Ectopic ACTH Syndrome in APUD Tumors

Johnson, Felicia

doi:10.1159/000225671

Cited by 23 publications

(12 citation statements)

References 8 publications

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“…Three of our patients were males, including a 9-year-old child. This is in contrast to reports in the literature where most cases have been described in women [14,7,[10][11][12]141. There is only one reported case of hepatic carcinoid in a child [8].…”

Section: Discussioncontrasting

confidence: 91%

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Primary carcinoid tumor of the liver: Report of four resected cases including one with gastrin production

et al. 1996

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Section: Discussioncontrasting

confidence: 91%

“…Since then, to our knowledge 10 more cases have been reported . Only a few of these reported cases have been functioning tumors [2,8,11,12]. Demonstration of the hepatic origin of these tumors may be difficult because the liver is a frequent site for metastasis of carcinoids from the bowel and the pancreas.…”

Section: Introductionmentioning

confidence: 99%

Primary carcinoid tumor of the liver: Report of four resected cases including one with gastrin production

et al. 1996

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“…The liver was not included as the primary site of origin, probably because a primary hepatic neuroendocrine tumor is extremely rare. To date, only 42 cases of neuroendocrine tumor arising primarily from the liver have been reported [1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30]. The important clinical data and morphologic findings of these patients, including the 2 cases reported here, are summarized in table 1.…”

Section: Discussionmentioning

confidence: 99%

“…The most frequent symptom was abdominal mass, whereas only 9 of 44 patients (20.5%) were reported to have symptoms related to the carcinoid syndrome or attributable to the release of specific hormones [1, 5, 8, 9, 10, 14, 15, 18]. …”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Neuroendocrine Tumor: Successful Hepatectomy in Two Cases and Review of the Literature

Rückert¹,

Rückert²,

Dörffel³

et al. 1999

Digestion

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Background/Aims: Primary hepatic neuroendocrine tumor represents an extremely rare clinical entity with only very few cases having been reported to date. Methods: The case histories of 2 patients with presumably primary hepatic neuroendocrine tumor were analyzed and a complete follow-up obtained. The literature was reviewed to provide comprehensive data collection. Results: Both patients underwent partial hepatic resection. Histomorphologic diagnosis revealed a neuroendocrine tumor in both cases. Extensive preoperative as well as intra- and postoperative search for the primary tumor did not identify another site of neuroendocrine tumor tissue. Six and ten years after hepatic segmentectomy, the 2 patients are alive and show no clinical signs of malignancy. Their most recent thorough follow-up included computed tomography and somatostatin receptor scintigraphy. Neither a nonhepatic primary neuroendocrine tumor site nor recurrent disease was found in the 2 patients. The literature review resulted in a complete survey of all previously reported cases of primary hepatic neuroendocrine tumors. Conclusion: We conclude that the liver was the primary site of the neuroendocrine tumor in both patients. Radical surgery was successfully performed as the only treatment option with curative intention.

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“…In our study, the tumour did not belong to any organ in particular, and was located in the mesentery. Other authors have also reported cases of NET associated with ectopic ACTH secretion with infrequent or unusual presentations (Johnson 1982;Otsuka et al 2005;Thomas et al 2013). The most frequent locations for the ACTHsecreting carcinoid are the lungs, pancreas, thyroid and adrenal medulla (Clark and Carney 1987;Terzolo et al 2001;Otzuka et al 2005).…”

Section: Discussionmentioning

confidence: 98%

Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report

Castillo¹,

Pessina²,

García³

et al. 2014

Vet. Med. - Czech

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Ectopic ACTH secretion is provoked by extra-pituitary tumours that secrete ACTH, constituting an infrequent type of Cushing Syndrome in the dog. Neuroendocrine tumours (NET) are characterised by the synthesis of peptides with hormone activity. A dog with clinical diagnosis of Cushing's syndrome and presenting an abdominal tumour located in the area of the left adrenal gland was sent to the hospital. Cortisol was not inhibited at four and eight hours after the application of low-dose dexamethasone and the cortisol/creatinine ratio was elevated (93 × 10 -6 , reference values < 10 × 10 -6 ). Plasma ACTH measurements were high (28.6 pmol/l, reference values 5.5-14.3 pmol/l). On computed tomography, the tumour was found in the meso-epigastrium, with both adrenal glands hyperplasic and no alteration of the pituitary image. The tumour was located between the two layers of the meso-colon and was removed using laparoscopy. After surgery, ACTH concentrations became normal and clinical signs remitted. The histopathological diagnosis was NET, with positive ACTH immunostaining.

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Ectopic ACTH Syndrome in APUD Tumors

Cited by 23 publications

References 8 publications

Primary carcinoid tumor of the liver: Report of four resected cases including one with gastrin production

Primary carcinoid tumor of the liver: Report of four resected cases including one with gastrin production

Primary Hepatic Neuroendocrine Tumor: Successful Hepatectomy in Two Cases and Review of the Literature

Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report

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