Ectoine in the treatment of ocular allergy

Mrukwa–Kominek, Ewa; Janiszewska-Salamon, Julia; Luboń, Wojciech

doi:10.5603/oj.2016.0014

Cited by 1 publication

(5 citation statements)

References 6 publications

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“…The 16 studies reviewed can be divided into two main groups: Studies investigating treatment of allergic conjunctivitis with EED [ 33 , 56 , 57 , 59 , 62 , 65 , 68 ] ( Table 1 ) Studies investigating treatment of nonspecific irritation of the eye surface with EED [ 58 , 60 , 61 , 63 , 64 , 66 , 67 , 69 , 70 ] ( Table 2 ) …”

Section: Results From Included Clinical Trialsmentioning

confidence: 99%

“…Studies investigating treatment of allergic conjunctivitis with EED [ 33 , 56 , 57 , 59 , 62 , 65 , 68 ] ( Table 1 )…”

Section: Results From Included Clinical Trialsmentioning

confidence: 99%

“…Within the scope of allergic conjunctivitis, 5 studies investigated the effect of EED in seasonal allergic rhinitis [ 33 , 59 , 62 , 65 , 68 ], and 2 studies included patients with vernal conjunctivitis [ 56 , 57 ]. Primary outcome parameters of all studies were patient-reported symptoms together with study-specific measurements related to the respective study endpoints.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the study medication, an eye drop formulation with 2% ectoine, 0.35% hydroxyethyl cellulose, 0.35% NaCl, citrate buffer, and water was applied in all except one study. This study [ 71 ] used a formulation of 2% ectoine, 0.2% sodium hyaluronate, 0.35% NaCl, and water.…”

Section: Methodsmentioning

confidence: 99%

“…Most of the studies did not comment on randomization (9/16). The number of study arms ranged from single-arm trials ( n = 4) [ 56 , 59 , 62 , 63 , 74 ] over 2 armed trials ( n = 10) to one study with 4 arms [ 70 ]. One study used historic controls [ 61 ].…”

Section: Methodsmentioning

confidence: 99%

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Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface

Bilstein¹,

Heinrich

Rybachuk

et al. 2021

BioMed Research International

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The ocular surface is facing various unspecific stress factors resulting in irritation and inflammation of the epithelia, causing discomfort to the patients. Ectoine is a bacteria-derived extremolyte with the ability to protect proteins and biological membranes from damage caused by extreme environmental conditions like heat, UV-light, high osmolarity, or dryness. Evidence from preclinical and clinical studies attest its effectiveness in treating several epithelium-associated inflammatory diseases, including the eye surface. In this review, we analysed 16 recent clinical trials investigating ectoine eye drops in patients with allergic conjunctivitis or with other unspecific ocular inflammations caused by e.g. ophthalmic surgery. Findings from these studies were reviewed in context with other published work on ectoine. In summary, patients with irritations and unspecific inflammations of the ocular surface have been treated successfully with ectoine-containing eye drops. In these patients, significant improvement was observed in ocular symptoms of allergic rhinoconjunctivitis, postoperative secondary dry eye syndrome, or ocular reepithelisation after surgery. Using ectoine as an add-on therapy to antihistamines, in allergy patients accelerated symptom relief by days, and its use as an add-on to antibiotics resulted in faster wound closure. Ectoine is a natural substance with an excellent tolerability and safety profile thus representing a helpful alternative for patients with inflammatory irritation of the ocular surface, who wish to avoid local reactions and side effects associated with pharmacological therapies or wish to increase the efficacy of standard treatment regimen.

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