Ectopic Brain Tissue in the Orbit: 5-Year Follow-up

Abstract

A neonate presented with a dilated pupil of the left eye. Magnetic Resonance Imaging (MRI) showed a mass in the left inferior part of the orbit. Incisional biopsy was performed. Histopathological examination revealed ectopic brain tissue. The patient had a 5-year follow-up without any growth on MRI. Ectopic brain tissue in the orbit is a rare finding in the literature, almost all involved infants or neonates. Pathogenesis is still unknown.

Retroperitoneal ectopic brain: Case report and literature review

“…As for the prognosis, they are considered to be benign lesions with a limited growth potential . However, incomplete resection can lead to recurrences and isolated cases of malignant transformation have been described …”

“…1,12 As for the prognosis, they are considered to be benign lesions with a limited growth potential. 1,5 However, incomplete resection can lead to recurrences and isolated cases of malignant transformation have been described. 12 The mainstay for treatment of HNT is early complete resection to prevent functional or aesthetic defects.…”

“…Most cases occur in head and neck region and consist of glial tissue (nasal glioma or nasal glial heterotopia) . HNT has been also observed in nasopharynx, oropharynx, skull, tongue, middle ear, orbit, lips, scalp, lung, peritoneum, or ovary …”

“…2 HNT has been also observed in nasopharynx, oropharynx, skull, tongue, middle ear, orbit, lips, scalp, lung, peritoneum, or ovary. [3][4][5][6][7] In our literature review we have only found two cases of HNT located in retroperitoneum. 8,9 As far as we know, cytological features of HNT have not yet been described.…”