Ectomesoderm and epithelial–mesenchymal transition‐related genes in spiralian development

Osborne, C. Cornelia; Perry, Kimberly J.; Shankland, Marty; Henry, Jonathan J.

doi:10.1002/dvdy.24667

Cited by 18 publications

(19 citation statements)

References 142 publications

(253 reference statements)

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“…The slipper snail Crepidula fornicata is perhaps the most high-profile species in the context of the study of molluscan development [37] (alongside Tritia (Ilyanassa) obsoleta , table 1). While the original research on the species was used to create the cell lineage nomenclature of spiral cleavage [101], recent work has produced high-resolution cell lineage fate maps, described the morphogenetic events during gastrulation, and provided important insight into the molecular basis of early development [102–104]. Notably, C. fornicata was also the first molluscan species in which CRISPR/Cas9 genome editing was demonstrated [105].…”

Section: Slipper Shell Crepidula: Early Developmentmentioning

confidence: 99%

Mobilizing molluscan models and genomes in biology

Davison

Neiman

2021

Phil. Trans. R. Soc. B

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Molluscs are among the most ancient, diverse, and important of all animal taxa. Even so, no individual mollusc species has emerged as a broadly applied model system in biology. We here make the case that both perceptual and methodological barriers have played a role in the relative neglect of molluscs as research organisms. We then summarize the current application and potential of molluscs and their genomes to address important questions in animal biology, and the state of the field when it comes to the availability of resources such as genome assemblies, cell lines, and other key elements necessary to mobilising the development of molluscan model systems. We conclude by contending that a cohesive research community that works together to elevate multiple molluscan systems to ‘model’ status will create new opportunities in addressing basic and applied biological problems, including general features of animal evolution. This article is part of the Theo Murphy meeting issue ‘Molluscan genomics: broad insights and future directions for a neglected phylum’.

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Section: Slipper Shell Crepidula: Early Developmentmentioning

confidence: 99%

Mobilizing molluscan models and genomes in biology

Davison

Neiman

2021

Phil. Trans. R. Soc. B

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“…micromeres from the animal pole/anterior end of the blastopore) (summarized by Henry and Martindale, 1999 ; Kozin and Kostyuchenko, 2016 ; Lambert, 2008 ; Lyons and Henry, 2014 ), and in ecdysozoans, where mesoderm originates either from internalization of vegetal endomesodermal cells ( Martin-Duran and Hejnol, 2015 ; Sulston et al, 1983 ) or from cells of the blastoderm ( Eriksson and Tait, 2012 ; Hartenstein et al, 1985 ). Despite the differences in the embryological origin and morphogenesis, the molecular underpinnings of mesoderm induction, migration and differentiation into various derivatives shares similarities within bilaterians ( Amin et al, 2009 , 2010 ; Andrikou et al, 2013 ; Chiodin et al, 2013 ; Fritzenwanker et al, 2014 ; Grifone et al, 2005 ; Harfe et al, 1998 ; Hinman and Degnan, 2002 ; Imai et al, 2004 ; Kozin et al, 2016 ; Kozmik et al, 2007 ; Mahlapuu et al, 2001 ; Mankoo et al, 1999 ; Materna et al, 2013 ; Nederbragt et al, 2002 ; Osborne et al, 2018 ; Passamaneck et al, 2015 ; Perry et al, 2015 ; Rudnicki et al, 1993 ; Sandmann et al, 2007 ; Schubert et al, 2003 ; Shimeld et al, 2010 ; Zaffran et al, 2001 ) ( ). These molecular similarities have been commonly used as an argument for the homology of this germ layer ( Burton, 2008 ; Lartillot et al, 2002 ; Martindale et al, 2004 ; Seipel and Schmid, 2005 ; Technau and Scholz, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

FGF signaling acts on different levels of mesoderm development within Spiralia

Andrikou

Hejnol

2021

Development

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FGF signaling is involved in mesoderm induction in members of deuterostomes (e.g. tunicates, hemichordates), but not in flies and nematodes, in which it has a role in mesoderm patterning and migration. However, we need comparable studies in other protostome taxa in order to decipher whether this mesoderm-inducing function of FGF extends beyond the lineage of deuterostomes. Here, we investigated the role of FGF signaling in mesoderm development in three species of lophophorates, a clade within the protostome group Spiralia. Our gene expression analyses show that the mesodermal molecular patterning is conserved between brachiopods and phoronids, but the spatial and temporal recruitment of transcription factors differs significantly. Moreover, the use of the inhibitor SU5402 demonstrates that FGF signaling is involved in different steps of mesoderm development, as well as in morphogenetic movements of gastrulation and axial elongation. Our findings suggest that the mesoderm-inducing role of FGF extends beyond the group of deuterostomes.

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“…Previous studies focus on the factors that regulate invasion and metastasis in the early stage of cancer development, with the purpose of providing a reliable foundation for early diagnosis and treatment (23-25). The epithelial-mesenchymal transition (EMT) program of tumor cells is closely associated with invasion and migration (26,27). Cells lose polarity during EMT, undergo remodification of the cytoskeleton, alter their original morphology and transform into cells with the capacity to relocate during EMT (28).…”

Section: Introductionmentioning

confidence: 99%

Lysophosphatidic acid induces the migration and invasion of SGC-7901 gastric cancer cells through the LPA2 and Notch signaling pathways

Ren

Zhang

et al. 2019

Int J Mol Med

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Lysophosphatidic acid (LPA), a simple water-soluble glycerophospholipid with growth factor-like activity, regulates certain behaviors of multiple cancer types by binding to its receptor, LPA receptor 2 (LPA2). Notch1 is a key mediator in multiple human cancer cell types. The association between LPA2 and Notch1 in gastric cancer cells is not well known. The present study aimed to investigate the function of LPA2 and Notch1 in controlling the migration and invasion activities of SGC-7901 gastric cancer cells following stimulation with LPA. It was revealed that LPA may stimulate the expression of Notch1 and Hes family bHLH transcription factor 1, and the phosphorylation of protein kinase B which belongs to the Notch pathway. Furthermore, by performing transwell migration and invasion assays, immunofluorescent staining, analyzing the expression of markers for the epithelial-mesenchymal transition (EMT) and downregulating LPA2 and Notch1 expression, it was verified that LPA2 and Notch1 mediated the metastasis, invasion, EMT and rebuilding of the cytoskeleton of SGC-7901 cells upon LPA treatment. An immunoprecipitation assay revealed that LPA2 interacted with Notch1 in SGC-7901 cells. The present study may provide novel ideas and an experimental basis for identifying the factors that affect the functions of SGC-7901 cells.

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Ectomesoderm and epithelial–mesenchymal transition‐related genes in spiralian development

Cited by 18 publications

References 142 publications

Mobilizing molluscan models and genomes in biology

Mobilizing molluscan models and genomes in biology

FGF signaling acts on different levels of mesoderm development within Spiralia

Lysophosphatidic acid induces the migration and invasion of SGC-7901 gastric cancer cells through the LPA2 and Notch signaling pathways

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