Ectomesenchymal Chondromyxoid Tumor: Report of a Case With Description of Histologic and Immunohistochemical Findings

Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report

“…Looking for classical light microscopic features pointing to pleomorphic adenomas, Ide et al, 6 Chopra et al, 14 and Closmann et al 23 were unable to find ductal structures in ECTs. In addition, Argyris et al 29 could not find molecular genetic rearrangement of pleomorphic adenoma gene 1 (PLAG1) in seven cases.…”

“…Of them, 45 were located on the anterior aspect of the tongue and ranged in size from 3 to 50 mm (mean 13.3 mm) 1 – 3 , 5 – 7 , 9 – 24 , 26 , 28 , 30 , 31 ; the two lesions on the posterior tongue each had a diameter of 20 mm. 4 , 16 In the 31 cases (exclusively anterior lesions) that described the impression of palpation, 19 cases were described as firm 1 , 2 , 5 , 7 , 9 , 10 , 12 – 14 , 16 , 17 , 20 , 23 , 26 , 31 , 1 as soft 1 , 1 cystic, 1 1 firm-cystic 1 , 4 elastic, 3 , 18 , 19 , 22 2 non-tender 24 , 28 , 1 tender 20 , 1 firm-cystic 1 , 1 soft-cystic. 6 …”

Ectomesenchymal chondromyxoid tumor with a significant proliferative index: A case report

“…1,2,5,6,8,11,12,18,19 Histologically, the present case meets the morphological criteria for the diagnosis of ECT. 2,[4][5][6]8,11,15,[17][18][19][20][21][22][23] The tumor is characterized by a lobular growth pattern with cystic spaces and stroma with myxoid, chondroid and myxochondroid areas, and by hypercellularity -especially small cells, which seem to predominate in ECT. 5 Another particular feature is neoplastic cells surrounding muscle cells, 5,15,16,24 but this does not seem to represent evidence of an ECT's aggressive behavior.…”

“…The main differential diagnosis of the ECT includes myoepithelioma 2,3,[5][6][7][8]11,12,15,17,19,20,23,24,31,32 and pleomorphic adenoma. 2,3,5,7,8,12,17,20,31 However, despite the presence of chondroid and myxoid differentiation and spindle-shaped cells, we found no plasmacytoid cells, glandular ducts, or salivary gland tissue. Other differential diagnoses are myxoma, mucocele, oral focal mucinosis, neurofibroma, and schwannoma.…”

Nodular lesion in the buccal mucosa

“…ECT was first described in 1995, 1 with 52 cases reported in the English-language literature: 50 cases were in the tongue; 1 was in the hard palate; and 1 was in the buccal mucosa. [1][2][3][4][5][6][7][8] The cases described in the literature reported that ECT most commonly affects adults in the third to sixth decades of life. Clinically, ECT presents as a slow-growing, painless, firm, wellcircumscribed, submucosal nodule, covered by normal mucosa, that appears to involve only the oral cavity and usually is located on the anterior dorsum of the tongue.…”