Development of Sustained Neuropathic Pain

An Approach to Identify Nerve Injury-Evoked Changes that Contribute to the Development or Protect Against the Development of Sustained Neuropathic Pain

Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation

Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy

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